Protective Effect of Psidium guajava in Arsenic-induced Oxidative Stress and Cytological Damage in Rats

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Authors

  • ,IN
  • ,IN
  • ,IN
  • ,IN

Keywords:

Histopahtology, oxidative stress, Psidium guajava, rats, sodium arsenite

Abstract

This study was undertaken to evaluate the protective effect of aqueous extract of Psidium guajava leaves against sodium arsenite-induced toxicity in experimental rats. Animals were divided into four groups. Control group received arsenic free distilled water and three treatment groups (II, III, and IV) exposed to the arsenic (NaAsO2) (20 mg/kg b.wt) through drinking water. Group III and IV were administered a daily oral dose of P. guajava leaf extract 50 and 100 mg/kg b.wt. (AEPG50 and AEPG100) for the period of 6 weeks. Blood samples and organs were collected at the end of the experiment. Arsenic exposure resulted in significant rise in lipid peroxidation (LPO) levels in erythrocyte, liver, kidney, and brain. In addition toxin decreased (P100 (aqueous extract of P. guajava) @100 mg/kg body weight) significantly restored activities of oxidative stress markers like LPO levels, GSH levels, SOD, and CAT activities but having the limited protective activity of the herbal extract was observed on tissues architecture. It is therefore concluded that prophylactic co-administration of AEPG could provide specific protection from oxidative injury and to some extent on tissue damage.

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Published

2018-08-14

How to Cite

Tandon, N., Roy, M., Roy, S., & Gupta, N. (2018). Protective Effect of Psidium guajava in Arsenic-induced Oxidative Stress and Cytological Damage in Rats. Toxicology International, 19(3), 245–249. Retrieved from https://informaticsjournals.com/index.php/toxi/article/view/21755

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Section

Original Research
Received 2018-08-14
Accepted 2018-08-14
Published 2018-08-14

 

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