Safety Assessment of Cefquinome Following Multiple Intramuscular Administration Regarding Haematology of Cow Calves


Abstract

The present study was carried out to investigate haematological alterations induced after repeated intramuscular administration of cefquinome at the dose rate of 2 mg.kg-1 body weight in five healthy male cow calves. Blood samples were collected before administration of the drug which served as control (day 0). After administration of drugs, blood samples were collected at day 1st, 2nd, 3rd, 4th, 5th and 6th from jugular vein into Ethylene Diaminetetraacetic Acid Tripotassium Salt (K3EDTA) coated vacutainers for haematological parameters (Hemoglobin, Packed cell volume, total leukocyte count and differential leukocyte count) analysis. The results of the study clearly demonstrated that repeated intramuscular administration of cefquinome in therapeutic doses produced non-significant difference (p<0.05) in values of haematological parameters in cow calves when compared with control values (0 day). Lack of clinical signs of adverse reactions and absence of significant difference in haematological parameters following intramuscular administration, may open a new avenue for insight into the strategy for clinical treatment of various bacterial diseases in cow calves.

Keywords

Cefquinome, Cow Calves, Safety Study, Cephalosporin, Antibiotic.

Subject Discipline

Pharmacy and Pharmacology

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