Effect of Different Galactomannans on Absorption of Cholesterol in Rabbits

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Authors

  • ,IN
  • ,IN

DOI:

https://doi.org/10.18311/jnr/2006/284

Keywords:

Galactomannans, Galactose, Mannose Ratio, Antihyperlipidemic Activity
Therapeutic Drug Monitoring

Abstract

Objective: The aim of the present investigation was to study the effect of different galactomannans on cholesterol absorption in rabbits. Materials and methods: Guar, fenugreek and locust bean galactomannans of # 200 having different galactose: mannose ratios of 1:2, 1:1 and 1:4 respectively and 1%w/v aqueous dispersion of these galactomannans having viscosities of 3215 ± 280 cps, 1050 ± 80 cps and 600 ± 52 cps respectively were selected for the present study. Antihyperlipidemic activity of galactomannans was studied using cholesterol loaded rabbit model. Cholesterol was administered by gastric gavage in a daily dose of 500mg/kg bodyweight, for induction of hyperlipidemia. The different galactomannans were administered in a daily dose of 250 mg/kg body weight. The study was carried out for a period of 18 days. Blood specimens were collected before commencement of study, on day 9 and on the last day. The total lipid profile in serum was determined using auto-analyzer. Results: All the three galactomannans under study showed significant antihyperlipidemic activity (p<0.05) in comparison to the control group. Guar and fenugreek galactomannans had statistically (p<0.05) a similar effect. Locust bean galactomannan had significantly (p<0.05) a lower activity in comparison to the other two galactomannans. The effects of galactomannans so observed can be explained and correlated with their galactose: mannose ratios i.e. galactomannans with a high galactose: mannose ratio like fenugreek and guar have a better effect in comparison to a galactomannan with low galactose: mannose ratio like locust bean. Conclusion: It is concluded that different galactomannans having different galactose: mannose ratios affect the absorption of cholesterol to different extent.

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Published

2006-01-01

How to Cite

Issarani, R., & Nagori, B. P. (2006). Effect of Different Galactomannans on Absorption of Cholesterol in Rabbits. Journal of Natural Remedies, 6(1), 83–86. https://doi.org/10.18311/jnr/2006/284

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