Toxic Effects of Sub-Chronic Oral Exposure of Imidacloprid on Biochemical Parameters in Buffalo Calves

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Authors

  • Tsewang Dorjay
     Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana – 141 004, Punjab ,IN
  • Rajdeep Kaur
     Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana – 141 004, Punjab ,IN
  • S. P. S. Saini
     Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana – 141 004, Punjab ,IN
  • H. S. Sandhu
     Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana – 141 004, Punjab ,IN

DOI:

https://doi.org/10.18311/ti/2020/v27i3&4/22489

Keywords:

Biochemical, Buffalo Calves, Imidacloprid, Subchronic

Abstract

Imidacloprid, is a highly effective and widely used neonicotinoid insecticide for crop protection and veterinary pest control, which has gained a major market control in the past several years. The present investigation was undertaken to evaluate the toxic potential of imidacloprid in buffalo calves when administered for prolonged periods. Evaluation of various biochemical markers of hepatic, renal and muscular injury was done using standardized procedures. Oral administration of imidacloprid (@ 0.5 mg/kg/day; 90 days) in male buffalo calves, produced varying degrees of nasal discharge, lachrymal discharge, lethargy and weakness. Imidacloprid exposure caused a significant increase in the levels of plasma aspartate aminotransferase (12.3%), alanine aminotransferase (172.2%), lactate dehydrogenase (13.7%), gamma-glutamyltranspeptidase (57.5%), alkaline phosphatase (37.2%), acid phosphatase (220.0%), blood urea nitrogen (148.4%), creatinine (5.22%) and cholesterol (68.9%). However, no significant changes were observed in the enzymatic activity of creatine kinase, plasma cholinesterase as well as total protein and glucose levels.

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Published

2022-08-12

How to Cite

Dorjay, T., Kaur, R., Saini, S. P. S., & Sandhu, H. S. (2022). Toxic Effects of Sub-Chronic Oral Exposure of Imidacloprid on Biochemical Parameters in Buffalo Calves. Toxicology International, 27(3&4), 86–92. https://doi.org/10.18311/ti/2020/v27i3&4/22489

Issue

Volume 27, Issue 3&4, July-December 2020

Section

Research Articles
Crossref
Scopus
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Europe PMC
Received 2018-10-11
Accepted 2018-11-02
Published 2022-08-12

 

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