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Evaluation of Antipyretic and Anti-inflammatory Activity of Aqueous Extract of Leptadenia Reticulata in Animal Models


Affiliations

  • Gokaraju Rangaraju College of Pharmacy, Department of Pharmacology, Bachupally, Hyderabad, Andhra Pradesh, 500090, India
  • Gokaraju Rangaraju College of Pharmacy, Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Bachupally, Hyderabad, Andhra Pradesh, 500090, India

Abstract

Objective: To study the antipyretic and anti-inflammatory effects of the Aqueous Extract of Leptadenia Reticulata (AELR) in different animal models. Materials and Methods: Acute toxicity studies were performed and extract was found to be safe upto 2000 mg/kg. Two doses were selected for the "evaluation of antipyretic and anti-inflammatory activity of aqueous extract of Leptadenia reticulata in animal models" i.e 200 mg/kg and 400 mg/kg b. w. Antipyretic activity was evaluated using baker's yeast induced pyrexia in albino rats and cow milk induced pyrexia in albino rabbits. Anti-inflammatory activity was evaluated using carrageenan induced paw edema and turpentine oil induced paw edema in albino rats. Results: In all the animal models AELR at the dose of 200 mg/kg b.w and 400 mg/kg b.w showed significant (P<0.01) antipyretic and anti-inflammatory activity. Conclusion: These finding could justify the inclusion of aqueous extract of Leptadenia reticulata in the management of pyrexia and inflammation.

Keywords

Baker's Yeast, Cow Milk, Carrageenan, Leptadenia reticulata, Turpentine Oil

Subject Discipline

Pharmacy and Pharmacology

Full Text:

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