TY - JOUR AU - Nithyashree, N. AU - Prakash, N AU - Waghe, Prashantkumar AU - Santhosh, C. R. AU - Pavithra, B. H. AU - Rajashekaraiah, Rashmi AU - Sathyanarayana, M. L. AU - Sunilchandra, U. AU - Anjan Kumar, K. R. AU - Manjunatha, S. S. AU - Muralidhar, Y. AU - Shivaprasad, G. R. PY - 2022/12/12 Y2 - 2024/03/29 TI - Nanocurcumin Restores Arsenic-Induced Disturbances in Neuropharmacological Activities in Wistar Rats JF - Toxicology International JA - TI VL - 29 IS - 3 SE - Research Articles DO - 10.18311/ti/2022/v29i3/30342 UR - https://informaticsjournals.com/index.php/toxi/article/view/30342 SP - 429-445 AB - <p>The present study was carried out to examine the ameliorative potential of nanocurcumin against arsenic induced (sub-chronic) alterations in central nervous system in male Wistar rats. Nanocurcumin was synthesised and the hydrodynamic diameter, zeta potential and particle size were~76.60 nm, (-) 30 mV and 95nm, respectively. Experimental rats sub-chronically exposed to sodium (meta) arsenite (As; 10 mg.kg<sup>-1</sup>; 70 days; p.o) induced significant (<em>p</em>&lt;0.05) reduction in superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione and favoured free radical generation and induced lipid peroxidation in brain tissue. The exposure resulted in significant (p&lt;0.05) decrease in voluntary- and involuntary motor activities and enhanced anxiety levels. However, experimental rats receiving nanocurcumin (15 mg.kg<sup>-1</sup>; p.o) showed significant (<em>p</em>&lt;0.05) recovery in enzymatic - and non-enzymatic antioxidant defence system and restoration of redox balance and overcome arsenic induced depression in motor activities and elevated anxiety levels. Further, Arsenic induced elevation in pro-inflammatory cytokines, cyclooxygenase-2 activity and prostaglandin-E<sub>2</sub> in brain and angiotensin-II levels (plasma) was significantly (<em>p</em>&lt;0.05) ameliorated by nanocurcumin. Additionally, quantitative real -time polymerase chain reaction revealed a fivefold decrease in <em>Nox</em><sub>2</sub> expression in brain following nanocurcumin administration. Thus, the study concludes that nanocurcumin can serve as a potential therapeutic candidate to counter arsenic induced redox imbalance and neuropharmacological disturbances and there exists a vast scope to exploit its utility after appropriate clinical modelling.</p> ER -