Antidepressants Medications and the Relative Risk of Suicide Attempt

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Authors

  • R. A. Mandour
     ,EG

Keywords:

Blood samples, antidepressant drug, EMIT

Abstract

This study was conducted on patients (n=1283) of different ages, 924 males and 359 female. These patients were attended to poison unit at emergency hospital, Mansoura University during the period from January 2002 to December 2009. The aim of this study was to characterize patients on antidepressants after self-poisoning with suicidal intent regarding age, sex, type of current antidepressant therapy, and type of substances ingested in order to commit suicide. During the study period, 175 Para suicide patients were found with current antidepressants therapy and presented with self-poisoning using their antidepressant therapy or other medications. A substantial difference between different types of antidepressants was found. Para suicide risks for selective serotonin reuptake inhibitor were significantly low than those of tricyclic antidepressants, so in suicide prevention, risks and benefits of an antidepressant should be taken into account when choosing treatment for depressive patients. At the same time, depressed patients should be under close psychiatric assessment in order to prevent such possible suicidal attempts.

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Published

2018-08-21

How to Cite

Mandour, R. A. (2018). Antidepressants Medications and the Relative Risk of Suicide Attempt. Toxicology International, 19(1), 42–46. Retrieved from https://informaticsjournals.com/index.php/toxi/article/view/21843

Issue

Volume 19, Issue 1, January- April 2012

Section

Original Research
Received 2018-08-21
Accepted 2018-08-21
Published 2018-08-21

 

References

Simon OR, Swann AC, Powell KE, Potter LB, Kresnow MJ, O'Carroll PW. Characteristics of impulsive suicide attempts and attempters. Suicide Life Threat Behav 2001;32(1 Suppl);49-59.

Maris RW. Suicide. Lancet 2002;360:319-26.

Fergusson DM, Woodward LJ, Horwood LJ. Risk factors and life processes associated with the onset of suicidal behaviour during adolescence and early adulthood. Psychol Med 2000;30:23-39.

Dieserud G, Loeb M, Ekeberg O. Suicidal behavior in the municipality of Baerum, Norway: A 12-year prospective study of para suicide and suicide. Suicide Life Threat Behav 2000;30:61-73.

Kapur S, Mieczkowski M, Mann J. Antidepressants medications and the relative risk of suicide attempt and suicide. J Am Med Assoc 1992;268:3441-5.

Paykel ES. Clinical efficacy of reversible and selective inhibitors of monoamine oxidase A in major depression. Acta Pshyctri Scand Suppl 1995;386:22-7.

Bertolote JM, Fleischmann A, De Leo D, Wasserman D. Suicide and mental disorders: Do we know enough? Br J Psychiatry 2003;183:382-3.

Henry J, Alexander CA, Sener EA. Relative mortality from overdose of antidepressants. BMJ 1995;310:221-4.

De Hert M, McKenzie K, Peuskens J. Risk factors for suicide in young people suffering from schizophrenia: A long term followup study. Schizophr Res 2001;47,127-34.

Isacsson G, Holmgren P, Druid H, Bergman U. The utilization of antidepressants- a key issue in the prevention of suicide: An analysis of 5281 suicides in Sweden during the period 19921994. Acta Psychiatr Scand 1997;96:94-100.

Gokay B, Ercan A, Ibrahim A, Goksel K, Mevlut T, Fatma OS, et al. "Clastogenicity of selective serotonin reuptake inhibitors mutations research”. Genet Toxicol Environ Mutagen 2004;558:137-44.

Altamura C, VanGastel A, Pioli R, Mannu P, Maes M. Seasonal and circadian rhyms in suicide in Cagliari, Italy. J Affect Disord 1999;53:77-85.

Bille-Brahe U, Kerkhof A, De Leo D, Schmidtke A, Crepet P, Lonnqvist J, et al. A repetition-prediction study of European Para suicide populations: A summary of the first report from part II of the WHO/EURO multicoated study on Parasuicide in co-operation with the EC concerted action on attempted suicide.Acta Psychiatr Scand 1997;95:81-6.

Schmidtke A, Bille-Brahe U, DeLeo D, Kerkhof A, Bjerke T, Crepet P, et al. Attempted suicide in Europe: Rates, trends and sociodemolgraphic characteristics of suicide attempters during the period 1989-1992. Results of the WHO/EURO Multicentre study on Parasuicide. Acta Psychiatr Scand 1996;93;327-38.

American Psychiatric Association practice guideline for assessment and treatment of patients with suicidal behaviors.Am J Psychiatry 2003;60(11 suppl):1-60.

Montgomry SA, Kasper S. Comparison of compliance between serotonin reuptake inhibitors and tricyclic antidepressants.a meta-analysis. Int Clin Psychopharmacol 1995;9 Suppl 4:33-40.

Rutz W, Wålinder J, von Knorring L, Rihmer Z, Pihlgren H.Prevention of depression and suicide by education and medication: Impact on male suicidailty. An update from the Gotland study. Int J Psychiatry Clin Pract 1997;1;39-46.

Hotopf M, Hardy R, Lewis G. Discontinuation rates of SSRIs andTCAs: A meta-analysis and investigation of heterogeneity. Br J Psychiatry 1997;170:120-7.