Treatment Outcome with A Revascularization Protocol Using Double and Triple Antibiotic Pastes in Immature Necrotic Teeth – A Double Blinded Randomized Control Clinical Trial
Keywords:Double antibiotic paste Regenerative endodontics Revasculasrisation protocol Triple antibiotic paste
Aim: The aim of this clinical trial is to evaluate the regenerative potential of two antibiotic pastes in permanent teeth with necrotic pulp and open apex and compare it with a standard treatment using mineral trioxide aggregate.
Materials and methods: This interventional study was conducted to assess the revascularization potential. It was designed with two test arms and one control arm. LA was administered, access was established under rubber dam, irrigation was done, and each tooth received an antibiotic paste depending on the test arm to which it belonged. The control arm received a standard MTA apexification. Primary and secondary outcomes were assessed at baseline, 6 months and 12 months. Data were tabulated and analyzed.
Results: Though there was an increase in root length in the test arms, the difference was not statistically significant among the various groups at the different time intervals of assessment. Overall, the mean pain scores decreased over the study period in all the three groups. Though no root closure was found at baseline among the test groups, a statistically significant improvement in the root closure scores was observed in Group A, when compared to Group B, at the end of 6th and 12th month of intervention.
Conclusion: The results to this study show that the revascularization potential of triple antibiotic paste is superior to that of the double antibiotic group. The increase in the root length is statistically superior over the study period in the triple antibiotic arm when compared to that of the double antibiotic arm.
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