The Efficacy of Ginger for Pregnancy-Induced Nausea and Vomiting: A Systematic Review


Affiliations

  • Higher Colleges of Technology, Health Sciences -Pharmacy Division, Dubai, United Arab Emirates
  • Higher Colleges of Technology, Health Sciences - Pharmacy Division, Dubai, United Arab Emirates

Abstract

Nausea and Vomiting (N/V) are unpalatable manifestations seen commonly during pregnancy, which impinge upon the overall well-being, the productivity and might result in hospitalization. There is growing evidence concerning the efficacy of ginger in alleviating Nausea and Vomiting in Pregnancy (NVP). Therefore, we sought to conduct a systematic review to explore the effectiveness of ginger for NVP. A comprehensive search was conducted in Google Scholar, PubMed, and Science Direct which resulted in identifying five studies. These studies showed that ginger can improve NVP in a statistically significant manner (P< 0.05). Assessing the safety profile of this agent was difficult due to the short duration of intervention, and inconsistency in the dose and dosage form of ginger used. This study helped to glean evidence about the efficacy of ginger in NVP. It also emphasized the need for conducting more studies with a better quality and that are using standardized dose and dosage forms to be able to conduct a meta-analysis.

Keywords

Ginger, Zingiber Officinale, NVP

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References

Mazzotta P, Stewart D, Atanackovic G, et al. Psychosocial morbidity among women with nausea and vomiting of pregnancy: prevalence and association with antiemetic therapy. J Psychosom Obstet Gynaecol. 2000;21:129–36. https://doi.org/10.3109/01674820009075620 PMid:11076334

Chou F-H, Lin L-L, Cooney AT, et al. Psychosocial factors related to nausea, vomiting, and fatigue in early pregnancy.J Nurs Scholarsh Off Publ Sigma Theta Tau Int Honor Soc Nurs Sigma Theta Tau. 2003; 35:119–25. https://doi.org/10.1111/j.1547-5069.2003.00119.x

Swallow BL, Lindow SW, Masson EA, et al. Psychological health in early pregnancy: relationship with nausea and vomiting. J Obstet Gynaecol J Inst Obstet Gynaecol. 2004; 24:28–32. https://doi.org/10.1080/01443610310001620251 PMid:14675977

Madjunkova S, Maltepe C, Koren G, et al. The leading concerns of American women with Nausea and Vomiting of Pregnancy calling motherisk NVP helpline. Obstet Gynecol Int. 2013; 2013: e752980.

Ebrahimi N, Maltepe C, Einarson A. Optimal management of nausea and vomiting of pregnancy. Int J Womens Health. 2010; 2:241–8. https://doi.org/10.2147/IJWH.S6794 PMid:21151729 PMCid:PMC2990891

Einarson A, Maltepe C, Boskovic R, et al. Treatment of nausea and vomiting in pregnancy. Can Fam Physician. 2007; 53:2109–111. PMid:18077743 PMCid:PMC2231543 7. Arsenault M-Y, Lane CA, Mac Kinnon CJ, et al. The management of nausea and vomiting of pregnancy. J Obstet Gynaecol Can JOGC. 2002; 24: 817–31. https://doi.org/10.1016/S1701-2163(16)30475-3

Ding M, Leach M, Bradley H. The effectiveness and safety of ginger for pregnancy-induced nausea and vomiting: a systematic review. Women Birth J Aust Coll Midwives. 2013; 26:e26–30. https://doi.org/10.1016/j.wombi.2012.08.001 PMid:22951628

Viljoen E, Visser J, Koen N, et al. A systematic review and meta-analysis of the effect and safety of ginger in the treatment of pregnancy-associated nausea and vomiting.Nutr J. 2014; 13:20. https://doi.org/10.1186/1475-289113-20 PMid:24642205 PMCid:PMC3995184

Borrelli F, Capasso R, Aviello G, et al. Effectiveness and safety of ginger in the treatment of pregnancy-induced nausea and vomiting. Obstet Gynecol. 2005; 105:849–56.https://doi.org/10.1097/01.AOG.0000154890.47642.23 PMid:15802416

Matsui D, Matsui D. Adherence with Drug Therapy in Pregnancy. Obstet Gynecol Int. 2011; 2012: e796590.

John LJ, Shantakumari N. Herbal medicines use during pregnancy: A review from the Middle East. Oman Med J. 2015; 30:229–36. https://doi.org/10.5001/omj.2015.48 PMid:26366255 PMCid:PMC4561638

Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. Ann Intern Med. 2009; 151:264–9. https://doi.org/10.7326/0003-4819-151-4-20090818000135 PMid:19622511

Jadad AR, Moore RA, Carroll D, et al. Assessing the quality of reports of randomized clinical trials: Is blinding necessary? Control Clin Trials. 1996; 17:1–12. https://doi.org/10.1016/0197-2456(95)00134-4

Oxford Quality Scoring System. Available from: http:// www.pmidcalc.org/?sid=8721797&newtest=Y#

Chittumma P, Kaewkiattikun K, Wiriyasiriwach B.Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: A randomized double-blind controlled trial. J Med Assoc Thail Chotmaihet Thangphaet. 2007; 90:15–20.

Ensiyeh J, Sakineh M-AC. Comparing ginger and vitamin B6 for the treatment of nausea and vomiting in pregnancy: A randomised controlled trial. Midwifery. 2009; 25:649–53. https://doi.org/10.1016/j.midw.2007.10.013 PMid:18272271

Biswas S, Dey R, Kamliya G, et al. A single-masked, randomized, controlled trial of ginger extract in the treatment of nausea and vomiting of pregnancy. JIMSA 2011; 24:167–9.

