Overview of Effective Traditional Medicinal Plants having Antihyperlipidemic Activity

Authors

  • Sireesha Rayadurgam
  • K. Manikandan

DOI:

https://doi.org/10.18311/jnr/2022/29791

Keywords:

Antihyperlipidemic Activity, Atherosclerosis, Hyperlipidemia, Lipid-lowering Agents, Medicinal Plants

Abstract

Hyperlipidemia is characterized by excessive levels of lipids (cholesterol and triglycerides) in the blood. Elevated plasma concentrations of distinct lipid and lipoprotein fractions are key risk factors for Cardiovascular Disease (CVD). Natural ingredients have long been used to treat and prevent cardiovascular issues. Much research on natural compounds that are effective against hyperlipidemia has been done in recent decades as of interest. PubMed, Science Direct, Google Scholar, and Scopus are the search engines used to collect information. We picked anti-hyperlipidemia, atherosclerosis, and therapeutic plants as search terms. The goal of this article is to offer a rapid summary of herbal treatments used to treat and prevent atherosclerosis based on anti-hyperlipidemic action. This research aimed to analyze the anti-hyperlipidemic effectiveness of medicinal plants that have been scientifically demonstrated to be helpful.

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References

Greaves DR, Gordon S. Immunity, atherosclerosis and cardiovascular disease. Trends Immunol. 2001; 22:180- 1. https://doi.org/10.1016/S1471-4906(00)01848-2.

Phogat P, Deep A, Sharma PC, Mittal SK, Kakkar S, Goyal R, et al. Introduction to hyperlipidemia and its management: a review. Pharmacologyonline. 2010; 2:251-66.

Introduction and importance of medicinal plants and herbs. National Health Portal of India. Available from: https://www.nhp.gov.in/introduction-and-importanceof- medicinal-plants-and-herbs_mtl

Ibrahim SRM, Mohamed GA, Banjar ZM, Kamal HKM. Natural antihyperlipidemic agents: Current status and future perspectives. Phytopharmacology. 2013; 4:492- 531.

Koshy AS, Vijayalakshmi NR. Impact of certain flavonoids on lipid profiles potential action of Garcinia cambogia flavonoids. Phyther Res. 2001; 15:395-400. https://doi.org/10.1002/ptr.725. PMid:11507730

Sawale PD, Pothuraju R, Abdul Hussain S, Kumar A, Kapila S, Patil GR. Hypolipidaemic and anti-oxidative potential of encapsulated herb (Terminalia arjuna) added vanilla chocolate milk in high cholesterol fed rats. J Sci Food Agric. 2016; 96:1380-5. https://doi.org/10.1002/ jsfa.7234. PMid:25907198

Devi VG, John A, Sreekala Devi R, Prabhakaran VA. Pharmacognostical studies on Acacia catechu willd and identification of antioxidant principles. Int J Pharm Pharm Sci. 2011; 3:108-11.

Satpudke S, Pansare T, Khandekar S. Review on Arjuna (Terminalia Arjuna Roxb.) with Special Reference To Prameha (Diabetes ). Int J Herb Med. 2019; 8:1-5.

Sasikala TP, Kamakshamma J. Genetic diversity assessed through RAPD Markers in Terminalia Pallida Brandis. J Pharm Sci Res. 2015; 7:58-62.

Edwin J, Joshi SB, Jain DC. Biochemical study on the hypoglycemic effects of extract and fraction of barks of Cassia fistula Linn. in alloxan-induced diabetic rats. Indian Drugs. 2009; 46:54-60.

Patel AJ, Patel NM, Patel AA, Patel J. Interaction of Trigonella Foenum-Graecum (Fenugreek) and Acacia Catechu (Black Catechu) for Antihyperlipidemic Activity. J Pharm Sci Biosci Res. 2011; 1:54-8.

Ramachandran C, Nair SM, Quirrin KW, Melnick SJ. Hypolipidemic effects of a proprietary Commiphora Mukul gum resin extract and medium-chain triglyceride preparation (GU-MCT810). J Evidence-Based Complement Altern Med. 2013; 18:248-56. https://doi. org/10.1177/2156587213488601.

Ramesh B, Saralakumari D. Antihyperglycemic, hypolipidemic and antioxidant activities of ethanolic extract of Commiphora mukul gum resin in fructose-fed male Wistar rats. J Physiol Biochem. 2012; 68:573-82. https:// doi.org/10.1007/s13105-012-0175-x. PMid:22581434

Bellamkonda R, Karuna R, Rao BSB, Haritha K, Manjunatha B, Silpa S, et al. Beneficiary effect of Commiphora mukul ethanolic extract against high fructose diet induced abnormalities in carbohydrate and lipid metabolism in wistar rats. J Tradit Complement Med. 2018; 8:203-11. https://doi. org/10.1016/j.jtcme.2017.05.007. PMid:29322010. PMCid:PMC5755988

Shaik J, Khan Z. Antihyperlipidemic activity of Commiphora mukul against atherogenic diet-induced hyperlipidemia in experimental rats. Asian J Pharm Clin Res. 2018; 11:386-9. https://doi.org/10.22159/ajpcr.2018. v11i6.24800.

