Evaluation of Hibiscus sabdariffa Aerial Parts against Pyloric Ligation-induced Ulcers in Experimental Rats

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Authors

  • V. V. Rajesham
     CMR College of Pharmacy, Kandlakoya (V), Medchal Road, Hyderabad - 501401, Telangana ,IN
  • Mitta Raghavendra
     Department of Pharmaceutical Sciences, School of Biotechnology and Pharmaceutical Sciences, Vignan’s Foundation for Science, Technology and Research, Guntur - 522213, Andhra Pradesh ,IN
  • G. Supriya Reddy
     CMR College of Pharmacy, Kandlakoya (V), Medchal Road, Hyderabad - 501401, Telangana ,IN
  • P. Roshan Ali
     CMR College of Pharmacy, Kandlakoya (V), Medchal Road, Hyderabad - 501401, Telangana ,IN
  • T. Rama Rao
     CMR College of Pharmacy, Kandlakoya (V), Medchal Road, Hyderabad - 501401, Telangana ,IN

DOI:

https://doi.org/10.18311/jnr/2024/35163

Keywords:

Anti-ulcer Activity, Hibiscus sabdariffa, Lansoprazole, Pylorus Ligation, Ulcer Index

Abstract

The sloughing off inflammatory dead tissue is characteristic of ulcers, which are open sores of the skin or mucous membrane. Peptic ulcers are erosive lesions on the stomach or duodenal lining. The drive of the study was to evaluate the effectiveness of Hibiscus sabdariffa aerial parts extracts against pylorus ligation-induced ulcers. The extracts were prepared by maceration using ethanol and double distilled water. In the treatment schedule, Groups A and B were considered negative and standard (Lansoprazole 8 mg/kg b. wt, p.o.) controls. Groups C, D, E, and F as low (200 mg/kg b. wt, p.o.) and high (400 mg/kg b. wt, p.o.) dose treatment groups, received EEHS and AEHS, respectively. Gastric content, pH, free and total acidity, ulcer index, and inhibition of ulcer (%) were assessed. Following administration of both extracts, measurements of stomach content, free and total acidity, and ulcer index decreased. Additionally, pH increased, and a greater percentage of ulcers were inhibited. It was discovered that the ethanolic extract had significantly higher anti-ulcer action than the aqueous extract.

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Published

2024-05-01

How to Cite

Rajesham, V. V., Raghavendra, M., Supriya Reddy, G., Roshan Ali, P., & Rama Rao, T. (2024). Evaluation of <i>Hibiscus sabdariffa</i> Aerial Parts against Pyloric Ligation-induced Ulcers in Experimental Rats. Journal of Natural Remedies, 24(5), 1135–1140. https://doi.org/10.18311/jnr/2024/35163

Issue

Volume 24, Issue 5, May 2024

Section

Short Communication

License

Copyright (c) 2024 V. V. Rajesham, Mitta Raghavendra, G. Supriya Reddy, P. Roshan Ali, T. Rama Rao (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Europe PMC
Received 2023-09-21
Accepted 2024-03-15
Published 2024-05-01

 

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