Anti-bacterial and Anti-fungal Activities of Various Extracts of Acanthospermum hispidum DC


  • Sri Ramachandra Medical College and Research Institute, College of Pharmacy, Chennai, 600116, India
  • Madras Medical College, Department of Pharmaceutical Sciences, Chennai, 600003, India


Objective: To examine the 50% aqueous-ethanol, benzene and chloroform extracts of whole plant of Acanthospermum hispidum DC for their anti-bacterial and anti-fungal properties against a wide range of microorganisms. Method: The anti-bacterial activity was studied by agar dilution method using Muller Hinton (MH) agar media. The results were compared with standard ciprofloxacin (5 μg / disc). The anti-fungal activity of the extracts was investigated by tube dilution method using Sabouraud Dextrose Agar (SDA) medium and the results compared with standard Clotrimazole (125 μg/ml). Result: All studied extracts showed potential anti-bacterial and anti-fungal properties. The MIC (Minimum Inhibitory Concentration) was found to be 66.66 μg / ml for benzene extract and of varying range (66.66-200 μg / ml) for chloroform and 50% aqueous-ethanol extracts, with different micro-organisms. The anti-fungal property of all the studied extracts were comparable with that of standard clotrimazole. Conclusion: The present study brought to light the scientific data on the anti-infective property of the plant.


Acanthospermum hispidum, DC, Anti-Microbial Activity, Anti-bacterial Activity, Anti-Fungal Property.

Subject Discipline

Pharmacy and Pharmacology

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