Nootropic Activity of BacoMind, An Enriched Phytochemical Composition from Bacopa monnieri

Abstract

The objective of this study was to evaluate the nootropic activity of BacoMind^TM, an enriched phytochemical composition from Bacopa monnieri , in different learning and memory paradigms viz ., elevated plus maze, passive shock avoidance test and object recognition test. BacoMind was administered for 7 days at the dose of 40, 60 and 80 mg/kg to mice in elevated plus maze and passive shock avoidance test and 27, 40 and 54 mg/kg to rats in object recognition test. Scopolamine (0.3 mg/kg) was used to induce amnesia and piracetam (100 mg/kg) served as reference standard. In elevated plus maze test, BacoMind^TM significantly (p<0.01) increased the inflexion ratio in scopolamine treated mice. In passive shock avoidance test, BacoMind^TM significantly (p<0.001) reduced the latency to reach the shock free zone and number of mistakes in 15 min in both normal as well as scopolamine treated mice. In object recognition test, BacoMind^TM significantly (p<0.001) increased the discrimination index in both normal as well as scopolamine treated rats. Thus, the findings of the present study revealed the nootropic activity of BacoMind^TM