Toxicity Studies on Amukkarac Curanam - A Siddha Poly Herbal Drug


Affiliations

  • CCRAS, Captain Srinivasa Murti Drug Research Institute for Ayurveda, Chennai, 600106, India

Abstract

Objective: The effect of Amukkarac curanam (AC), a widely used Siddha medicine was evaluated for acute and chronic toxicity in rats. Material and methods: Amukkarac is botanically equated to Withania somnifera Dunal. Acute dosages were 0.5, 1.0, 1.5, 2.0, 2.5, 3.0 and 5.0 g/kg body weight while the chronic dosage was 500 mg/kg body weight /day. All external morphological, hematological, serum parameters, histopathological, in addition to body weight and vital organ weights were recorded. Results and conclusion: During this investigation no significant mortality was observed. The results showed that AC at the given dose of 500 mg/kg body weight did not produce any significant toxic effect in rats during 90 days period of the treatment.

Keywords

Chronic Toxicity, Hematology, Marker Enzymes, Lipid Profile.

Subject Discipline

Pharmacy and Pharmacology

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