Nanocurcumin Restores Arsenic-Induced Disturbances in Neuropharmacological Activities in Wistar Rats


  • Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal Sciences University, Veterinary College, Hebbal, Bengaluru - 560024, Karnataka
  • Veterinary College, Vinobanagar, Shivamogga – 577204, Karnataka
  • Department of Veterinary Pharmacology and Toxicology, Veterinary College, Bidar – 585226, Karnataka
  • Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal Sciences University, Veterinary College, Hebbal, Bengaluru - 560024, Karnataka
  • Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal Sciences University, Veterinary College, Hebbal, Bengaluru - 560024, Karnataka
  • Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal Sciences University, Veterinary College, Hebbal, Bengaluru - 560024, Karnataka
  • Department of Veterinary Pathology, Veterinary College, Hebbal, Bengaluru – 560024, Karnataka
  • Department of Veterinary Pharmacology and Toxicology, Veterinary College, Vinobanagar, Shivamogga – 577204, Karnataka
  • Department of Veterinary Pathology, Veterinary College, Hebbal, Bengaluru – 560024, Karnataka
  • Department of Veterinary Pathology, Veterinary College, Vinobanagar, Shivamogga – 577204, Karnataka
  • Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal Sciences University, Veterinary College, Hebbal, Bengaluru - 560024, Karnataka
  • Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal Sciences University, Veterinary College, Hebbal, Bengaluru - 560024, Karnataka



Arsenic, Redox home ostasis, Neuropharmacology, Nano curcumin, Wistar rats


The present study was carried out to examine the ameliorative potential of nanocurcumin against arsenic induced (sub-chronic) alterations in central nervous system in male Wistar rats. Nanocurcumin was synthesised and the hydrodynamic diameter, zeta potential and particle size were~76.60 nm, (-) 30 mV and 95nm, respectively. Experimental rats sub-chronically exposed to sodium (meta) arsenite (As; 10; 70 days; p.o) induced significant (p<0.05) reduction in superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione and favoured free radical generation and induced lipid peroxidation in brain tissue. The exposure resulted in significant (p<0.05) decrease in voluntary- and involuntary motor activities and enhanced anxiety levels. However, experimental rats receiving nanocurcumin (15; p.o) showed significant (p<0.05) recovery in enzymatic - and non-enzymatic antioxidant defence system and restoration of redox balance and overcome arsenic induced depression in motor activities and elevated anxiety levels. Further, Arsenic induced elevation in pro-inflammatory cytokines, cyclooxygenase-2 activity and prostaglandin-E2 in brain and angiotensin-II levels (plasma) was significantly (p<0.05) ameliorated by nanocurcumin. Additionally, quantitative real -time polymerase chain reaction revealed a fivefold decrease in Nox2 expression in brain following nanocurcumin administration. Thus, the study concludes that nanocurcumin can serve as a potential therapeutic candidate to counter arsenic induced redox imbalance and neuropharmacological disturbances and there exists a vast scope to exploit its utility after appropriate clinical modelling.


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How to Cite

Nithyashree, N., Prakash, N., Waghe, P., Santhosh, C. R., Pavithra, B. H., Rajashekaraiah, R., Sathyanarayana, M. L., Sunilchandra, U., Anjan Kumar, K. R., Manjunatha, S. S., Muralidhar, Y., & Shivaprasad, G. R. (2022). Nanocurcumin Restores Arsenic-Induced Disturbances in Neuropharmacological Activities in Wistar Rats. Toxicology International, 29(3), 429–445.



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