Invitro Anti-Mutagenic Potential of Potentilla fulgens: a Western Himalayan Plant


Affiliations

  • Central University of Punjab, Centre for Chemical and Pharmaceutical Sciences, School of Basic and Applied Sciences, Bathinda, 151001, India
  • Guru Nanak Dev University, Department of Botanical and Environmental Sciences, Amritsar, Punjab, 143001, India

Abstract

Invitro anti-mutagenic potential of different extracts/fractions of Potentilla fulgens has been made by an Ames histidine reversion assay using TA98 and TA100 tester strains of Salmonella typhimurium against the direct-acting mutagens, 4-Nitro-O-phenylenediamine (NPD) and Sodium azide. P. fulgens has been used in traditional system of medicine as anti-hyperglycemic, hypoglycemic, anti-hyperlipidemic, anti-oxidant, anti-inflammatory and anti-ulcerogenic agent. Results indicated that n-butanol and water fractions showed strong inhibition activity against the mutagens (NPD, Sodium azide) in both co-incubation as well as pre-incubation treatments in TA98 and TA100 tester strains.

Keywords

Co-Incubation, Inhibition, Mutation, Potentilla fulgens, Pre-Incubation.

Subject Discipline

Pharmacy and Pharmacology

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