Evaluation of Analgesic Activity of Eremostachys laciniata in Mice


Affiliations

  • Tabriz University of Medical Sciences, School of Pharmacy, Drug Applied Research Center, Tabriz, Iran, Islamic Republic of
  • Tabriz University of Medical Sciences, Tabriz, Iran, Islamic Republic of
  • University of Wolverhampton, School of Applied Sciences, Department of Pharmacy, Wolverhampto, England, WV11SB, United Kingdom
  • Kermanshah University of Medical Sciences, Department of Pharmacognosy, Faculty of Pharmacy, Kermanshah, Iran, Islamic Republic of
  • Tabriz University of Medical Sciences, Research Center for Pharmaceutical Nanotechnology, Tabriz, Iran, Islamic Republic of
  • University of Wolverhampton, School of Applied Sciences, Department of Pharmacy, Wolverhampton, England, WV11AD, United Kingdom

Abstract

Eremostachys laciniata (L.) Bunge (family: Lamiaceae) is one of the fifteen endemic Iranian herbs of the genus Eremostachys, and also grows in other central and western Asian countries. In the Iranian traditional medicine, this plant has been used as a local analgesic and as an anti-inflammatory remedy. In the present study, the methanol (MeOH) extract of the rhizomes of E. laciniata as well as the solid-phase extraction (SPE) fractions have been evaluated for their analgesic property in mice using the hot-plate test. All doses of the SPE 20% aq. MeOH fraction (P < 0.01) and the MeOH extract at the doses of 0.5 mg/kg (P < 0.01) and 1 mg/kg (P<0.05) displayed considerable analgesic effects. The analgesic effect of the SPE 20% aq. MeOH fraction (2.5 mg/kg) was more potent than that of the positive control, morphine (9 mg/kg) at 45 min after injection (P<0.001). However, SPE 40% aq. MeOH fraction did not show any analgesic effects at test doses.

Keywords

Eremostachys Laciniata, Lamiaceae, Analgesic, Morphine, Mice, Hot-plate Test

Subject Discipline

Pharmacy and Pharmacology

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