Anas M, Rahman Z, Ahmad T. Antihyperlipidemic activity of Commiphora mukul: A review. Pharma Innov J. 2019; 8:496-8.

Siddiqui MZ, Mazumder PM. Comparative study of hypolipidemic profile of resinoids of Commiphora mukul/Commiphora wightii from different geographical locations. Indian J Pharm Sci. 2012; 74:422-7. https://doi.org/10.4103/0250-474X.108417. PMid:23716870. PMCid:PMC3660868

Prasad J, Netam AK, Satapathy T, Rao SP, Jain P. Anti-hyperlipidemic and antioxidant activities of a combination of Terminalia arjuna and Commiphora mukul on experimental animals. Lect Notes Bioeng. 2021:175- 88. https://doi.org/10.1007/978-981-15-6329-4_16.

Urizar NL, Moore DD. Gugulipid: A natural cholesterol- lowering agent. Annu Rev Nutr. 2003; 23:303-13. https:// doi.org/10.1146/annurev.nutr.23.011702.073102. PMid:12626688

Jash R, Bagchi C, Mitra A, Tripathi S. Evaluation of antihyperlipidemic activity of gugulipid alone and in combination with different dosage of atorvastatin in triton-induced hyperlipidemic rodent model: Exploring a possible synergistic activity. Natl J Physiol Pharm Pharmacol. 2021:1. https://doi.org/10.5455/njppp.2022. 12.08304202101092021.

Ahmad MA, Mujeeb M, Akhtar M, Khushtar M, Arif M, Haque MR. Guggulipid: A promising multipurpose herbal medicinal agent. Drug Res (Stuttg). 2020; 70:123-30. https://doi.org/10.1055/a-1115-4669. PMid:32110820

Shaik J, Khan Z. Antihyperlipidemic activity of Commiphora mukul against atherogenic diet-induced hyperlipidemia in experimental rats. Asian J Pharm Clin Res. 2018; 11:386-9. https://doi.org/10.22159/ajpcr.2018. v11i6.24800

Sotoudeh R, Hadjzadeh M-A-R, Gholamnezhad Z, Aghaei A. The anti-diabetic and antioxidant effects of a combination of Commiphora mukul, Commiphora myrrha and Terminalia chebula in diabetic rats. Avicenna J Phytomedicine. 2019; 9:454-64.

Espirito Santo BLS do, Santana LF, Kato Junior WH, de Araújo F de O, Bogo D, Freitas K de C, et al. Medicinal potential of Garcinia Species and their compounds. Molecules. 2020; 25:1-30. https://doi.org/10.3390/molecules25194513. PMid:33019745. PMCid:PMC7582350

Fallis A. Estimation of (-)-Hydroxycitric Acid (HCA) In Garcinia Lanceaefolia Roxb. Using Novel HPLC Methodology. J Chem Inf Model. 2013; 53:1689-99. https://doi.org/10.13040/IJPSR.0975-8232.5(11).4993- 97.

Sripradha R, Sridhar MG, Maithilikarpagaselvi N. Antihyperlipidemic and antioxidant activities of the ethanolic extract of Garcinia cambogia on high fat diet-fed rats. J Complement Integr Med. 2016; 13:9-16. https://doi.org/10.1515/jcim-2015-0020.

Mahendran P, Devi CSS. Effect of Garcinia Cambogia extract on lipids and lipoprotein composition in dexamthesone administered rats. Indian J Physiol Pharmacol. 2001; 45:345-50.

Koshy AS, Anila L, Vijayalakshmi NR. Flavonoids from Garcinia cambogia lower lipid levels in hypercholesterolemic rats. Food Chem. 2001; 72:289-94. https://doi. org/10.1016/S0308-8146(00)00225-9.

Rani DJ, Vijayanchali SS. Phytochemical Composition and antioxidant activity of fresh and dried grape (Vitis vinifera) fruit proportions. Int J Innov Sci Res Technol. 2021; 6:734-9.

Baranitharan M, Alarifi S, Alkahtani S, Ali D, Elumalai K, Pandiyan J, et al. Phytochemical analysis and fabrication of silver nanoparticles using Acacia catechu: An efficacious and ecofriendly control tool against selected polyphagous insect pests. Saudi J Biol Sci. 2021; 28:148-56. https://doi.org/10.1016/j.sjbs.2020.09.024. PMid:33424291. PMCid:PMC7785431

Gris EF, Mattivi F, Ferreira EA, Vrhovsek U, Filho DW, Pedrosa RC, et al. Stilbenes and tyrosol as target compounds in the assessment of antioxidant and hypolipidemic activity of Vitis vinifera red wines from Southern Brazil. J Agric Food Chem. 2011; 59:7954-61. https://doi.org/10.1021/jf2008056. PMid:21718033

Tiwari P, Patel RK. Evaluation of diuretic potential of draksharishta prepared by traditional and modern methods in experimental rats. Pharmacologyonline. 2011; 3:566-72.

