Genotoxicity evaluation of human populations exposed to radio frequency radiation

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Authors

  • Rekhadevi P. V.
     Toxicology Unit, Biology Division, Indian Institute of Chemical Technology, Hyderabad - 500 007, Andhra Pradesh ,IN
  • Sailaja N.
     Toxicology Unit, Biology Division, Indian Institute of Chemical Technology, Hyderabad - 500 007, Andhra Pradesh ,IN
  • M. Mahboob
     Toxicology Unit, Biology Division, Indian Institute of Chemical Technology, Hyderabad - 500 007, Andhra Pradesh ,IN
  • Rahman M. F.
     Toxicology Unit, Biology Division, Indian Institute of Chemical Technology, Hyderabad - 500 007, Andhra Pradesh ,IN
  • Grover P.
     Toxicology Unit, Biology Division, Indian Institute of Chemical Technology, Hyderabad - 500 007, Andhra Pradesh ,IN

Keywords:

Chromosomal aberrations, Comet assay, Genetic effect, Micronucleus test, Mobile telephones

Abstract

In the modern day life, mobile telephones have become an integral part for mutual communication. Virtually most people are exposed to radio frequency radiation. In the current study a group of 55 subjects with regular cell phone usage and an equal number of well-matched control individuals were studied. The possible genetic changes in lymphocytes of cellular telephone users were assessed with the comet assay, micronucleus test and chromosomal aberrations analysis. In addition micronucleus test on buccal epithelial cells was also carried out in the same subjects. The results suggested that in the mobile phone users there was a statistically significant increase in mean DNA damage when compared to controls. Similar result was observed with micronucleus test and chromosomal aberrations analysis also (P<0.05). Age, smoking and alcohol consumption did not have any significant effect on genetic damage when analyzed by comet assay. However, no association of gender, age, smoking and alcohol consumption on micronucleus frequency was observed. Smoking and alcohol consumption had significant effect by the chromosomal aberration test (P<0.05). The results of this study indicated that the genetic damage of peripheral lymphocytes and buccal epithelial cells in the mobile telephone users increased significantly, as compared with controls.

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Published

2018-04-05

How to Cite

P. V., R., N., S., Mahboob, M., M. F., R., & P., G. (2018). Genotoxicity evaluation of human populations exposed to radio frequency radiation. Toxicology International, 16(1), 09–19. Retrieved from https://informaticsjournals.com/index.php/toxi/article/view/20837

Issue

Volume 16, Issue 1, January-April 2009

Section

Original Research
Received 2018-04-05
Accepted 2018-04-05
Published 2018-04-05

 

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