Traditional Indian Medicinal Plants for the Treatment of Psoriasis: A Review of Active Constituents and their Pharmacological Effects

Jump To References Section

Authors

  • Faculty of Pharmaceutical Science, Assam Down Town University, Sankar Madhab Path, Gandhinagar, Panikhaiti, Guwahati - 781026, Assam ,IN
  • Department of Pharmaceutical Sciences, School of Medical Sciences, Adamas University, Barrackpore- Barasat Road, Kolkata - 700126, West Bengal ,IN
  • School of Pharmaceutical Sciences, University of Science and Technology Meghalaya, Baridua, RiBhoi - 793101, Meghalaya ,IN
  • Royal School of Pharmacy, The Assam Royal Global University, Betkuchi, Guwahati - 781035, Assam ,IN
  • Royal School of Pharmacy, The Assam Royal Global University, Betkuchi, Guwahati - 781035, Assam ,IN
  • Netaji Subhas Chandra Bose Institute of Pharmacy, Chakdaha, Nadia - 741222, West Bengal ,IN
  • Faculty of Pharmaceutical Science, Assam Down Town University, Sankar Madhab Path, Gandhinagar, Panikhaiti, Guwahati - 781026, Assam ,IN

DOI:

https://doi.org/10.18311/jnr/2023/33241

Keywords:

Active Constituents, Mechanism, Medicinal Plants, Pharmacology, Psoriasis

Abstract

Psoriasis is a chronic inflammatory skin disease that affects millions of people worldwide. The use of natural products for the treatment of psoriasis has gained interest due to their potential to modulate the immune system and reduce inflammation. Traditional Indian medicinal plants offer a promising source of natural products for the treatment of psoriasis. This article provides a comprehensive review of Indian medicinal plants that have been traditionally used for the treatment of psoriasis, along with their active constituents and reported pharmacological activities. In addition, we discuss the molecular pharmacology of psoriasis and the limitations of current allopathic treatment methods. Finally, we highlight the potential therapeutic effects of individual active constituents found in Indian medicinal plants, with a focus on their anti-inflammatory, antioxidant, and immunomodulatory properties. This review provides a basis for further research on the use of traditional Indian medicinal plants for the treatment of psoriasis.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Downloads

Published

2023-08-31

How to Cite

Sarkar, D., Das, S., Kalita, P., Jyoti Pathak, B., Judder, M. I., Datta, K., & Alam, F. (2023). Traditional Indian Medicinal Plants for the Treatment of Psoriasis: A Review of Active Constituents and their Pharmacological Effects. Journal of Natural Remedies, 23(3), 785–790. https://doi.org/10.18311/jnr/2023/33241

Issue

Section

Short Review
Received 2023-03-06
Accepted 2023-06-27
Published 2023-08-31

 

References

Lowes MA, Suárez-Fariñas M, Krueger JG. Immunology of psoriasis. Annu. Rev. Immunol. 2014; 32:227–55. https://doi.org/10.1146/annurevimmunol- 032713-120225 PMid:24655295 PMCid: PMC4229247 DOI: https://doi.org/10.1146/annurev-immunol-032713-120225

Yan B-X, et al. Cutaneous and systemic psoriasis: Classifications and classification for the distinction. Front. Med. 2021; p. 8. https://doi. org/10.3389/fmed.2021.649408 PMid:34722555 PMCid:PMC8548430 DOI: https://doi.org/10.3389/fmed.2021.649408

Gupta RS, Chaudhary R, Yadav RK, Verma SK, Dobhal MP. Effect of saponins of Albizia lebbeck (L.) Benth bark on the reproductive system of male albino rats. J. Ethnopharmacol. 2005; 96:31–6. https://doi. org/10.1016/j.jep.2004.07.025 PMid:15588647 DOI: https://doi.org/10.1016/j.jep.2004.07.025

