Phytochemical Analysis by HR-LCMS and <i>In vitro</i> Anti-diabetic Potential of <i>Michelia champaca</i> Bark

Authors

  • Segu Prathyusha Department of Pharmacognosy, School of Pharmacy, GNITC, Hyderabad – 501506, Telangana
  • Malarkodi Velraj Department of Pharmacognosy, VELS Institute of Science, Technology and Advanced studies, Chennai – 600117, Tamil Nadu

DOI:

https://doi.org/10.18311/jnr/2022/29798

Keywords:

HR – LCMS, Antidiabetic, <i>Michelia champaca</i>, Bark, β-amylase, β-glucosidase

Abstract

The current analysis was aimed to study the phytochemical profile and in vitro antidiabetic capacity of HEMC bark. HR-LCMS1 was used to identify the phytochemicals present in the extract. The outcomes of HR-LCMS showed the presence of 15 phytochemical compounds. DL-Carnitine, Catechin, D-β-Tocopherol, Colchicine, Myricetin, Epicatechin, Quercetin, Epigallocatechin gallate, Quercetin-3β-D-glucoside, Kaempferol, Sorbic acid, Apocynin, Epigallocatechin gallate, myricetin 3-O-beta-D-galactopyranoside, Naringeninchalcone are the main compounds identified. The inhibition of enzymes like β-amylase and β-glucosidase delays the rate of glucose absorption thus reducing blood glucose levels in the experimental models. The IC50 values of β-amylase and β-glucosidase inhibitory activity of HEMC were acquired to be 88.65 ?g/mL and 71.28 ?g/mL correspondingly. Positive control acarbose displayed IC50 assessment of 52.94 ?g/mL and 50.01 ?g/mL correspondingly. Consequently, the current study confirms that HEMC had remarkable antidiabetic activity and hence holds future potential as nutraceuticals in the treatment of diabetes and related ailments.

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Published

2022-07-30

How to Cite

Prathyusha, S., & Velraj, M. (2022). Phytochemical Analysis by HR-LCMS and <i>In vitro</i> Anti-diabetic Potential of <i>Michelia champaca</i> Bark. Journal of Natural Remedies, 22(3), 432–439. https://doi.org/10.18311/jnr/2022/29798

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Research Articles

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