Study of Serum Alkaline Phosphatase Levels among Psoriasis Patients and Comparative Group in Tertiary Care Institute

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Authors

  • Associate Professor, Department of Dermatology, Dr. Vasantrao Pawar Medical College Hospital & RC, Nashik – 422003, Maharashtra ,IN
  • PG Resident, Department of Dermatology, Dr. Vasantrao Pawar Medical College Hospital & RC, Nashik – 422003, Maharashtra ,IN
  • Professor and Head, Department of Dermatology, Dr. Vasantrao Pawar Medical College Hospital & RC, Nashik – 422003, Maharashtra ,IN
  • Senior Resident, Department of Dermatology, Dr. Vasantrao Pawar Medical College Hospital & RC, Nashik – 422003, Maharashtra ,IN
  • Assistant Professor, Department of Dermatology, Dr. Vasantrao Pawar Medical College Hospital & RC, Nashik – 422003, Maharashtra ,IN

DOI:

https://doi.org/10.18311/mvpjms/2018/v5i2/18268

Keywords:

Alkaline Phosphatase, Oxidative Stress, Psoriasis
Psoriasis

Abstract

Background: Psoriasis is a chronic relapsing autoimmune skin disease of unknown etiology, characterised by complex alterations in epidermal growth and differentiation. Oxidative stress is a known risk factor for exacerbation of psoriasis. Serum alkaline phosphatase level is a marker of oxidative stress in body. Aims and Objectives: To study and compare serum alkaline phosphatase levels in cases of psoriasis. Materials and Methods: Serum Alkaline Phosphatase levels were evaluated in 100 cases of psoriasis and controls. Results: There was no statistically significant difference between serum alkaline phosphatase levels among cases and controls. Conclusion: Serum alkaline phosphatase levels, as a marker of oxidative stress is not significantly raised in cases of psoriasis.

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Published

2019-04-17

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Original Research Article

 

References

Nickoloff BJ, Nestle FO. Recent insights into the immunopathogenesis of psoriasis provide new therapeutic opportunities, J. Clin. Invest. 2004; 113:1664−75.

Dogra S, Yadav S. Psoriasis in India: Prevalence and pattern, Indian J. Dermatol. Venerol. Leprol. 2010; 76:595−601.

Bedi TR. Clinical profile of psoriasis in North India, Indian J. Dermatol. Venereol. Leprol. 1995; 61:202−5.

Kaur I, Handa S, Kumar B. Natural history of psoriasis: A study from the Indian subcontinent, J. Dermatol. 1997; 24:230−4.

Malligarjunan H, Gnanaraj P, Subramanian S, Elango T, Dayalan H. Clinical efficacy of propylthiouracil and its influence on prolactin in psoriatic patients, Clin. Biochem. 2011 Oct; 44(14-15):1209−13. Epub. 2011 Jul 28. https://doi.org/10.1016/j.clinbiochem.2011.07.009.

Smith AE, Kassab JY, Rowland Payne CME, Beur WE. Bimodality in age of onset of psoriasis in both patients and relatives, Dermatology. 1993; 186:181−86.

Pavithran K, Karunakaran M, Aparna P, Raghunatha S. PsoariasisIn: Valia RG, Valia AR. EDS. Disorders of keratinization. IADVL textbook of dermatology. Third edition. Volume 1, reprint. Bhalani publishing house; 2012. 30, p. 1021−56.

Gudjonsson JE, Elder JT. Psoriasis. In: Goldsmith LA, Katz SI, Gilchrest, Paller AS, Leffell DJ, Wolff K. Eds. Fitzpatrick Dermatology in General Medicine. Eighth edition. Volume I; 2008. 18, p. 197−231.

Griffiths CEM, Barker JNWN. Psoriasis In: Tony B, Stephen B, Neil C, Christopher G. editors. Rook textbook of dermatology, Eighth edition. Volume 1, Wiley-Blackwell; 2010. 20, p. 1−20.

Peter Cm, Kerkhof vd, Nestle FO. Psoriasis In: Bolognia JL, Jorizzo JL, Schaffer JV, Eds. Dermatology, Third edition. Elsevier; 2008. p. 135−56.

Smith CH, Anstey AV, Barker JN et al. British Association of Dermatologists guidelines for use of biological intervention in psoriasis, Br J Dermatol. 2005; 153:486−97.

David H. Vroon, Zafar Israili. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd Edition.

Oxidative Medicine and Cellular Longevity. 2016 (2016). Article ID 8490643, p. 7.

Bhatnagar M, Bapna A, Khare A K. Serum proteins, trace metals and phosphatases in psoriasis, Indian J. DermatolVenereol. Leprol. 1994; 60:18−2

Franck H, Ittel T. Serum osteocalcin levels in patients with psoriatic arthritis: An extended report, Rheumatol Int. 2000; 19(5):161−4

Nestle FO et al. Skin immune sentinels in health and disease, Nat. Rev. Immunol. 2009; 9(10):679−91.

Sheikh G, Masood Q, Majeed S, Hassan I. Comparison of levels of serum copper, zinc, albumin, globulin and alkaline phosphatase in psoriatic patients and controls: A hospital based case control study, Indian Dermatol. Online J. 2015 Mar-Apr; 6(2):81−3. https://doi.org/10.4103/22295178.153006.

Enerback C, Martinsson T, Inerot A, Wahlstrom J, Enlund F, Yhr M, Swanbeck G. Evidence that HLA-cw6 determines early onset of psoriasis, obtained using sequence-specific primers (PCR-SSP), Acta. Dermatovenerologica. 1997; 77(4):273−76.

Cohen A D, Gilutz H, Henkin Y, Zahger D, Shapiro J, Bonneh D Y, Vardy D A. Psoriasis and the Metabolic Syndrome. ActaDermVenereol 2007; 87: 506–509.

https://doi.org/10.2340/00015555-0297.

Madanagobalane S, Anandan S. Prevalence of metabolic syndrome in south Indian patients with psoriasis vulgar is and the relation between disease severity and metabolic syndrome: A hospital-based case-control study, Indian J. Dermatol. 2012; 57:353−7.

Golov KG, Varshavskić­ VA, OkunevDIu, Neverov NI, Shestakova MV, Proskurneva FP. Urinary enzymes in the assessment of the early stage of kidney involvement in psoriasis and diabetes mellitus, Ter. Arkh. 1995; 67(10):80−1 (Russian).

McMillan EM, Rowe D. Plasma zinc in psoriasis: relation to surface area involvement, Br. J. Dermatol. 1983 Mar; 108(3):301−05. PubMed PMID: 6830695.