Kurd SK, et al. Oral curcumin in the treatment of moderate to severe psoriasis vulgaris: A prospective clinical trial. J. Am. Acad. Dermatol. 2008; 58:625– 631. https://doi.org/10.1016/j.jaad.2007.12.035 PMid: 18249471 PMCid:PMC4131208 DOI: https://doi.org/10.1016/j.jaad.2007.12.035

Andreicuț AD, et al. Antitumoral and immunomodulatory effect of mahonia aquifolium extracts. Oxid. Med. Cell. Longev.2019; 2019: 6439021. https://doi.org/10.1155/2019/6439021 PMid: 31949880 PMCid: PMC6948282 DOI: https://doi.org/10.1155/2019/6439021

Nordin UUM, Ahmad N, Salim N, Yusof NSM. Lipidbased nanoparticles for psoriasis treatment: A review on conventional treatments, recent works, and future prospects. RSC Adv. 2021; 11:29080. https://doi. org/10.1039/D1RA06087B PMid:35478537 PMCid: PMC9038133 DOI: https://doi.org/10.1039/D1RA06087B

Gisondi P, Bellinato F, Girolomoni G, Albanesi C. Pathogenesis of chronic plaque psoriasis and its intersection with cardio-metabolic comorbidities. Front. Pharmacol. 2020; 11. https://doi.org/ 10.3389/fphar.2020.00117 PMid:32161545 PMCid: PMC7052356 DOI: https://doi.org/10.3389/fphar.2020.00117

Hawkes JE, Yan BY, Chan TC, Krueger JG. Discovery of the IL-23/IL-17 signaling pathway and the treatment of psoriasis. J. Immunol. 2018; 201:1605– 1613. https://doi.org/10.4049/jimmunol.1800013 PMid:30181299 PMCid:PMC6129988 DOI: https://doi.org/10.4049/jimmunol.1800013

Leung DYM, Berdyshev E, Goleva E. Cutaneous barrier dysfunction in allergic diseases. J. Allergy Clin. Immunol. 2020; 145:1485–1497. https://doi. org/10.1016/j.jaci.2020.02.021 PMid:32507227 PMCid: PMC7291847 DOI: https://doi.org/10.1016/j.jaci.2020.02.021

Orsmond A, Bereza-Malcolm L, Lynch T, March L, Xue M. Skin barrier dysregulation in psoriasis. Int. J. Mol. Sci. 2021; 22:10841. https://doi.org/10.3390/ ijms221910841 PMid:34639182 PMCid:PMC8509518 DOI: https://doi.org/10.3390/ijms221910841

Pleńkowska J, Gabig-Cimińska M, Mozolewski P. Oxidative stress as an important contributor to the pathogenesis of psoriasis. Int. J. Mol. Sci. 2020; 21:6206. https://doi.org/10.3390/ijms21176206 PMid: 32867343 PMCid:PMC7503883 DOI: https://doi.org/10.3390/ijms21176206

Briganti S, Picardo M. Antioxidant activity, lipid peroxidation and skin diseases. What’s new. J. Eur. Acad. Dermatol. Venereol. 2003; 17:663–69. https://doi.org/10.1046/j.1468-3083.2003.00751.x PMid:14761133 DOI: https://doi.org/10.1046/j.1468-3083.2003.00751.x

Zhou Q, Mrowietz U, Rostami-Yazdi M. Oxidative stress in the pathogenesis of psoriasis. Free Radic. Biol. Med. 2009; 47:891–905. https://doi.org/10.1016/j. freeradbiomed.2009.06.033 PMid:19577640 DOI: https://doi.org/10.1016/j.freeradbiomed.2009.06.033

Tsoi LC, et al. Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants. Nat. Commun. 2017; 8:15382.

