Impaired Wound Healing Due to Cyclophosphamide (CLP) Alleviated by Supplemental Ginkgo biloba (GB)

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  • ,IN
  • ,IN
  • ,IN
  • ,IN

DOI:

https://doi.org/10.18311/jnr/2006/276

Keywords:

Dead Space Wounds, Excision Wounds, Granulation Tissue, Hydroxyproline
Therapeutic Drug Monitoring

Abstract

Objective: To evaluate whether the extract of Ginkgo biloba (GB) could reverse the healing suppressant effect of Cyclophosphamide(CLP). Methods: The wound healing effects of CLP (12.6 mg/kg/ IP single dose on 3'd post wounding day) and GB (50 mg/kg IP) daily were tested on dead space and excision wound models in male rats. Results: CLP has significantly (p<0.05) reduced and GB has significantly(p<0.05) increased the breaking strength and hydroxyproline content of granulation tissue in dead space wounds. GB has significantly (p<0.01) reversed the suppressant effect of CLP. In case of excision wounds there was no change in wound contraction and epithelization period by CLP, GB or GB+CLP when compared to control. Conclusion: The healing suppressant effect of CLP was reversed by co-administration of GB. This effect of GB may due to its antioxidant property.

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Published

2006-01-01

How to Cite

Bairy, K. L., Ganesh, S. B., Adiga, M. S., & Shalini, A. (2006). Impaired Wound Healing Due to Cyclophosphamide (CLP) Alleviated by Supplemental <I>Ginkgo biloba</I> (GB). Journal of Natural Remedies, 6(1), 31–34. https://doi.org/10.18311/jnr/2006/276

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