Carbamate Pesticide Carbaryl Induces Alterations in Antioxidant and Oxidative Stress Related Responses of Indian Buffalo (Bubalus bubalis) after Sub-Chronic Exposure


Abstract

The aim of the present work was to study the alterations of the antioxidant defenses and the overall susceptibility to oxidative stress of the Bubalus bubalis exposed to the carbamate pesticide Carbaryl at the dose rate of 1mg/kg/day for 105 consecutive days produced no observable signs of toxicity in buffalo calves. However, it produced a significant increase in the extent of lipid peroxidation (42.9%) and in the activity of anti-oxidant enzymes namely glutathione peroxidase (39.2%), glutathione reductase (45.3%), glutathione-S-transferase (29%), superoxide dismutase (65%) and catalase (34.5%).On the other hand, carbaryl administration resulted in significant decrease in the blood glutathione level (26%), an important intra-cellular component of defense against oxidative damage, which is indicative of variations in the overall anti-oxidant profile of buffalo calves induced with sub-chronic carbaryl toxicosis. Overall the current results demonstrated the susceptibility of B. Bubalis to oxidative stress induced by the exposure to Carbaryl at an environmentally realistic concentrations, exposing the animal to the risk of oxidative stress damages. The observed responses can be used as sensitive biomarkers for the detection and assessment of effects caused by Carbaryl pesticide exposure.

Keywords

Carbaryl, Oxidative Stress, Buffalo Calves, Anti-Oxidant Enzymes.

Subject Discipline

Pharmacy and Pharmacology

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