Anti-Diabetic Activity of a Polyherbal Formulation in Streptozotocin Induced Type 2 Diabetic Rats


Affiliations

  • Institute of Pharmacy, Nirma University, Ahmedabad, Gujarat, 382481, India
  • Atmiya Institute of Pharmacy, Rajkot, Gujarat, 360005, India
  • K. Patel Phytoextractions Pvt Ltd, Mumbai, Maharashtra, 400092, India

Abstract

The aim of the present study was to determine the anti-diabetic activity of a polyherbal formulation in streptozotocin induced type 2 diabetic rats. The hydroalcoholic extracts of Eugenia jambolana, Gymnema sylvestre, Momordica charantia and Andrographis paniculata and sodhana processed extract of Myristica fragrans were prepared. The 2 day old neonatal rats were injected with 90 mg/kg of streptozotocin intraperitoneally to induce type 2 diabetes. After six weeks of streptozotocin injection, polyherbal formulation was daily administered at a dose of 400 mg/kg body weight to diabetic rats for a period of 28 days. Blood samples were collected from the retro orbital plexus of the eye and blood glucose level was estimated by glucose oxidase-peroxidase method. The study indicated that polyherbal formulation at a dose of 400 mg/kg body weight showed significant decline (p<0.001) in blood glucose level.

Keywords

OGTT, Polyherbal Formulation, Streptozotocin, Type 2 Diabetes

Subject Discipline

Pharmaceutical Sciences

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References

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