Nanocurcumin Restores Arsenic-Induced Disturbances in Neuropharmacological Activities in Wistar Rats

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  • Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal Sciences University, Veterinary College, Hebbal, Bengaluru - 560024, Karnataka ,IN
  • Veterinary College, Vinobanagar, Shivamogga – 577204, Karnataka ,IN
  • Department of Veterinary Pharmacology and Toxicology, Veterinary College, Bidar – 585226, Karnataka ,IN
  • Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal Sciences University, Veterinary College, Hebbal, Bengaluru - 560024, Karnataka ,IN
  • Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal Sciences University, Veterinary College, Hebbal, Bengaluru - 560024, Karnataka ,IN
  • Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal Sciences University, Veterinary College, Hebbal, Bengaluru - 560024, Karnataka ,IN
  • Department of Veterinary Pathology, Veterinary College, Hebbal, Bengaluru – 560024, Karnataka ,IN
  • Department of Veterinary Pharmacology and Toxicology, Veterinary College, Vinobanagar, Shivamogga – 577204, Karnataka ,IN
  • Department of Veterinary Pathology, Veterinary College, Hebbal, Bengaluru – 560024, Karnataka ,IN
  • Department of Veterinary Pathology, Veterinary College, Vinobanagar, Shivamogga – 577204, Karnataka ,IN
  • Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal Sciences University, Veterinary College, Hebbal, Bengaluru - 560024, Karnataka ,IN
  • Department of Veterinary Pharmacology and Toxicology, Karnataka Veterinary, Animal Sciences University, Veterinary College, Hebbal, Bengaluru - 560024, Karnataka ,IN



Arsenic, Redox home ostasis, Neuropharmacology, Nano curcumin, Wistar rats


The present study was carried out to examine the ameliorative potential of nanocurcumin against arsenic induced (sub-chronic) alterations in central nervous system in male Wistar rats. Nanocurcumin was synthesised and the hydrodynamic diameter, zeta potential and particle size were~76.60 nm, (-) 30 mV and 95nm, respectively. Experimental rats sub-chronically exposed to sodium (meta) arsenite (As; 10; 70 days; p.o) induced significant (p<0.05) reduction in superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glutathione and favoured free radical generation and induced lipid peroxidation in brain tissue. The exposure resulted in significant (p<0.05) decrease in voluntary- and involuntary motor activities and enhanced anxiety levels. However, experimental rats receiving nanocurcumin (15; p.o) showed significant (p<0.05) recovery in enzymatic - and non-enzymatic antioxidant defence system and restoration of redox balance and overcome arsenic induced depression in motor activities and elevated anxiety levels. Further, Arsenic induced elevation in pro-inflammatory cytokines, cyclooxygenase-2 activity and prostaglandin-E2 in brain and angiotensin-II levels (plasma) was significantly (p<0.05) ameliorated by nanocurcumin. Additionally, quantitative real -time polymerase chain reaction revealed a fivefold decrease in Nox2 expression in brain following nanocurcumin administration. Thus, the study concludes that nanocurcumin can serve as a potential therapeutic candidate to counter arsenic induced redox imbalance and neuropharmacological disturbances and there exists a vast scope to exploit its utility after appropriate clinical modelling.


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Nithyashree, N., Prakash, N., Waghe, P., Santhosh, C. R., Pavithra, B. H., Rajashekaraiah, R., Sathyanarayana, M. L., Sunilchandra, U., Anjan Kumar, K. R., Manjunatha, S. S., Muralidhar, Y., & Shivaprasad, G. R. (2022). Nanocurcumin Restores Arsenic-Induced Disturbances in Neuropharmacological Activities in Wistar Rats. Toxicology International, 29(3), 429–445.



Research Articles
Received 2022-05-27
Accepted 2022-06-23
Published 2022-12-12



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