Cytotoxicity and Antiprotozoal Activity of Flavonoids from Three Tephrosia Species


Affiliations

  • Andhra University, Pharmacognosy and Phytochemistry Division, Department of Pharmaceutical Sciences, Visakhapatnam, Andhra Pradesh, 530003, India
  • Andhra University, College of Pharmaceutical Sciences, Visakhapatnam, Andhra Pradesh, 530003, India
  • V. V. Puram Institute of Pharmaceutical Sciences, Bangalore, Karnataka, India
  • Indian Institute of Chemical Technology, Pharmacology Division, Hyderabad, Andhra Pradesh, India

Abstract

In the present study we analyzed the cytotoxicity on RAW and HT-29 cell lines by MTT assay and antiprotozoal activity on Trypanosoma, Leishmania and Plasmodium parasites of different flavonoids isolated from three species of Tephrosia, T. calophylla, T. pulcherrima and T. pumila. Pulcherrimin exhibited toxicity towards RAW and HT-29 cell lines at low concentrations. Candidone, millettone and pongachin showed toxicity towards HT-29 cell lines at low concentrations. The isolated compounds were characterized by spectral data, including 2D NMR, 1H-1H COSY and 13C-1H COSY experiments.

Keywords

Cytotoxicity, Antiprotozoal, Flavonoids, T. calophylla, T. pulcherrima, and T. pumila.

Subject Discipline

Pharmacy and Pharmacology

Full Text:

Refbacks

  • There are currently no refbacks.