A Review on the Potential Anti-inflammatory Properties of Kappaphycus alvarezii
Authors
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Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore – 641114 ,IN
Silva Shihab -
Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore – 641114 ,INAnu Jacob
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Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore – 641114 ,INJissin Mathew
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Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore – 641114 ,INAlina Ann Mathew
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Department of Biotechnology, Karunya Institute of Technology and Sciences, Coimbatore – 641114 ,INA. Shanamitha
DOI:
https://doi.org/10.18311/jnr/2023/32082Keywords:
Antioxidants, Kappaphycus alvarezii, Phytochemicals, Secondary MetabolitesAbstract
Inflammation is significant innate mechanism of immunity in our human system. It enables our body to respond to a variety of stimuli, including ischemic, traumatic, physical, chemical, and infectious impulses. A major contributor to global health challenges and a significant driver of rising health expenditures are inflammatory disorders. Naturally occurring substances as well as its chemical structural analogues with anti-inflammatory potential have been discovered in the recent years. Marine life forms have a myriad source of natural molecules that can invoke inflammation as a defense against pathophysiology of illness. Macro and microalgae have been determined to be an undiscovered resource with pro-and anti-inflammatory compounds. Natural substances found in marine species can be employed in novel interventions as treatment modalities as anti-diabetic, anti-inflammatory, anti-bacterial, anti-viral, and antioxidant capabilities. Among these substances, Kappaphycus alvarezii is one such marine red algae that can be employed therapeutically to possess biological effects that exhibit strong anti-inflammatory activity and fewer adverse effects. The expanding desire to research marine seaweeds such as Kappaphycus alvarezii and its phytochemicals has made it possible to find novel substances with the potential to be used in healthcare in the near future. This review envisages the anti-inflammatory properties of marine algae along with phytochemicals discovered in Kappaphycus alvarezii and its biological functionalities.
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Copyright (c) 2023 Silva Shihab, Anu Jacob, Jissin Mathew, Alina Ann Mathew , A. Shanamitha (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Accepted 2023-04-20
Published 2023-06-13
References
Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, et al. Inflammatory responses and inflammationassociated diseases in organs. Oncotarget. 2018; 9(6):7204–18. https://doi.org/10.18632/oncotarget.23208 DOI: https://doi.org/10.18632/oncotarget.23208
Bennett JM, Reeves G, Billman GE, Sturmberg JP. Inflammation-nature’s way to efficiently respond to all types of challenges: Implications for understanding and managing “the epidemic” of chronic diseases. Front Med. 2018; 5:316. https://doi.org/10.3389/fmed.2018.00316 DOI: https://doi.org/10.3389/fmed.2018.00316
Naqvi SAR, Sherazi TA, Hassan SU, Shahzad SA, Faheem Z. Anti-inflammatory, anti-infectious and anti-cancer potential of marine algae and sponge: A review. Eur J Inflamm. 2022; 20. https://doi.org/10.1177/20587392221075514 DOI: https://doi.org/10.1177/20587392221075514
Bi D, Lai Q, Han Q, Cai N, He H, Fang W, et al. Seleno-polymannuronate attenuates neuroinflammation by suppressing microglial and astrocytic activation. J Funct Foods. 2018; 51:113–20. https://doi.org/10.1016/j.jff.2018.10.010 DOI: https://doi.org/10.1016/j.jff.2018.10.010