Kurutas EB. The importance of antioxidants which play the role in cellular response against oxidative/ nitrosative stress: current state. Nutr. J. 2016; 15:71. https://doi.org/10.1186/s12937-016-0186-5 PMid:27456681 PMCid:PMC4960740 DOI: https://doi.org/10.1186/s12937-016-0186-5

Yadav UCS, Ramana KV. Regulation of nf - induced inflammatory signaling by lipid peroxidation-derived aldehydes. Oxid. Med. Cell. Longev. 2013; e690545. https://doi.org/10.1155/2013/690545 PMid:23710287 PMCid:PMC3654319 DOI: https://doi.org/10.1155/2013/690545

Daniyal M, et al. Progress and prospects in the management of psoriasis and developments in phyto-therapeutic modalities. Dermatol. Ther. 2019; 32:e12866. https://doi.org/10.1111/dth.12866 PMid: 30838736 DOI: https://doi.org/10.1111/dth.12866

Lebwohl M, Ting PT, Koo JYM. Psoriasis treatment: Traditional therapy. Ann. Rheum. Dis. 2005; 64:ii83– ii86. https://doi.org/10.1136/ard.2004.030791 PMid: 15708945 PMCid:PMC1766882 DOI: https://doi.org/10.1136/ard.2004.030791

Uva L, et al. Mechanisms of action of topical corticosteroids in psoriasis. Int. J. Endocrinol. 2012; 2012:e561018. https://doi.org/10.1155/2012/561018 PMid:23213332 PMCid:PMC3508578 DOI: https://doi.org/10.1155/2012/561018

Coondoo A, Phiske M, Verma S, Lahiri K. Sideeffects of topical steroids: A long overdue revisit. Indian Dermatol. Online J. 2014; 5:416–25. https:// doi.org/10.4103/2229-5178.142483 PMid:25396122 PMCid:PMC4228634 DOI: https://doi.org/10.4103/2229-5178.142483

Soleymani T, Hung T, Soung J. The role of vitamin D in psoriasis: A review. Int. J. Dermatol. 2015; 54:383–92. https://doi.org/10.1111/ijd.12790 PMid:25601579 DOI: https://doi.org/10.1111/ijd.12790

Chandraratna RAS. Tazarotene: The first receptorselective topical retinoid for the treatment of psoriasis. J. Am. Acad. Dermatol. 1997; 37:S12–S17. https://doi. org/10.1016/S0190-9622(97)80395-7 DOI: https://doi.org/10.1016/S0190-9622(97)80395-7

Hsieh CY,Tsai TF. Management of coexisting bullous pemphigoid and psoriasis: a review. Am. J. Clin. Dermatol. 2022; 23:869–79. https://doi.org/10.1007/ s40257-022-00719-7 PMid:35964277 DOI: https://doi.org/10.1007/s40257-022-00719-7

Balogh EA, Bashyam AM, Ghamrawi RI, Feldman SR. Emerging systemic drugs in the treatment of plaque psoriasis. Expert Opin. Emerg. Drugs. 2020; 25:89–100. https://doi.org/10.1080/14728214.2020.1 745773 PMid:32192366 DOI: https://doi.org/10.1080/14728214.2020.1745773

De Camargo MC, et al. Adverse events in patients with rheumatoid arthritis and psoriatic arthritis receiving long-term biological agents in a real-life setting. Front. Pharmacol. 2019; 10. https://doi. org/10.3389/fphar.2019.00965 PMid:31572173 PMCid:PMC6749844 DOI: https://doi.org/10.3389/fphar.2019.00965

Sharma HK, Chhangte L, Dolui AK. Traditional medicinal plants in Mizoram, India. Fitoterapia. 2001; 72:146–161. https://doi.org/10.1016/S0367- 326X(00)00278-1 PMid:11223224 DOI: https://doi.org/10.1016/S0367-326X(00)00278-1

Alam A. et al. Allium vegetables: Traditional uses, phytoconstituents, and beneficial effects in inflammation and cancer. Crit. Rev. Food Sci. Nutr. 2022; 0:1–35. https://doi.org/10.1080/10408398.2022. 2036094 PMid:35170391

Singh S. Ethno botanical study of some wild herb species Parsa District Forest of Nepal. J. Pharmacogn. Phytochem. 2015; 4:32–40.

