Journal of Pierre Fauchard Academy (India Section)

Steroids as a Boon in Oral Pemphigus Vulgaris: A Case Report and Treatment Overview


Affiliations

  • Government Dental College and Hospital, Mumbai, Department of Oral Pathology, Maharashtra, India
  • Center for Dental Education and Research (AIIMS), Department of Oral Pathology and Microbiology, New Delhi, India
  • SDKS Dental College and Hospital, Department of Oral Pathology and Microbiology, Nagpur, Maharashtra, India
  • Dr. HSRSM's Dental College and Hospital, Department of Oral Pathology and Microbiology, Hingoli, Maharashtra, India
  • Saraswati-Dhanwantari Dental College and Hospital, Department of Oral Pathology and Microbiology, Parbhani, Maharashtra, India
  • Ministry of Health, Bahrain

Abstract

Pemphigus vulgaris (PV) is an autoimmune blistering disease characterized by circulating pathogenic IgG autoantibodies against desmoglein 3 and desmoglein 1. Oral lesions readily rupture, new bullae developing as the older ones rupture and ulcerate. Oral lesions may precede cutaneous lesions in 53.52% cases. Prompt recognition and diagnosis is critical since it may prevent cutaneous involvement. Systemic steroids remain the gold standard treatment of PV. Their use has transformed what was almost invariably a fatal illness into one whose mortality is now below 10%. We report a case of patient with oral ulcers since 4 months, who is diagnosed with PV without cutaneous involvement.

Keywords

Corticosteroids, Mucous membrane, Oral ulcer, Pemphigus vulgaris

Subject Discipline

Dentistry

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References

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