Comparative Evaluation of Tissue Dissolution Efficacy of Azadirachta indica Irrigant and Sodium Hypochlorite – An in vitro Study


  • Vishnu Dental College, Department of Conservative Dentistry and Endodontics, Bhimavaram, Andhra Pradesh, 534202, India
  • Vishnu Dental College, Department of Conservative Dentistry and Endodontics, Bhimavaram, Andhra Pradesh, 534202


Objectives: This study aimed to evaluate the tissue dissolution efficacy of Azadirachta indica (A. indica) irrigant and sodium hypochlorite. Materials and Methods: 40 bovine muscle tissue specimens of equal dimensions were used in the experiment. Based on tissue specimen treatment, they were divided into four test groups - 3%NaOCl (Group I), 7.5% A. indica irrigant (Group II), alternative use of 3%NaOCl and 7.5% A. indica irrigant (Group III) and control group as distilled water (Group IV). Tissue specimens were weighed before and after placing in test solutions at 2 different time intervals (30,60 minutes). Results: The results revealed that 3%NaOCl showed highest tissue dissolution followed by alternative use of 3%NaOCl. and A. indica irrigant, A. indica alone and distilled water (Group I >III>II>IV). The larger the duration of contact with irrigant better is the tissue dissolution. Conclusion: 7.5% A. indica irrigant alone does not have any tissue dissolving property but in combination it acts as a neutral solution neither increasing nor decreasing the capability of 3%NaOCl.


Azadirachta indica, NaOCl, Smear Layer, Tissue Dissolution

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