Anti-Inflammatory and Anti-Nociceptive Activities of the Ethanolic Extract of Annona muricata Leaf


  • University Putra Malaysia, UPM, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Serdang, Selangor, 43400, Malaysia


Ethanolic extract of Annona muricata leaf (AML) was used to investigate its anti-inflammatory and antinociceptive activities by using carrageenan - induced oedema model and acetic acid induced writhing test. AML exhibited significant and dose-dependent anti-inflammatory activity at a dose of 10, 30, 100 and 300 mg/kg when administered orally. It is also demonstrated that the intraperitoneal administration of AML at a dose of 30, 100 and 300 mg/kg produced significant inhibition of abdominal constriction induced with 0.6% (v/v) acetic acid in dose dependent manner. These results indicate that AML exhibits significant anti-inflammatory and antinociceptive effects.


Annona muricata, Acetic Acid Induced Writhing, Carrageenan-Induced Oedema.

Subject Discipline

Pharmacy and Pharmacology

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