Role of Synbiotics in Improvement of Feed Tolerance and Weight Gain in the Newborns

Jump To References Section

Authors

  • ,IN
  • ,IN
  • ,IN
  • ,IN
  • ,IN

Keywords:

Newborns, Probiotics, Prebiotics, Synbiotics, Feed Tolerance, Weight Gain
Education and Research

Abstract

Objective: To study the effect of Synbiotics on weight gain and feed tolerance of newborns.

Methods: This prospective interventional trial included 50 newborns treated with a dietary supplement containing Synbiotics in addition to the routine treatment and 48 newborns served as control without Synbiotics supplement. The primary outcome was weight gain and feed tolerance. Results: Newborns in the Synbiotics group reached the full feeds earlier as compared to those in Control group (7.5 ± 4.26 days Vs 14.02 ± 7.88 days p=0.532) along with better weight gain(14.61 ± 9.6 grams per day Vs 2.97 ± 3.81 grams per day p=0.0000001).

Conclusions: Newborns receiving Synbiotics are more likely to reach full feeds earlier and show better weight gain.

Downloads

Published

2014-07-01

Issue

Section

Original Research Article

 

References

Allen SJ, Okoko B, Martinez E, Gregorio G, Dans LF. Probiotics for treating infectious diarrhoea. Cochrane Database Syst Rev. 2004; 2:1–71.

Kolars JC, Levitt MD, Aouji M, Savaiano DA. Yogurt”an autodigesting source of lactose. N Engl J Med. 1984; 310: 1–3.

de Vrese M, Stegelmann A, Richter B, Fenselau S, Laue C, Schrezenmeir J. Probiotics-compensation for lactase insufficiency. Am J Clin Nutr. 2001; 73(suppl):421S–29S.

Van Niel CW. Probiotics: not just for treatment anymore. Pediatrics. 2005; 115:174–77.

Bell EF. Preventing necrotizing enterocolitis: what works and how safe? Pediatrics. 2005; 115:173–74.

Kliegman RM, Willoughby RE. Prevention of necrotizing enterocolitis with probiotics. Pediatrics. 2005; 115: 171–72.

Adams MR, Marteau P. On the safety of lactic acid bacteria. Int J Fd Microbiol. 1995; 27: 263–64.

Naidu AS, Biblack WR, Clemens RA. Probiotic spectra of Lactic Acid Bacteria (LAB). Crit Rev Fd Sci Nutr. 1999; 39:113–26.

Dani C, Biadaioli R, Bertini G, Martelli E, Rubaltelli FF. Probiotics feeding in prevention of urinary tract infection, bacterial sepsis and necrotizing enterocolitis in preterm infants: a prospective doubleblind study. Biol Neonate. 2002; 82(2):103–8.

Kitajima H, Sumida Y, Tanaka R, Yuki N, Takayama H, Fujimura M. Early administration of Bifidobacterium breve to preterm infants: randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. 1997; 76(2):F101–7.

Hoyos AB. Reduced incidence of necrotizing enterocolitis associated with enteral administration of Lactobacillus acidophilus and Bifidobacterium infantis to neonates in an intensive care unit. Int J Infect Dis. 1999; 3:197–2

Costalos C, Skouteri V, Gounaris A, et al. Enteral feeding of premature infants with Saccharomyces boulardii. Early Hum Dev. 2003; 74(2):89–96.

Bin-Nun A, Bromiker R, Wilschanski M, et al. Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates. J Pediatr. 2005; 147(2):192–6.

Mohan R, Koebnick C, Schildt J, et al. Effects of Bifidobacterium lactis Bb12 supplementation on intestinal microbiota of preterm neonates: a double placebo controlled, randomised study. J Clin Microbiol. 2006; 44(11):4025–31.

Lin HC, Su BH, Chen AC, et al. Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants. Pediatrics. 2005; 115(1):1–4

Manzoni P, Mostert M, Leonessa ML, et al. Oral supplementation with Lactobacillus casei subspecies rhamnosus prevents enteric colonization by Candida species in preterm neonates: a randomized study. Clin Infect Dis. 2006; 42(12):1735–42.

Lin HC, Hsu CH, Chen HL, et al. Oral probiotics prevent necrotizing enterocolitis in very low birth weight preterm infants: a multicenter, randomized, controlled trial. Pediatrics 2008; 122(4):693–700.

Stratiki Z, Costalos C, Sevastiadou S, et al. The effect of a Bifidobacter supplemented bovine milk on intestinal permeability of preterm infants. Early Hum Dev. 2007; 83(9):575–9.

Samanta M, Sarkar M, Ghosh P, et al. Prophylactic probiotics for prevention of necrotizing enterocolitis in very low birth weight newborns. J Trop Pediatr. 2009; 55(2):128–31.

Rouge C, Piloquet H, Butel MJ, et al. Oral supplementation with probiotics in verylow-birth-weight preterm infants: a randomized, double-blind, placebo-controlled trial. Am J Clin Nutr. 2009; 89(6):1828–35.

Kukkonen K, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R, Poussa T, Tuure T, Kuitunen M. Long-term safety and impact on infection rates of postnatal probiotic and prebiotic (synbiotic) treatment: randomized, double-blind, placebo-controlled trial. Pediatrics. 2008 Jul; 122(1):8–12.

Indrio F, Riezzo G, Raimondi F, Francavilla R, Montagna O, Valenzano ML, Cavallo L, Boehm G. Prebiotics Improve gastric motility and gastric electrical activity in preterm newborns. J Pediatr Gastroenterol Nutr. 2009; 49:258–61.

Underwood MA, Salzman NH, Bennett SH, Barman M, Mills D, Marcobal A, Tancredi DJ, Bevins CL, Sherman MP. A randomized placebo-controlled comparison of two prebiotic/ probiotic combinations in preterm infants: impact on weight gain, intestinal microbiota, and fecal short chain fatty acids. J Pediatr Gastroenterol Nutr. 2009 Feb; 48(2): 216–25.

Puccio G, Cajozzo C, Meli F, et al. Clinical evaluation of a new starter formula for infants containing live Bifidobacterium longum BL999 and prebiotics. Nutrition. 2007; 23:1–8. [PubMed: 17189085].

Mihatsch WA, Hoegel J, Pohlandt F. Prebiotic oligosaccharides reduce stool viscosity and accelerate gastrointestinal transport in preterm infants. Acta Paediatr 2006; 95(7):843–48.