Devi S, Singh R. Evaluation of antioxidant and antihypercholesterolemic potential of Vitis vinifera leaves. Food Sci Hum Wellness. 2017; 6:131-6. https://doi. org/10.1016/j.fshw.2017.07.002.

Ngamukote S, Mäkynen K, Thilawech T, Adisakwattana S. Cholesterol-lowering activity of the major polyphenols in grape seed. Molecules. 2011; 16:5054-61. https:// doi.org/10.3390/molecules16065054. PMid:21694670. PMCid:PMC6264176

Ahmed M, Hegde SV, Chavan A. Evaluation of hepatoprotective activity of Vitis vinifera stem bark. J Pharm Res. 2012; 5:5228-30.

Al-Jumaily EF, Shafiq ZA, Al-Bayati RI. Antihyperglycemia effects of resvertrol and its derivative on alloxan diabetic rabbits. IOSR J Pharm. 2012; 2:49-57. https://doi.org/10.9790/3013-24104957.

Verma A, Kumar B, Alam P, Singh V, Kumar Gupta S. Rubia Cordifolia-a Review on Pharmaconosy and Phytochemistry. Int J Pharm Sci Res. 2016; 7:2720. https://doi.org/10.13040/IJPSR.0975-8232.7(7).2720-31.

Priya MD, Siril EA. Traditional and modern use of Indian Madder (Rubia cordifolia L.): An overview. Int J Pharm Sci Rev Res. 2014; 25:154-64.

Baskar R, Bhakshu LM, Bharathi GV, Reddy SS, Karuna R, Reddy GK, et al. Antihyperglycemic activity of aqueous root extract of Rubia cordifolia in streptozotohttps cin-induced diabetic rats. Pharm Biol. 2006; 44:475-9. https://doi.org/10.1080/13880200600798593.

Khan MS, Aziz S, Khan MZ, Khalid ZM, Riaz M, Ahmed D, et al. Antihyperglycemic effect and phytochemical investigation of Rubia cordifolia (Indian Madder) leaves extract. Open Chem. 2021; 19:586-99. https://doi. org/10.1515/chem-2021-0053.

Dwivedi S, Chopra D. Revisiting Terminalia arjunaan ancient cardiovascular drug. J Tradit Complement Med. 2014; 4:224-31. https://doi.org/10.4103/2225- 4110.139103. PMid:25379463. PMCid:PMC4220499

Maulik SK, Talwar KK. Therapeutic potential of Terminalia arjuna in cardiovascular disorders. Am J Cardiovasc Drugs. 2012; 12:157-63. https://doi.org/10.2165/11598990-000000000-00000. PMid:22583146

Subramaniam S, Subramaniam R, Rajapandian S, Uthrapathi S, Gnanamanickam VR, Dubey GP. Antiatherogenic activity of ethanolic fraction of Terminalia arjuna bark on hypercholesterolemic rabbits. Evidence- Based Complement Altern Med. 2011b; 2011. https:// doi.org/10.1093/ecam/neq003. PMid:21785628. PMCid:PMC3136348

Ansarullah, Jadeja R, Thounaojam M, Patel V, Devkar R, Ramachandran A. Antihyperlipidemic potential of a polyherbal preparation on Triton WR 1339 (Tyloxapol) induced hyperlipidemia: A comparison with lovastatin. Int J Green Pharm. 2009; 3:119-24. https://doi. org/10.4103/0973-8258.54900.

Uthirapathy S. Novel biomarkers of atherogenic diet induced dyslipidemia and metabolic syndrome suppressed By Terminalia arjuna. Int J Pharm Sci Res. 2019; 10:2528-36. https://doi.org/10.13040/IJPSR.0975- 8232.10(5).2528-36.

Patil RH, Prakash K, Maheshwari VL. Hypolipidemic effect of Terminalia arjuna (L.) In experimentally induced hypercholesteremic rats. Acta Biol Szeged. 2011; 55:289-93.

Sawale PD, Pothuraju R, Abdul Hussain S, Kumar A, Kapila S, Patil GR. Hypolipidaemic and anti-oxidative potential of encapsulated herb (Terminalia arjuna) added vanilla chocolate milk in high cholesterol fed rats. J Sci Food Agric. 2016; 96:1380-5. https://doi.org/10.1002/ jsfa.7234. PMid:25907198

Subramaniam S, Ramachandran S, Uthrapathi S, Gnamanickam VR, Dubey GP. Anti-hyperlipidemic and antioxidant potential of different fractions of Terminalia arjuna Roxb. bark against PX-407 induced hyperlipidemia. Indian J Exp Biol. 2011a; 49:282-8. PMid:21785628. PMCid:PMC3136348

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Published

2022-07-30

How to Cite

Rayadurgam, S., & Manikandan, K. (2022). Overview of Effective Traditional Medicinal Plants having Antihyperlipidemic Activity. Journal of Natural Remedies, 22(3), 310–317. https://doi.org/10.18311/jnr/2022/29791

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Short Review