Akbar S. Senna tora (L.) Roxb. (Fabaceae/ Leguminosae). in Handbook of 200 Medicinal Plants: A Comprehensive Review of Their Traditional Medical Uses and Scientific Justifications. 2020; 1649– 1655. https://doi.org/10.1007/978-3-030-16807-0 DOI: https://doi.org/10.1007/978-3-030-16807-0_170

Padalia K, Bargali K, Bargali SS. How does traditional home-gardens support ethnomedicinal values in Kumaun Himalayan Bhabhar belt, India? Afr. J. Tradit. Complement. Altern. Med. 2015; 12:100–112. https://doi.org/10.21010/ajtcam.v12i6.10 DOI: https://doi.org/10.21010/ajtcam.v12i6.10

Kunnumakkara AB, et al. Googling the guggul (commiphora and boswellia) for prevention of chronic diseases. Front. Pharmacol.2018; 9. https:// doi.org/10.3389/fphar.2018.00686 PMid:30127736 PMCid:PMC6087759 DOI: https://doi.org/10.3389/fphar.2018.00686

Anand U, Jacobo-Herrera N, Altemimi A, Lakhssassi N. A comprehensive review on medicinal plants as antimicrobial therapeutics: Potential avenues of biocompatible drug discovery. Metabolites. 2019; 9:258. https://doi.org/10.3390/metabo9110258 PMid: 31683833 PMCid:PMC6918160 DOI: https://doi.org/10.3390/metabo9110258

Kumari I, Kaurav H, Chaudhary G. Eclipta alba (bhringraj): A promising hepatoprotective and hair growth stimulating herb. Asian J. Pharm. Clin. Res. 2021; 16–23. https://doi.org/10.22159/ajpcr.2021. v14i7.41569 DOI: https://doi.org/10.22159/ajpcr.2021.v14i7.41569

Al-Fatimi M. Ethnobotanical survey of medicinal plants in central Abyan governorate, Yemen. J. Ethnopharmacol. 2019; 241:111973. https://doi. org/10.1016/j.jep.2019.111973 PMid:31146001 DOI: https://doi.org/10.1016/j.jep.2019.111973

Nandy S, Mukherjee A, Pandey DK, Ray P Dey A. Indian sarsaparilla (Hemidesmus indicus): Recent progress in research on ethnobotany, phytochemistry and pharmacology. J. Ethnopharmacol. 2020; 254:112609. https://doi.org/10.1016/j.jep.2020.112609 PMid: 32007632 DOI: https://doi.org/10.1016/j.jep.2020.112609

Singh DK, Luqman S, Mathur AK. Lawsonia inermis L. – A commercially important primaeval dying and medicinal plant with diverse pharmacological activity: A review. Ind. Crops Prod. 2015; 65:269–286. https://doi.org/10.1016/j.indcrop.2014.11.025 DOI: https://doi.org/10.1016/j.indcrop.2014.11.025

Ravinder K. Ethnobotanical Studies on Karnal District, Haryana, India. 2014; p. 3.

Gautam RK, et al. Perspective of plant medicine in therapy of rheumatoid arthritis. Indian J. Pharm. Sci. 2020; 82:741–765. https://doi.org/10.36468/ pharmaceutical-sciences.703 DOI: https://doi.org/10.36468/pharmaceutical-sciences.703

Maurya S, Seth A. Potential medicinal plants and trditional ayaurvedic approach towards Urticaria, an allergic skin disorder. Int. J. Pharm. Pharm. Sci. 2014; 6.

Kumar R, Gupta YK, Singh S, Raj A. Anti-inflammatory effect of Picrorhiza kurroa in experimental models of inflammation. Planta Med. 2016; 82:1403– 1409. https://doi.org/10.1055/s-0042-106304 PMid:27163229 DOI: https://doi.org/10.1055/s-0042-106304

Al-Harrasi A, Bhatia S, Chigurupati S, Behl T, Kaushik D. Plant profile, phytochemistry, and ethnopharmacological uses of Swertia chirayita, Tribulus terrestris and Plumbago zeylanica. Recent Advances in Natural Products Science (CRC Press, 2022). https://doi.org/10.1201/9781003274124-5 DOI: https://doi.org/10.1201/9781003274124

