Exploring the Anti-obesity Properties of Corn Silk Extract (CornFit®) in C57BL/6 Mice Induced with Obesity via a High-Fat Diet

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Authors

  • H. N. Shivaprasad
     Research and Development Centre, Botanic Healthcare Pvt. Ltd., TSIIC Industrial Development Area, Nacharam, Uppal, Hyderabad - 500076, Telangana ,IN
  • Gaurav Soni
     Research and Development Centre, Botanic Healthcare Pvt. Ltd., TSIIC Industrial Development Area, Nacharam, Uppal, Hyderabad - 500076, Telangana ,IN
  • Madhu Krishnamani
     Research and Development Centre, Botanic Healthcare Pvt. Ltd., TSIIC Industrial Development Area, Nacharam, Uppal, Hyderabad - 500076, Telangana ,IN
  • T. Sravani
     Research and Development Centre, Botanic Healthcare Pvt. Ltd., TSIIC Industrial Development Area, Nacharam, Uppal, Hyderabad - 500076, Telangana ,IN
  • Machiraju Garaga
     Research and Development Centre, Botanic Healthcare Pvt. Ltd., TSIIC Industrial Development Area, Nacharam, Uppal, Hyderabad - 500076, Telangana ,IN
  • D. Manohar
     Research and Development Centre, Botanic Healthcare Pvt. Ltd., TSIIC Industrial Development Area, Nacharam, Uppal, Hyderabad - 500076, Telangana ,IN

DOI:

https://doi.org/10.18311/jnr/2024/36556

Keywords:

Anti-adipogenic, Inflammation, Lipogenic, Metabolic Health, Zea mays

Abstract

Objective: The impact of CornFit®, an extract derived from corn silk was assessed on obesity-induced mice subjected to a High-Fat Diet (HFD). Methods: C57BL/6 mice were assigned to seven groups: normal control, HFD control, reference standard and four CornFit® dosage groups. Body weight, food intake, fat mass and metabolic parameters were assessed throughout the study. Biochemical markers, gene expression in liver tissue and histopathological analysis were also performed. Results: Supplementation with CornFit® notably decreased body weight gain, fat mass and enhanced lipid profile compared to the HFD group. It also decreased pro-inflammatory markers and insulin levels while increasing adiponectin and leptin, indicating anti-inflammatory and metabolic benefits. RT-PCR analysis revealed downregulation of lipogenic genes and upregulation of genes involved in fatty acid metabolism and energy expenditure. Liver function tests and organ weights improved in treated groups. Conclusion: CornFit® demonstrates promising anti-obesity potential by reducing fat accumulation, improving metabolic health and modulating related gene expression.

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Published

2024-07-31

How to Cite

Shivaprasad, H. N., Soni, G., Krishnamani, M., Sravani, T., Garaga, M., & Manohar, D. (2024). Exploring the Anti-obesity Properties of Corn Silk Extract (CornFit®) in C57BL/6 Mice Induced with Obesity via a High-Fat Diet. Journal of Natural Remedies, 24(7), 1561–1569. https://doi.org/10.18311/jnr/2024/36556

Issue

Volume 24, Issue 7, July 2024

Section

Research Articles

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Copyright (c) 2024 H. N. Shivaprasad, Gaurav Soni, Madhu Krishnamani, T Sravani, Machiraju Garaga, D. Manohar (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Received 2024-02-13
Accepted 2024-06-26
Published 2024-07-31

 

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