Diosgenin as a Novel Therapeutic Natural Product for Various Diseases: An Overview
Authors
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Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris - 643001, Tamil Nadu ,IN
Sheik Mohammed -
Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris - 643001, Tamil Nadu ,INGaddam Narasimha Rao
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Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris - 643001, Tamil Nadu ,INChintha Narendar
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Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris - 643001, Tamil Nadu ,INJeyaram Bharathi
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Department of Pharmacology, JSS College of Pharmacy, JSS Academy of Higher Education and Research, Ooty, Nilgiris - 643001, Tamil Nadu ,INAntony Justin
DOI:
https://doi.org/10.18311/jnr/2023/30378Keywords:
Biosynthesis, Diosgenin, Phytochemical, Saponin Glycoside, Steroidal HormoneAbstract
Diosgenin (DG) is a saponin glycoside and an active constituent generally present in medicinal plants like Rhizoma polgonita, Trigonella foenum, Dioscorea villosa and Dioscorea rhizome. It is also the starting material for the biosynthesis of steroidal hormones. DG has also been reported as a multipurpose drug aiding in the treatment of various cardiovascular, neurological diseases as well as as malignancies, osteoporosis, diabetes, and atherosclerosis. The underlying mechanisms of DG contributing towards potential therapeutic ability is to suppress the expression of oncogenic genes, preventing the formation of free radicals and thereby resulting in neuroprotection etc. However, the use of DG is restricted due to its limited pharmacokinetic properties such as poor aqueous solubility, poor bioavailability, and quicker biotransformation into its metabolites. Hence, in this study we have briefed the current therapeutic approaches of DG and its derivatives alongside to its medicinal chemistry and its physicochemical, pharmacological & toxicological properties.
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Copyright (c) 2023 Antony Justin, Sheik Mohammed, Gaddam Narasimha Rao, Chintha Narendar, Devinanda P Kamath, Ashwini Prem Kumar, Jeyaram Bharathi
This work is licensed under a Creative Commons Attribution 4.0 International License.
Accepted 2023-04-24
Published 2023-06-13
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