Ning C, Wang HMD, Gao R, Chang YC, Hu F, Meng X, et al. Marine-derived protein kinase inhibitors for neuroinflammatory diseases. Biomed Eng Online. 2018; 17(1):1–4. https://doi.org/10.1186/s12938-018-0477-5 DOI: https://doi.org/10.1186/s12938-018-0477-5
Huang C, Zhang Z, Cui W. Marine-derived natural compounds for the treatment of Parkinson’s disease. Mar Drugs. 2019; 17(4):221. https://doi.org/10.3390/md17040221 DOI: https://doi.org/10.3390/md17040221
Barbalace MC, Malaguti M, Giusti L, Lucacchini A, Hrelia S, Angeloni C. Anti-inflammatory activities of marine algae in neurodegenerative diseases. Int J Mol Sci. 2019; 20(12):3061. https://doi.org/10.3390/ijms20123061 DOI: https://doi.org/10.3390/ijms20123061
Ismail MM, Alotaibi BS, El-Sheekh MM. Therapeutic uses of red macroalgae. Molecules. 2020; 25(19). https://doi.org/10.3390/molecules25194411 DOI: https://doi.org/10.3390/molecules25194411
Adharini RI, Setyawan AR, Jayanti AD. Comparison of nutritional composition in red and green strains of Kappaphycus alvarezii cultivated in Gorontalo Province, Indonesia. E3S Web Conf EDP Sci. 2020; 147. https://doi.org/10.1051/e3sconf/202014703029 DOI: https://doi.org/10.1051/e3sconf/202014703029
Sumayya SS, Lubaina AS, Murugan K. Enzymes associated with anti-inflammatory potentialities of purified terpenoid extracts from the selected sea weeds. Int J Ayurvedic Med. 2020; 11(3):497–505. https://doi.org/10.47552/ijam.v11i3.1573 DOI: https://doi.org/10.47552/ijam.v11i3.1573
Guiry MD. How many species of algae are there? J Phycol. 2012; 48(5):1057–63. https://doi.org/10.1111/j.1529-8817.2012.01222.x DOI: https://doi.org/10.1111/j.1529-8817.2012.01222.x
Vo TS, Ngo DH, Kim SK. Potential targets for anti-inflammatory and anti-allergic activities of marine algae: An overview. Inflamm Allergy Drug Targets. 2012; 11(2):90–101. https://doi.org/10.2174/187152812800392797 DOI: https://doi.org/10.2174/187152812800392797
Liu L, Heinrich M, Myers S, Dworjanyn SA. Towards a better understanding of medicinal uses of the brown seaweed Sargassum in Traditional Chinese Medicine: A phytochemical and pharmacological review. J Ethnopharmacol. 2012; 142(3):591–619. https://doi.org/10.1016/j.jep.2012.05.046 DOI: https://doi.org/10.1016/j.jep.2012.05.046
Blunt JW, Carroll AR, Copp BR, Davis RA, Keyzers RA, Prinsep. MR. Marine natural products. Nat Prod Rep. 2018; 35(1):8–53. https://doi.org/10.1039/C7NP00052A DOI: https://doi.org/10.1039/C7NP00052A
Hakim MM, Patel IC. A review on phytoconstituents of marine brown algae. Futur J Pharm Sci. 2020; 6(1):1–11. https://doi.org/10.1186/s43094-020-00147-6 DOI: https://doi.org/10.1186/s43094-020-00147-6
Samarakoon KW, Ko JY, Rahman SM, Lee JH, Kang MC, Kwon ON, et al. In vitro studies of antiinflammatory and anticancer activities of organic solvent extracts from cultured marine microalgae. Algae. 2013; 28(1):111–9. https://doi.org/10.4490/ algae.2013.28.1.111 DOI: https://doi.org/10.4490/algae.2013.28.1.111
Jayakumar S, Saravanane R. Biodeterioration of coastal concrete structures by Macro algae-Chaetomorpha antennina. Mater Res. 2009; 12:465–72. https://doi.org/10.1590/S1516-14392009000400015 DOI: https://doi.org/10.1590/S1516-14392009000400015
Rushdi MI, Abdel-Rahman IA, Saber H, Attia EZ, Abdelraheem WM, Madkour HA, et al. Pharmacological and natural products diversity of the brown algae genus Sargassum. RSC Adv. 2020; 10(42):24951–72. https://doi.org/10.1039/D0RA03576A DOI: https://doi.org/10.1039/D0RA03576A
Rajasulochana P, Preethy V. Glimpses on cosmetic applications using marine red algae. Int J Pharm Technol. 2015; 7:9235–42.
