Antiprotozoal and Anthelmintic Naphthoquinones from Three Unexplored Species of Diospyros


Affiliations

  • V. V. Puram Institute of Pharmaceutical Sciences, Bangalore, 590070, India
  • Andhra University, Pharmacognosy and Phytochemistry Division, Department of Pharmaceutical Sciences, Visakhapatnam, Andhra Pradesh, 530003, India
  • Andhra University, College of Pharmaceutical Sciences, Visakhapatnam, Andhra Pradesh, 530003, India
  • Swiss Tropical Institutes, Basel, CH-4002, Switzerland

Abstract

The genus Diospyros is a rich source for napthols and naphthoquinones. During the study, we have chemically examined the roots of three unexplored species of Diospyros, D. oocarpa, D. nigresence and D. candolleana for their chemical profile and biological activities. The plant materials on conventional extractions with organic solvents and sequential chromatography yielded seven naphthoquinone derivatves, habibone [1], 8'-hydroxyisodiospyrin [2], diospyrin [3], 4-hydroxy-5-methoxy-2-naphthaldehyde [4], 5-hydroxy-4-methoxy-2-naphthaldehyde [5], 4-hydroxy-3,5-dimethoxy-2-naphthaldehyde [6], and 2-methyl anthraquinone [7]. These isolates were characterized by spectral data (2D NMR, 1H-1H COSY and 13C-1H COSY). In addition, these compounds were evaluated for their potential to inhibit parasitic protozoa belonging to the genera Trypanosoma, Leishmania and Plasmodium using in vitro antiprotozoal assay and anthelmintic activity against adult earth worms, Pheretima posthuma. The study showed that the isolates enjoy significant anthelmintic and antiprotozoal activity and supports its use in folk medicine.

Keywords

Anthelmintic, Antiprotozoal, Naphthoquinones, ,i>D. oocarpa, D. nigresence, and D. candolleana.

Subject Discipline

Pharmacy and Pharmacology

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