Antihyperglycemic and Hypoglycemic Effect of Ficus racemosa Leaves
Objective: To investigate the hypoglycemic and antihyperglycemic effects of an ethanolic extract of the leaves of Ficus racemosa in both normal and alloxan induced diabetes in rats. Materials and Methods: Blood samples were collected from the retro-orbital plexus under light ether anesthesia before and at 0.5, 1, 2, 4, 6, 8 and 12 h after the oral administration of 100, 200, and 300 /kg doses. Blood glucose was analyzed by glucose-oxidase method using a visible spectrophotometer. Results: Graded doses of the alcoholic extract when given to both normal and diabetic rats produce significant reductions in blood glucose at the 6 h after ethanolic extract administration (P < 0.001). The effect was found to be dose dependent with all treatments at the doses administered. Conclusion: The present study clearly indicated a significant antidiabetic activity of the leaves of Ficus racemosa and supports the traditional usage of fruits by the Ayurvedic physicians for the control of diabetes.
Ficus racemosa, Blood Glucose, Alloxan, Diabetes Mellitus, Rats.
Pharmacy and Pharmacology
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