Fertility Activity of Wedelia trilobata Linn. Leaf Extracts on Female Wister Albino Rats


Affiliations

  • Bharath College of Science and Management, Thanjavur (Affiliated to Bharathidasan University, Tiruchirappalli), PG and Research Department of Biotechnology, Thanjavur, Tamil Nadu, 613005, India
  • Kongunadu Arts and Science College, Department of Zoology, Coimbatore, Tamil Nadu, India

Abstract

Wedelia trilobata Linn., Asteraceae, is a creeping evergreen perennial herb. It is native to the tropics of Central America and has naturalized in many wet tropical and subtropics areas of the world. It is widely used in traditional medicine for the treatment of contraceptives, rheumatoid arthritis, diabetes, infertility and impotence. The present study evaluated the potential fertility effect of aqueous and ethanolic extract of leaves of Wedelia trilobata Linn. Anti-oxidant activity of the leaves was determined and the antimicrobial activity was performed for the urinary bacteria of females. In animal experiment, Group 1 served as negative control given only olive oil, Group 2 and 3 were given with 200 mg/kg and 400 mg/ kg of Aqueous extract of W. trilobata, Group 4 and 5 – 3 was given with 200 mg/kg and 400 mg/kg of ethanolic extract of W. trilobata, Group 6 and 7 were given 1mg/kg and 2 mg/ kg of drug. The results revealed the promising anti-oxidant and anti-microbial activity and the aqueous treated rats shown similar activity compared to the control rat. The contraceptive nature of the rats was determined through the hormonal reports.

Keywords

Anti-Microbial, Anti-Oxidant, Fertility Activity, Wedelia trilobata Linn, Wister Albino Rats

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References

Ghosh K, Bhattacharya TK. Preliminary study on the anti-implantation activity of compounds from the extracts of seeds of Thespesia populnea. Indian J Pharmacol. 2004; 36(5):288–91.

Aitken RJ, Baker MA, Doncel GF, Matzuk MM, Mauck CK, Harper MJK. As the world grows: Contraception in the 21st century. J Clin Investig. 2008; 118(4):1330–43. https://doi.org/10.1172/JCI33 873. PMid:18382745 PMCid:PMC2276786

Negi S, Dwivedi I, Setty BS, Ray S. Benzophenones, naphthophenones and related compounds as spermicidal agents. Indian J Pharm Sci. 1994; 56(3):105–8.

Bagul MS, Kanaki NS, Rajani M. Evaluation of free radical scavenging properties of two classical polyherbal formulations. Indian J Exp Biol. (2005); 43(8):732–6.

Govindappa M, Sravya SN, Poojashri MN, Sadananda TS, Chandrappa CP. Antimicrobial, antioxidant and in vitro anti-inflammatory activity of ethanol extract and active phytochemical screening of Wedelia trilobata (L.) Hitchc. J Pharmacogn Phytotherapy. 2011; 3(3):43–51 https://doi.org/10.5530/pj.2011.25.15

George H, Teng CM, Wu CL, Ko FN. Marchantin H as a natural antioxidant and free radical scavenger. Arch of Biochem and Biophys. 1996; 334:18–26. https://doi.org/10.1006/abbi.1996.0424. PMid:8837734

Hassan S, El-Twab SA, Hetta M, Mahmoud B. Improvement of lipid profile and antioxidant of hypercholesterolemic albino rats by polysaccharides extracted from the green alga Ulva lactuca Linnaeus. Saudi J Biol Sci. 2011; 18:333–40. https://doi.org/10.1016/j.sjbs.2011.01.005. PMid:23961145 PMC id:PMC3730952

Mzid M, Khedir SB, Salem MB, Regaieg W, Rebai T. Antioxidant and antimicrobial activities of ethanol and aqueous extracts from Urtica urens. Pharm Biol. 2017; 55(1):775–81. https://doi.org/10.1080/13880209.2016.1275025. PMid:28084125 PMCid:PMC6130501

Kefas M, Abubakar KA, Jaafaru. Haematological indices of tilapia (Oreochromis niloticus) from Lake Geriyo, Yola, Adamawa State, Nigeria. J Fish Aquat Sci. 2015; 3(1): 09–14.

Uotilo M, Rouslahti E, Engvali EJ. Two sites and which enzyme immuno assay with monoclonal antibodies to humans. J Immunol Methods. 1981; 42:11–15.


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