Comparative Study on Myelotoxic and Antineoplastic Action of Synadenium umbellatum, Vitis vinifera and Resveratrol

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Authors

  • Laboratório de Análises Clí­nicas da Faculdade de Medicina do ABC, Av Principe de Gales, 821, CEP 09060-650, Santo André, Sào Paulo ,BR
  • Departamento de Ciíªncias Farmacíªuticas da Universidade Federal de Sào Paulo, Diadema, Sào Paulo ,BR
  • Departamento de Ciíªncias Farmacíªuticas da Universidade Federal de Sào Paulo, Diadema, Sào Paulo ,BR
  • Laboratório de Análises Clí­nicas da Faculdade de Medicina do ABC, Av Principe de Gales, 821, CEP 09060-650, Santo André, Sào Paulo ,BR
  • Laboratório de Análises Clí­nicas da Faculdade de Medicina do ABC, Av Principe de Gales, 821, CEP 09060-650, Santo André, Sào Paulo ,BR
  • Departamento de Ciíªncias Farmacíªuticas da Universidade Federal de Sào Paulo, Diadema, Sào Paulo ,BR
  • Departamento de Ciíªncias Farmacíªuticas da Universidade Federal de Sào Paulo, Diadema, Sào Paulo ,BR
  • Departamento de Farmacologia da Faculdade de Ciíªncias Farmacíªuticas da UNICAMP, Campinas, Sào Paulo ,BR
  • Laboratório de Análises Clí­nicas da Faculdade de Medicina do ABC, Av Principe de Gales, 821, CEP 09060-650, Santo André, Sào Paulo ,BR
  • Laboratório de Análises Clí­nicas da Faculdade de Medicina do ABC, Av Principe de Gales, 821, CEP 09060-650, Santo André, Sào Paulo ,BR
  • Laboratório de Análises Clí­nicas da Faculdade de Medicina do ABC, Av Principe de Gales, 821, CEP 09060-650, Santo André, Sào Paulo ,BR

DOI:

https://doi.org/10.18311/jnr/2019/23383

Keywords:

Antineoplastics, Drug Toxicity, Phytotherapy.

Abstract

Cancer is one of the pathologies that most challenge medicine, not only because of the complexity of its development, but also because of the difficulty of treatment that is not always effective. Due to the significant toxicity and adverse effects profile presented by the main chemotherapeutic agents used to treat neoplasm, there is a constant interest in the search for new drugs that may be a more effective alternative. Therefore, the search for new compounds of plant origin becomes an interesting tool for the discovery of drugs with antitumor activity. Synadenium umbellatum is a plant native to tropical Africa known as "cola-nota", "hazel", "cancerous", "miraculous", among others. The plant is used by the Brazilian population as having anti-inflammatory, analgesic, antineoplastic properties, among others. However, the literature is lacking on reports of the toxicity of Synadenium umbellatum macerate. Resveratrol is a polyphenolic compound found in different plant species, mainly in grape species (Vitis) and their seeds. Vitis vinifera is a species of grape easily found in several regions, also containing a high concentrations of phenolic compounds, including resveratrol in its fruits, leaves and seeds. Therefore, this study was aimed to evaluate the myelotoxicity of macerate, extract and resveratrol and their antitumor activity in Balb/c mice with Ehrlich tumor. The hematological evaluation was obtained by flow cytometry and the tumors were measured using a pachymeter and the tumor masses by means of weighing. No statistically significant difference was observed between results from the control group and the treatment groups. It was concluded that macerate, crude extract and resveratrol did not demonstrate a myelotoxic effect and did not cause a decrease in tumor mass.

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Published

2019-06-24

How to Cite

da Silva, E. B., Chagas, C. S., Oliveira, M. P. A., Fonseca, A. L. A., Alves, B. da C. A., Bagatin, I., Perazzo, F. F., Rosa, P., Feder, D., Petri, G., & Fonseca, F. L. A. (2019). Comparative Study on Myelotoxic and Antineoplastic Action of <i>Synadenium umbellatum</i>, <i>Vitis vinifera</i> and Resveratrol. Journal of Natural Remedies, 19(2), 80–86. https://doi.org/10.18311/jnr/2019/23383

Issue

Section

Research Articles
Received 2019-03-07
Accepted 2019-06-07
Published 2019-06-24

 

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