Shrestha S, et al. Pharmacognostical evaluation of Psoralea corylifolia Linn. seed. J. Ayurveda Integr. Med. 2018; 9:209–212 https://doi.org/10.1016/j. jaim.2017.05.005 PMid:30121145 PMCid: PMC6148055 DOI: https://doi.org/10.1016/j.jaim.2017.05.005

Razavi BM, Ghasemzadeh Rahbardar M, Hosseinzadeh H. A review of therapeutic potentials of turmeric (Curcuma longa) and its active constituent, curcumin, on inflammatory disorders, pain, and their related patents. Phytother. Res. 2021; 35:6489–6513. https://doi.org/10.1002/ptr.7224 PMid:34312922 DOI: https://doi.org/10.1002/ptr.7224

Bahraini P, et al. Turmeric tonic as a treatment in scalp psoriasis: A randomized placebo-control clinical trial. J. Cosmet. Dermatol. 2018; 17:461–466. https:// doi.org/10.1111/jocd.12513 PMid:29607625 DOI: https://doi.org/10.1111/jocd.12513

Katsimbri P, et al. The effect of antioxidant and anti-inflammatory capacity of diet on psoriasis and psoriatic arthritis phenotype: Nutrition as therapeutic tool? Antioxidants. 2021; 10:157. https:// doi.org/10.3390/antiox10020157 PMid:33499118 PMCid: PMC7912156 DOI: https://doi.org/10.3390/antiox10020157

Hou D-D, et al. Anti-inflammatory effects of quercetin in a mouse model of MC903-induced atopic dermatitis. Int. Immunopharmacol. 2019; 74:105676. https://doi.org/10.1016/j.intimp.2019.105676 PMid: 31181406 DOI: https://doi.org/10.1016/j.intimp.2019.105676

Lanzilli G, et al. Anti-inflammatory effect of resveratrol and polydatin by in vitro il-17 modulation. Inflammation. 2012; 35:240–248. https://doi. org/10.1007/s10753-011-9310-z PMid:21369944 DOI: https://doi.org/10.1007/s10753-011-9310-z

Buhaș MC, et al. Gut microbiota in psoriasis. Nutrients. 2022; 14:2970. https://doi.org/10.3390/ nu14142970 PMid:35889927 PMCid:PMC9321451 DOI: https://doi.org/10.3390/nu14142970

Aggarwal BB, Shishodia S. Suppression of the nuclear factor-κb activation pathway by spice-derived phytochemicals: Reasoning for seasoning. Ann. N. Y. Acad. Sci. 2004; 1030:434–441. https://doi. org/10.1196/annals.1329.054 PMid:15659827 DOI: https://doi.org/10.1196/annals.1329.054

Raghuwanshi N, et al. Structure-based drug designing and identification of Woodfordia fruticosa inhibitors targeted against heat shock protein (HSP70-1) as suppressor for Imiquimod-induced psoriasis like skin inflammation in mice model. Mater. Sci. Eng. 2019; C95:57–71. https://doi.org/10.1016/j. msec.2018.10.061 PMid:30573271 DOI: https://doi.org/10.1016/j.msec.2018.10.061

Martins AM, Ascenso A, Ribeiro HM, Marto J. The brain–skin connection and the pathogenesis of psoriasis: A review with a focus on the serotonergic system. 2020; Cells9:796. https://doi.org/10.3390/ cells9040796 PMid:32224981 PMCid:PMC7226493 DOI: https://doi.org/10.3390/cells9040796

Huang TH, Lin CF, Alalaiwe A, Yang SC, Fang JY. Apoptotic or antiproliferative activity of natural products against keratinocytes for the treatment of psoriasis. Int. J. Mol. Sci. 2019; 20:2558. https://doi. org/10.3390/ijms20102558 PMid:31137673 PMCid: PMC6566887 DOI: https://doi.org/10.3390/ijms20102558

Most read articles by the same author(s)