Saberi F, Sadat Z, Abedzadeh-Kalahroudi M, et al. Acupressure and ginger to relieve nausea and vomiting in pregnancy: A randomized study. Iran Red Crescent Med J. 2013; 15:854–61. https://doi.org/10.5812/ircmj.12984 PMid:24616799 PMCid:PMC3929824

Saberi F, Sadat Z, Abedzadeh-Kalahroudi M, et al. Effect of ginger on relieving nausea and vomiting in pregnancy: A randomized, placebo-controlled trial. Nurs Midwifery Stud. Available from: http://www.ncbi.nlm.nih.gov/pmc/ articles/PMC4228518/

Ernst E, Pittler MH. Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials. Br J Anaesth. 2000; 84:367–71. https://doi.org/10.1093/ oxfordjournals.bja.a013442 PMid:10793599

Chaiyakunapruk N, Kitikannakorn N, Nathisuwan S, et al.The efficacy of ginger for the prevention of postoperative nausea and vomiting: A meta-analysis. Am J Obstet Gynecol. 2006; 194:95–9. https://doi.org/10.1016/j.ajog.2005.06.046 PMid:16389016

Bone ME, Wilkinson DJ, Young JR, et al. Ginger root- A new antiemetic. The effect of ginger root on postoperative nausea and vomiting after major gynaecological surgery. Anaesthesia. 1990; 45:669–71. https://doi.org/10.1111/j.1365-2044.1990.tb14395.x PMid:2205121

Wu K-L, Rayner CK, Chuah S-K, et al. Effects of ginger on gastric emptying and motility in healthy humans. Eur J Gastroenterol Hepatol. 2008; 20:436–40. https://doi.org/10.1097/MEG.0b013e3282f4b224 PMid:18403946

Abdel-Aziz H, Nahrstedt A, Petereit F, et al. 5-HT3 receptor blocking activity of arylalkanes isolated from the rhizome of Zingiber officinale. Planta Med. 2005; 71:609–16.https://doi.org/10.1055/s-2005-871265 PMid:16041645

Abdel-Aziz H, Windeck T, Ploch M, et al. Mode of action of gingerols and shogaols on 5-HT3 receptors: Binding studies, cation uptake by the receptor channel and contraction of isolated guinea-pig ileum. Eur J Pharmacol. 2006; 530:136–43. https://doi.org/10.1016/j.ejphar.2005.10.049 PMid:16364290

Chrubasik S, Pittler MH, Roufogalis BD. Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles. Phytomedicine Int J Phytother Phytopharm. 2005; 12:684–701. https://doi.org/10.1016/j.phymed.2004.07.009 PMid:16194058

Lien H-C, Sun WM, Chen Y-H, et al. Effects of ginger on motion sickness and gastric slow-wave dysrhythmias induced by circular vection. Am J Physiol Gastrointest Liver Physiol. 2003; 284:G481–9. https://doi.org/10.1152/ ajpgi.00164.2002 PMid:12576305

Pertz HH, Lehmann J, Roth-Ehrang R, et al. Effects of ginger constituents on the gastrointestinal tract: role of cholinergic M3 and serotonergic 5-HT3 and 5-HT4 receptors. Planta Med. 2011; 77:973–8. https://doi.org/10.1055/s-0030-1270747 PMid:21305447

Tiran D. Ginger to reduce nausea and vomiting during pregnancy: Evidence of effectiveness is not the same as proof of safety. Complement Ther Clin Pract. 2012; 18:22–5. https://doi.org/10.1016/j.ctcp.2011.08.007 PMid:22196569

Pongrojpaw D, Somprasit C, Chanthasenanont A. A randomized comparison of ginger and dimenhydrinate in the treatment of nausea and vomiting in pregnancy. J Med Assoc Thail Chotmaihet Thangphaet. 2007; 90:1703–9.

Riyazi A, Hensel A, Bauer K, et al. The effect of the volatile oil from ginger rhizomes (Zingiber officinale), its fractions and isolated compounds on the 5-HT3 receptor complex and the serotoninergic system of the rat ileum. Planta Med.2007; 73:355–62. https://doi.org/10.1055/s-2007-967171 PMid:17511060

Jiang X, Williams KM, Liauw WS, et al. Effect of ginkgo and ginger on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects. Br J Clin Pharmacol.2005; 59:425–32. https://doi.org/10.1111/j.13652125.2005.02322.x PMid:15801937 PMCid:PMC1884814

Krüth P, Brosi E, Fux R, et al. Ginger-associated over anticoagulation by phenprocoumon. Ann Pharmacother.2004; 38:257–60. https://doi.org/10.1345/aph.1D225 PMid:14742762

Shalansky S, Lynd L, Richardson K, et al. Risk of warfarin-related bleeding events and supratherapeutic international normalized ratios associated with complementary and alternative medicine: A longitudinal analysis. Pharmacotherapy. 2007; 27:1237–47. https://doi.org/10.1592/phco.27.9.1237 PMid:17723077

Spolarich AE, Andrews L. An examination of the bleeding complications associated with herbal supplements, antiplatelet and anticoagulant medications. J Dent Hyg JDH Am Dent Hyg Assoc. 2007; 81:67.

Yamahara J, Miki K, Chisaka T, et al. Cholagogic effect of ginger and its active constituents. J Ethnopharmacol. 1985; 13:217–25. https://doi.org/10.1016/0378-8741(85)900091


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