Neuropathological Studies of Chickens Following Exposure to Chlorpyrifos

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Authors

  • Departments of Veterinary Pathology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana ,IN
  • Departments of Veterinary Pathology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana ,IN
  • Departments of Veterinary Pathology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana ,IN
  • Departments of Veterinary Pathology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana ,IN
  • Pharmacology and Toxicology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana ,IN

Keywords:

Chickens, chlorpyrifos, neuropathological effects
Cytology, Cell Biology

Abstract

The objective of this study was to determine the putative neuropathological effects in young chickens after administration of a single dose of 55 mg/kg bw chlorpyrifos. The gross lesions of the nervous system comprised of congestions in the brain. Microscopic examination of brain showed mild congestion of cerebral blood vessels and mild perivascular cuffing of lymphomononuclear cells in the cerebral cortex and necrosis of the neurons. The interesting findings were the presence of cytoplasmic vacuolations of cerebral neurons and swelling of the endothelial cell of the cerebral capillaries. Cerebellum showed congestion and hemorrhages in the granular layer and necrosis of Purkinje cell. Sciatic nerve exhibited mild edema, swelling and degeneration of axons, and swelling of Schwann cells. There was a significant inhibition of plasma cholinesterase enzyme activity in chickens administered with chlorpyrifos compared to chickens of control group. The study revealed that administration of chlorpyrifos produces neuropathological lesions in chickens shortly after exposure.

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Published

2018-05-16

How to Cite

Kammon, A. M., Brar, R. S., Sodhi, S., Banga, H. S., & Sandhu, H. S. (2018). Neuropathological Studies of Chickens Following Exposure to Chlorpyrifos. Toxicology International, 17(2), 78–81. Retrieved from https://informaticsjournals.com/index.php/toxi/article/view/21182

Issue

Section

Original Research
Received 2018-05-15
Accepted 2018-05-15
Published 2018-05-16

 

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