Heat Shock Proteins In Pathology: A Review


  • Bhojia Dental College and Hospital, Department of Oral Pathology and Microbiology, HP, India
  • Bhojia Dental College and Hospital, Department of Conservative Dentistry & Endodontics, Himachal Pradesh, India
  • Bhojia Dental College and Hospital, HP, India


Heat shock proteins of the 70 kDa family (HSPAs/HSP70s) are major molecular chaperones and cytokines of most cells and microbes, extracellular and interstitial fluids, blood, synovial fluids and secretory body fluids like saliva. The induction of human HSPAs plays an important role at cellular level under most stress conditions. HSPAs play a role in numerous physiological and pathological events, including modulation of cytokine release and immunity. Despite their advantageous effects maintaining health of several oral tissues, HSPAs are likely to play a role in the progression of pathological conditions like OLP, OSMF and Carcinogenesis. The review attempts to provide a critical overview of Hsps and their divergent roles in cellular processes particularly in the context of human health and disease.


Hsps, OLP, OSMF, Carcinogenesis

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Bakthisaran R, Tangirala R, Rao M. Small heat shock proteins: role in cellular functions and pathology. J Biochem Biophys Acta. 2015;1854:291–319.

Pockley AG. Heat shock proteins as regulators of immune response. Lancet. 2003 http://image.thelancet.com/extras/ 02art9148we.pdf.

Wang Y, Whittall T, McGowan E, et al. Identification of stimulating and inhibitory epitopes within the heat shock protein 70 molecule that modulate cytokine production and maturation of dendritic cells. J Immunol. 2005;174:3306–3316.

Fabian TK, Gaspar J, Fejerdy L, et al. Hsp70 is present in human saliva. Med Sci Monitor. 2003;9:BR62–BR65. PMID: 12552239.

Fábián TK, Tóth ZS, Fejérdy L, Kaán B, Csermely P, Fejérdy P. Photo-acoustic stimulation increases the amount of 70 kDa heat shock protein (Hsp70) in human whole saliva. A pilot study. Int J Psychophysiol. 2004;52:211–216.

Shelburne CE, Coulter WA, Olguin DA, Lantz MS, Lopatin DE. Induction of b-defensin resistance in the oral anaerobe Porphyromonas gingivalis. Antimicr Agent Chemother. 2005;49:183–187.

Amemiya H, Matsuzaka K, Kokubu E, Ohta S, Inoue T. Cellular responses of rat periodontal ligament cells under hypoxia and reoxygenation conditions in vitro. J Periodontal Res. 2008;43:322–327.

Amano T, Muramatsu T, Amemiya K, Kubo K, Shimono M. Responses of rat pulp cells to heat stress in vitro. J Dent Res. 2006;85:432–435.

Fábián TK, Fejérdy P, Nguyen MT, Sőti C, Csermely P. Potential immunological functions of salivary Hsp70 in mucosal and periodontal defense mechanisms. Arch Immunol Ther Exp. 2007;55:91–98.

Fábián TK, Sőti C, Nguyen MT, Csermely P, Fejérdy P. Expected functions of salivary HSP70 in the oral cavity. In: Morel E, Vincent C, eds. In: Heat Shock Proteins: New Research. New York: Nova Science Publishers, Inc.; 2008:321–340.

Asea A. Stress proteins and initiation of immune response: chaperokine activity of Hsp70. Exerc Immunol Rev. 2005; 11:34–35.

Calderwood SK, Mambula SS, Gray Jr PJ, Theriault JR. Extracellular heat shock proteins in cell signaling (Minireview). FEBS Lett. 2007;581:3689–3694.

Kampinga HH, Hageman J, Vos MJ, et al. Guidelines for the nomenclature of the human heat shock proteins. Cell Stress Chaperones. 2009;14:105–111.

Suzuki T, Kumamoto H, Ooya K, Motegi K. Expression of inducible nitric oxide synthase and heat shock proteins in periapical inflammatory lesions. J Oral Pathol Med. 2002;31:488–493.

Nair SP, Meghji S, Reddi K, Poole S, Miller AD, Henderson B. Molecular chaperones stimulate bone resorption. Calcif Tissue Int. 1999;64:214–218.

Fábián TK, Csermely P, Fábián G, Fejérdy P. Spondyloarthropathies and bone resorption. Possible role of heat shock protein 70 (Hsp70). Acta Physiol Hung. 2009;96:149–155.

Ikai H, Tamura T, Watanabe T, et al. Low intensity pulsed ultrasound accelerates periodontal wound healing after flap surgery. J Periodontal Res. 2008;43:212–216.

Novak N, Haberstok J, Bieber T, Allam JP. The immune privilege of the oral mucosa. Trends Mol Med. 2008;14:191–198.

Fábián TK, Singh M, Csermely P, Sőti C. Bacterial binding and opsonizing effect of extracellular Hsp70. FEBS J. 2008;275 (S):460.

Heyden G, Arwill T, Gisslen H. Histochemical studies on lichen planus. Oral Surg Oral Med Oral Pathol. 1974;37:239–248.

Tyagi N, Shetty DC, Urs AB. Altered expression of HSP70 in oral lichen planus. J Oral Maxillofac Pathol. 2012;16:189–194.

Thubashini M, Malathi N, Kannan L. Expression of heat shock protein70 in oral submucous fibrosis and oral squamous cell carcinoma: an immunohistochemical study. Indian J Dent Res. 2011;22:256–259.

Tupakri JV, Bhavathankar JD, Mandale MS. Oral submucous fibrosis. A study of 100 cases. J Indian Acad Oral Med Radiol. 2007;19:311–318.

More C, Asrani M, Patel H, Adalja C. Oral submucous fibrosis – a hospital-based retrospective study. Pearldent. 2010;1:25–31.

Nylandsted J, Wick W, Hirt UA, et al. Eradication of glioblastoma, and breast colon carcinoma xenografts by Hsp70 depletion. Cancer Res. 2002;62:7139–7142;ĆHulkko SM, Wakui H, Zilliacus J. The pro-apoptotic protein deathassociated protein 3 (DAP3) interacts with the glucocorticoid receptor and affects the receptor function. Biochem J. 2000;349:885–893.

Nardai G, Csermely P, Soti C. Chaperone function and chaperone overload in the aged. Exp Gerontol. 2002;37:1257–1262.

Soti C, Csermely P. Chaperones and aging: their role in neurodegeneration and other civilizational diseases. Neurochem Int. 2002;41:383–389.


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