Anti-Diabetic Activity of a Polyherbal Formulation in Streptozotocin Induced Type 2 Diabetic Rats

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Authors

  • Tripathi Nagja
     Institute of Pharmacy, Nirma University, Ahmedabad - 382481, Gujarat ,IN
  • Vimal Kumar
     Atmiya Institute of Pharmacy, Rajkot - 360005, Gujarat ,IN
  • Acharya Sanjeev
     K. Patel Phytoextractions Pvt Ltd, Mumbai - 400092, Maharashtra ,IN

DOI:

https://doi.org/10.18311/jnr/2016/15323

Keywords:

OGTT, Polyherbal Formulation, Streptozotocin, Type 2 Diabetes
Pharmacognosy

Abstract

The aim of the present study was to determine the anti-diabetic activity of a polyherbal formulation in streptozotocin induced type 2 diabetic rats. The hydroalcoholic extracts of Eugenia jambolana, Gymnema sylvestre, Momordica charantia and Andrographis paniculata and sodhana processed extract of Myristica fragrans were prepared. The 2 day old neonatal rats were injected with 90 mg/kg of streptozotocin intraperitoneally to induce type 2 diabetes. After six weeks of streptozotocin injection, polyherbal formulation was daily administered at a dose of 400 mg/kg body weight to diabetic rats for a period of 28 days. Blood samples were collected from the retro orbital plexus of the eye and blood glucose level was estimated by glucose oxidase-peroxidase method. The study indicated that polyherbal formulation at a dose of 400 mg/kg body weight showed significant decline (p<0.001) in blood glucose level.

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Published

2017-04-07

How to Cite

Nagja, T., Kumar, V., & Sanjeev, A. (2017). Anti-Diabetic Activity of a Polyherbal Formulation in Streptozotocin Induced Type 2 Diabetic Rats. Journal of Natural Remedies, 16(4), 148–152. https://doi.org/10.18311/jnr/2016/15323

Issue

Volume 16, Issue 4, October 2016

Section

Articles
Crossref
Scopus
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Europe PMC
Received 2017-02-07
Accepted 2017-02-15
Published 2017-04-07

 

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