Nanocurcumin Restores Arsenic-Induced Disturbances in Neuropharmacological Activities in Wistar Rats

Authors

  • N. Nithyashree
     Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal Sciences University, Veterinary College, Hebbal, Bengaluru - 560024, Karnataka
  • N Prakash
     Veterinary College, Vinobanagar, Shivamogga – 577204, Karnataka
  • Prashantkumar Waghe
     Department of Veterinary Pharmacology and Toxicology, Veterinary College, Bidar – 585226, Karnataka
  • C. R. Santhosh
     Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal Sciences University, Veterinary College, Hebbal, Bengaluru - 560024, Karnataka
  • B. H. Pavithra
     Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal Sciences University, Veterinary College, Hebbal, Bengaluru - 560024, Karnataka
  • Rashmi Rajashekaraiah
     Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal Sciences University, Veterinary College, Hebbal, Bengaluru - 560024, Karnataka
  • M. L. Sathyanarayana
     Department of Veterinary Pathology, Veterinary College, Hebbal, Bengaluru – 560024, Karnataka
  • U. Sunilchandra
     Department of Veterinary Pharmacology and Toxicology, Veterinary College, Vinobanagar, Shivamogga – 577204, Karnataka
  • K. R. Anjan Kumar
     Department of Veterinary Pathology, Veterinary College, Hebbal, Bengaluru – 560024, Karnataka
  • S. S. Manjunatha
     Department of Veterinary Pathology, Veterinary College, Vinobanagar, Shivamogga – 577204, Karnataka
  • Y. Muralidhar
     Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal Sciences University, Veterinary College, Hebbal, Bengaluru - 560024, Karnataka
  • G. R. Shivaprasad
     Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal Sciences University, Veterinary College, Hebbal, Bengaluru - 560024, Karnataka

DOI:

https://doi.org/10.18311/ti/2022/v29i3/30342

Keywords:

Arsenic, Redox home ostasis, Neuropharmacology, Nano curcumin, Wistar rats

Abstract

The present study was carried out to examine the ameliorative potential of nanocurcumin against arsenic induced (sub-chronic) alterations in central nervous system in male Wistar rats. Nanocurcumin was synthesised and the hydrodynamic diameter, zeta potential and particle size were~76.60 nm, (-) 30 mV and 95nm, respectively. Experimental rats sub-chronically exposed to sodium (meta) arsenite (As; 10 mg.kg-1; 70 days; p.o) induced significant (p<0.05) reduction in superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione and favoured free radical generation and induced lipid peroxidation in brain tissue. The exposure resulted in significant (p<0.05) decrease in voluntary- and involuntary motor activities and enhanced anxiety levels. However, experimental rats receiving nanocurcumin (15 mg.kg-1; p.o) showed significant (p<0.05) recovery in enzymatic - and non-enzymatic antioxidant defence system and restoration of redox balance and overcome arsenic induced depression in motor activities and elevated anxiety levels. Further, Arsenic induced elevation in pro-inflammatory cytokines, cyclooxygenase-2 activity and prostaglandin-E2 in brain and angiotensin-II levels (plasma) was significantly (p<0.05) ameliorated by nanocurcumin. Additionally, quantitative real -time polymerase chain reaction revealed a fivefold decrease in Nox2 expression in brain following nanocurcumin administration. Thus, the study concludes that nanocurcumin can serve as a potential therapeutic candidate to counter arsenic induced redox imbalance and neuropharmacological disturbances and there exists a vast scope to exploit its utility after appropriate clinical modelling.

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2022-12-12

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Nithyashree, N., Prakash, N., Waghe, P., Santhosh, C. R., Pavithra, B. H., Rajashekaraiah, R., Sathyanarayana, M. L., Sunilchandra, U., Anjan Kumar, K. R., Manjunatha, S. S., Muralidhar, Y., & Shivaprasad, G. R. (2022). Nanocurcumin Restores Arsenic-Induced Disturbances in Neuropharmacological Activities in Wistar Rats. Toxicology International, 29(3), 429–445. https://doi.org/10.18311/ti/2022/v29i3/30342

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Volume 29, Issue 3, September 2022

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