Toxic Effects of Sub-Chronic Oral Exposure of Imidacloprid on Biochemical Parameters in Buffalo Calves

Authors

  • Tsewang Dorjay Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana – 141 004, Punjab
  • Rajdeep Kaur Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana – 141 004, Punjab
  • S. P. S. Saini Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana – 141 004, Punjab
  • H. S. Sandhu Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana – 141 004, Punjab

DOI:

https://doi.org/10.18311/ti/2020/v27i3&4/22489

Keywords:

Biochemical, Buffalo Calves, Imidacloprid, Subchronic

Abstract

Imidacloprid, is a highly effective and widely used neonicotinoid insecticide for crop protection and veterinary pest control, which has gained a major market control in the past several years. The present investigation was undertaken to evaluate the toxic potential of imidacloprid in buffalo calves when administered for prolonged periods. Evaluation of various biochemical markers of hepatic, renal and muscular injury was done using standardized procedures. Oral administration of imidacloprid (@ 0.5 mg/kg/day; 90 days) in male buffalo calves, produced varying degrees of nasal discharge, lachrymal discharge, lethargy and weakness. Imidacloprid exposure caused a significant increase in the levels of plasma aspartate aminotransferase (12.3%), alanine aminotransferase (172.2%), lactate dehydrogenase (13.7%), gamma-glutamyltranspeptidase (57.5%), alkaline phosphatase (37.2%), acid phosphatase (220.0%), blood urea nitrogen (148.4%), creatinine (5.22%) and cholesterol (68.9%). However, no significant changes were observed in the enzymatic activity of creatine kinase, plasma cholinesterase as well as total protein and glucose levels.

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Published

2022-08-12

How to Cite

Dorjay, T., Kaur, R., Saini, S. P. S., & Sandhu, H. S. (2022). Toxic Effects of Sub-Chronic Oral Exposure of Imidacloprid on Biochemical Parameters in Buffalo Calves. Toxicology International, 27(3&4), 86–92. https://doi.org/10.18311/ti/2020/v27i3&4/22489

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Section

Research Articles

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