Salivary Tumour Necrosis Factor - α Key Inflammatory Mediators in Periodontal Disease


Affiliations

  • Tamilnadu Government Dental College and Hospital, Department of Periodontics and Implantology,, chennai, Tamil Nadu, 600003, India
  • Tamilnadu Government Dental College and Hospital, Department of Periodontics and Implantology, Chennai, Tamil Nadu, 600003, India

Abstract

Oral health is indispensable to overall health and oral diseases especially periodontitis is well known for its high prevalence and rapid morbidity. Function of the host immune response is the most crucial feature in periodontitis. And this is the reason for both disease progression and severity. Search for a biomarker for periodontitis has turned on researches working out in finding many newer molecules (cytokines), that can help the clinician in deciding regarding the patient’s status. This review shortly covers the multiple facets of crosstalk engaged by salivary Tumour Necrosis Factor-α key inflammatory mediators in periodontal disease.


Keywords

Genetics, Immunoregulatory Cytokines, Salivary TNF, TNF-α

Subject Discipline

Dentistry

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References

Boch JA, Wara-aswapati N, Auron PE. Interleukin 1 signal transduction: Current concepts and relevance to periodontitis. J Dent Res. 2001; 80:400-7.https://doi.org/10.1177/002 20345010800020101 PMid:11332522

Benakanakere M, Kinane DF. Innate cellular responses to the periodontal biofilm. Front oral biol. 2012; 15:41-55. https://doi.org/10.1159/000329670 PMid:22142956

Kjeldsen M, Holmstrup P, Lindemann RA, Bendtzank. Bacterial stimulated cytokine production of peripheral mononuclear cells from patients of various periodontitis categories. J periodontal. 1995; 66:139-44. https://doi.org/10.1902/jop.1995.66.2.139 PMid:7730965

Socransky SS, Haffajee AD, Cugini MA, Smith C, Kent RL Jr. Microbial complexes in sub gingival plaque. J Clin Periodontol. 1998; 25:134-44.https://doi.org/10.1111/j.1600-051X.1998.tb02419.x PMid:9495612

Zambon JJ. Periodontal diseases: Microbial factors. Ann periodontal. 1996; 1:879-925. https://doi.org/10.1902/annals.1996.1.1.879 PMid:9118283

Coley WB. Contribution to knowledge of sarcoma. Ann Surg. 1891; 14:199-220. https://doi.org/10.1097/00000658189112000-00015 PMid:17859590 PMCid:PMC1428624

Lartz M, Bjornberg F, Olsson, Richter J. Adherence of neutrophils induces release of soluble TNF receptor forms. J Immunol. 1994; 152:1362-9

Rossomondo EF, White L. A novel method for the detection of TNF in GCF. J Periodontol. 1993; 64:445-49.

Socrasky SS, Haffajee AD. The bacterial etiology of destructive periodontal disease: current concepts. J Periodontol. 1992 Apr; 63(4 suppl):322-31. https://doi.org/10.1902/jop.1992.63.4s.322

Steenport M, Khan KM, Du B, Barnhard SE, Dannenberg AJ, Falcono DJ, Matrixmetallo proteinase (MMP-1 and MMP-3) induces macrophage MMP-9. Evidence for the role of TNF alpha and cyclooxygenase-2. J Immunol.2009; 183:8119-27. https://doi.org/10.4049/jimmunol.0901925 PMid:19923455 PMCid:PMC3621723

Spiliopoulou A, et al. Association of response to TNF inhibitors in Rheumatoid arthritis with quantitative trait loci for CD40 and CD39. Annals of the rheumatic diseases. 2019; 78(8):5929-6585.https://doi.org/10.1136/annrheumdis2018-214877 PMid:31036624 PMCid:PMC6669378

Kevin J. Tracey, Stephen F, Lowry. Antonycerami Cachetin/TNF alpha in septic shock and septic adult respiratory distress syndrome. American Review of Respiratory Diseases. 1988; 138(6):1377-9. https://doi.org/10.1164/ajrccm/138.6.1377 PMid:3059894

Shimada Y, Tai H, Eudo M, Kobayashi, Akazawa K, Yamazaki K. Association of tumor necrosis factor receptor type 2 +587 gene polymorphism with severe chronic periodontitis. JCP. 2004. https://doi.org/10.1111/j.1600-051X.2004.00513.x PMid:15142217

Abraham E, et al. Efficacy and safety of monoclonal antibody to human tumor necrosis factor alpha in patients with sepsis syndrome. A randomised, controlled, double blind, multicenter clinical trail. TNF - alpha mab sepsis study group. JAMA.1995 Mar 22-29; 273(12):934-41 https://doi.org/10.1001/jama.273.12.934 PMid:7884952

Beklen A, Laine M, Venta I, Hyrkas T, Konttinem Y.T. Role of TNF alpha and its receptors in pericoronitis. J Dent Res. 2005; 84(12):1178-1182. https://doi.org/10.1177/154405910508401216 PMid:16304450

Rai MK, Deshmukh SD, Ingle AP, Gade AK. Silver nanoparticles: The powerful nano weapon against multidrug resistant bacteria. J Appl Microbiol. 2012 may; 112(5): 841-52. https://doi.org/10.1111/j.1365-2672.2012.05253.x PMid:22324439

Ng Py, Donley M, et al. Candidate salivary biomarkers associated with alveolar bone loss: Cross- sectional and in vito studies. FEMS Immunol Med Microbiol. 2007 Mar: 49(2):252-60. https://doi.org/10.1111/j.1574695X.2006.00187.x PMid:17328758 PMCid:PMC2258090


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