Effect of Piperine in Obesity Induced Insulin Resistance and Type_II Diabetes Mellitus in Rats


  • K. B. Raval College of Pharmacology, Department of Pharmacology, Gandhinagar, Gujarat, 382023, India
  • K. B. Institute of Pharmaceutical Education and Research, Department of Pharmacology, Gandhinagar, Gujarat, 382023, India
  • Crimea State Medical University, Simferopol, Ukraine


Objective: The present study was undertaken to explore the effect of piperine in obesity induced insulin resistance and type 2 diabetes mellitus. Materials and methods: Male Sprague dawley rats were fed High fat diet (HFD) for first 8 weeks to develop obesity which induced insulin resistance and diabetes mellitus. Later on piperine (400 mg/kg) and sibutramine (5 mg/kg) were administered for 3 weeks along with the continuation of HFD to two separate groups which served as test and standard respectively. Result: Body weight, serum triglyceride and glucose levels were measured at the end of 4th, 8th (before treatment) and 11th (after treatment) week while insulin tolerance test and fat mass were measured at the end of 11th week in normal, HFD-control, test and standard groups. Conclusion: Piperine significantly reduced not only body weight, fat mass, triglyceride and glucose levels but also improved sensitivity of exogenous insulin. The above results suggest that piperine has significant anti-obesity, antidiabetic activity and also improved insulin sensitivity.


Obesity, Diabetes, Insulin, Piperine, High-Fat Diet, Sibutramine.

Subject Discipline

Pharmacy and Pharmacology

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