Anti-Convulsant Activity of Roots and Barks of Calotropis gigantea Linn.

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  • ,IN
  • ,IN
  • ,IN

DOI:

https://doi.org/10.18311/jnr/2008/305

Keywords:

Calotropis gigantea, Anti-Convulsant Activity, Maximum Electroshock (MES), Pentylenetetrazole (PTZ), Hind Limb Tonic Extension (HLTE).
Therapeutic Drug Monitoring

Abstract

Objective: Calotropis gigantea Linn. (Asclepiadaceae) a widely growing plant has been traditionally used for all kinds of fits, epilepsy, convulsions in children and paralysis complaints. The present study has been undertaken to evaluate scientifically the anti-convulsant effects of roots and barks of Calotropis gigantea Linn. using maximal electroshock seizures (MES) and Pentylenetetrazole (PTZ) induced seizure models. Methods: The effect of different extracts of roots and barks of Calotropis gigantea Linn. were evaluated for their anti-convulsant profile in MES test and PTZ test using albino Wistar rats of either sex. The ED50 dose of Phenytoin (25 mg/kg) and Diazepam (4 mg/ kg) was used for comparison. Results: The methanolic extract at 400 mg/kg (Root) and 200 mg/kg (Bark) significantly (P<0.001) inhibited the hind limb tonic extension (HLTE) induced by MES and onset of clonic convulsion induced by PTZ respectively. Conclusions: The results show that the methanolic extract of the roots and barks of Calotropis gigantea Linn. produce better anti-convulsant activity compared to other extracts. So, on the basis of the present findings it can be observed that, the methanolic extracts of barks of C. gigantea possess potential anti-convulsant activity than methanolic extracts of roots of C. Gigantea.

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Published

2008-01-01

How to Cite

Patil, K. S., Suresh Babu, A. R., & Chaturvedi, S. C. (2008). Anti-Convulsant Activity of Roots and Barks of <I>Calotropis gigantea</I> Linn. Journal of Natural Remedies, 8(1), 109–114. https://doi.org/10.18311/jnr/2008/305

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