Efficacy of Vitamin E against Cigarette Smoke Induced Alterations in Pulmonary Tissue, Serum Enzymes and Lipid Profile in Albino Rats

B. S. Sharma; Nibha Rathore; Asha Agarwal

doi:10.18311/jeoh/2012/1741

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Authors

B. S. Sharma
Department of Environmental Studies, School of Life Sciences, Dr. B.R. Ambedkar University, Khandari Campus, Agra-282002 ,IN
Nibha Rathore
Department of Environmental Studies, School of Life Sciences, Dr. B.R. Ambedkar University, Khandari Campus, Agra-282002 ,IN
Asha Agarwal
Department of Zoology, School of Life Sciences, Dr. B.R. Ambedkar University, Khandari Campus, Agra-282002 ,IN

DOI:

https://doi.org/10.18311/jeoh/2012/1741

Keywords:

Cigarette Smoke, Albino Rat, Lung Histopathology, SGPT, SGOT, SALP, Serum Lipid Profile, Antioxidant Vitamin E.

Abstract

The present study was designed to evaluate the protective role of vitamin E(50mg/kg bwt) against adverse effects of cigarette smoke (60 and 120 days) on lung tissue , serum enzyme activity and lipid profile in male albino rats. Reduction in the histopathological changes like emphysema, pulmonary edema, debris, capillary permeability and thick epithelium have been seen after supplementation of vitamin E in comparison to cigarette smoke exposed rats. Decrease in serum enzyme activity viz. SGPT (P<0.05), SGOT (P>0.05) and SALP (P<0.05) and serum lipid profile-serum cholesterol (P>0.05), serum triglycerides (P<0.05), LDL (P>0.05) and VLDL (P<0.05) with corresponding increase in HDL level (P>0.05) have also reported after pre-exposure supplementation of vitamin E in comparison to cigarette smoke exposed rats. Vitamin E is able to mitigate the toxic effects of cigarette smoke on albino rats.