Safety Assessment of Lincomycin Following Repeated Intramuscular Administration in Goats

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Authors

  • Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, GADVASU, Ludhiana-141004 ,IN
  • Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, GADVASU, Ludhiana-141004 ,IN
  • Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, GADVASU, Ludhiana-141004 ,IN
  • Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, GADVASU, Ludhiana-141004 ,IN
  • Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, GADVASU, Ludhiana-141004 ,IN

Keywords:

Goats, Lincomycin, Safety Assessment.

Abstract

A safety evaluation of lincomycin was carried out to assess clinical impact of intramuscular administration of lincomycin on various haematological and biochemical parameters in goats to establish safety profile of lincomycin. Six healthy female goats were treated with single intramuscular dose of lincomycin @10.0 mg/kg body weight. The blood samples were collected at day 0 (before administration of drugs), and on 6th day of drug administration. The hematological and plasma biochemical analysis were done. No significant alterations (p < 0.05) were found in the mean value of haematological and biochemical parameters during treatment period except for significant elevation in values of Lactate dehydrogenase and Creatinine. Repeated intramuscular administration of lincomycin (10.0 mg/kg) for 5 days in goat was found safe. Thus, lincomycin may be useful to treat bacterial diseases accompanied by fever, pain and other inflammatory condition in goats.

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Published

2015-12-01

How to Cite

Singla, S., Dumka, V. K., Sharma, M., Lonare, M. K., & Sharma, S. K. (2015). Safety Assessment of Lincomycin Following Repeated Intramuscular Administration in Goats. Toxicology International, 22(3), 92–95. Retrieved from https://informaticsjournals.com/index.php/toxi/article/view/20518

Issue

Section

Original Research

 

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