TY - JOUR AU - Sharma, Paras AU - Hullatti, K. K. AU - Kuppasth, I. J. AU - Sharma, Sakshy PY - 2010/01/01 Y2 - 2024/03/29 TI - Studies on Anti-Asthmatic Property of Cyamopsis tetragonoloba (L.) Taub. Leaf Extracts JF - Journal of Natural Remedies JA - JNR VL - 10 IS - 1 SE - Articles DO - 10.18311/jnr/2010/430 UR - https://informaticsjournals.com/index.php/jnr/article/view/430 SP - 81-86 AB - Objectives: The present study has been designed to evaluate the anti-asthmatic activity of leaves of <em>Cyamopsis tetragonoloba</em> on in-vitro and in-vivo models. Material and methods: The anti-asthmatic activity was carried out on isolated guinea pig ileum preparation (in-vitro), histamine induced bronchospasm in guinea pigs and milk-induced leukocytosis and eosinophilia in mice. Results: Results showed that, the aqueous extract of the leaves significantly inhibited (p&lt;0.05) the contractile effect of histamine. Both Aqueous and alcoholic extracts were found to inhibit (p&lt;0.001 and p&lt;0.05) bronchospasm induced by histamine in guinea pigs by varying degree. Treatment with aqueous as well as alcoholic extracts of the plant decrease blood eosinophilia and leukocyte count by 80% and 90% respectively. Conclusion: The leaves of the plant showed significant anti-histaminic effect in both <em>in-vitro</em> and <em>in-vivo</em> models and adaptogenic activity, thus can be consider being use full in treatment of asthma. ER -