Ferrero-Miliani L, Nielsen OH, Andersen PS, Girardin S. Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1β generation. Clin Exp Immunol. 2007; 147(2):227–35. https://doi. org/10.1111/j.1365-2249.2006.03261.x DOI: https://doi.org/10.1111/j.1365-2249.2006.03261.x
Lawrence T, Willoughby DA, Gilroy DW. Antiinflammatory lipid mediators and insights into the resolution of inflammation. Nat Rev Immunol. 2002; 2(10):787–95. https://doi.org/10.1038/nri915 DOI: https://doi.org/10.1038/nri915
Jensen GS, Attridge VL, Beaman JL, Guthrie J, Ehmann A, Benson KF. Antioxidant and anti-inflammatory properties of an aqueous cyanophyta extract derived from Arthrospira platensis: Contribution to bioactivities by the non-phycocyanin aqueous fraction. J Med Food. 2015; 18(5):535–41. https://doi.org/10.1089/jmf.2014.0083 DOI: https://doi.org/10.1089/jmf.2014.0083
Krishnaveni J, Alarmel Mangai S, Mary Jency I. In vitro anti-inflammatory activity of blue-green algae- Geitlerinema splendidum collected from Western Ghats. Asian J Pharm Clin Res. 2018; 11(5):407–409. https://doi.org/10.22159/ajpcr.2018.v11i5.25301 DOI: https://doi.org/10.22159/ajpcr.2018.v11i5.25301
Lee JC, Hou MF, Huang HW, Chang FR, Yeh CC, Tang JY, et al. Marine algal natural products with anti-oxidative, anti-inflammatory, and anti-cancer properties. Cancer Cell Int. 2013; 13(1):1–7. https://doi.org/10.1186/1475-2867-13-55 DOI: https://doi.org/10.1186/1475-2867-13-55
Bitencourt MA, Silva H, Abílio GM, Miranda GE, Moura A, Araújo-Júnior JX de, et al. Antiinflammatory effects of methanolic extract of green algae Caulerpa mexicana in a murine model of ulcerative colitis. Rev Bras Farmacogn. 2015; 25:677–82. https://doi.org/10.1016/j.bjp.2015.10.001 DOI: https://doi.org/10.1016/j.bjp.2015.10.001
Ripol A, Cardoso C, Afonso C, Varela J, Quental- Ferreira H, Pousão-Ferreira P, et al. Composition, anti-inflammatory activity, and bioaccessibility of green seaweeds from fish pond aquaculture. Nat Prod Commun. 2018; 13(5):603–8. https://doi.org/10.1177/1934578X1801300521 DOI: https://doi.org/10.1177/1934578X1801300521
Kang JY, Luyen QH, Khan MNA, Choi JS, Choi IS, Hong YK. In vivo Anti-inflammatory, antipyretic, and analgesic activities of the aquaculturable green Seaweed codium fragile extracts in mice. J Life Sci. 2012; 22(6):852–6. https://doi.org/10.5352/JLS.2012.22.6.852 DOI: https://doi.org/10.5352/JLS.2012.22.6.852
Suh SS, Hwang J, Park M, Seo HH, Kim HS, Lee JH, et al. Anti-inflammation activities of mycosporinelike amino acids (MAAs) in response to UV radiation suggest potential anti-skin aging activity. Mar Drugs. 2014; 12(10):5174–87. https://doi.org/10.3390/md12105174 DOI: https://doi.org/10.3390/md12105174
Satyalakshmi S. Determination of biological activities of three marine algae collected from Visakhapatnam coast. Asian J Pharm Clin Res. 2017; 10(12):274–9. https://doi.org/10.22159/ajpcr.2017.v10i12.20857 DOI: https://doi.org/10.22159/ajpcr.2017.v10i12.20857
Manikandan R, Parimalanandhini D, Mahalakshmi K, Beulaja M, Arumugam M, Janarthanan S, et al. Studies on isolation, characterization of fucoidan from brown algae Turbinaria decurrens and evaluation of it’s in vivo and in vitro anti-inflammatory activities. Int J Biol Macromol. 2020; 160:1263–76. https://doi.org/10.1016/j.ijbiomac.2020.05.152 DOI: https://doi.org/10.1016/j.ijbiomac.2020.05.152
Siqueira RC, da Silva MS, de Alencar DB, Pires ADF, de Alencar NM, Pereira MG, et al. In vivo anti-inflammatory effect of a sulfated polysaccharide isolated from the marine brown algae Lobophora variegata. Pharm Biol. 2011; 49(2):167–74. https://doi.org/10.3109/13880209.2010.505605 DOI: https://doi.org/10.3109/13880209.2010.505605
Vo TS, Kim J, Wijesekara I, Kong CS, Kim SK. Potent effect of brown algae (Ishige okamurae) on suppression of allergic inflammation in human basophilic KU812F cells. Food Sci Biotechnol. 2011; 20(5):1227– 34. https://doi.org/10.1007/s10068-011-0169-4 DOI: https://doi.org/10.1007/s10068-011-0169-4
Sulaiman M, Kurup GM, Rauf AA. Anti inflammatory and antioxidant effect of sulphated polysaccharide isolated from marine algae Padina tetrastromatica from Kerala coast. J Pharm Res. 2011; 4:784–8.
Mariya V, Ravindran VS. Biomedical and Pharmacological significance of marine macro algaereview. Indian J Geo-Marine Sci. 2013; 42(5):527–37.
Boujaber N, Oumaskour K, Lakhdar F. Potential targets for anti‐Inflammatory and anticancer Activities of Marine algae Gelidium sesquipedale and Laminaria ochroleuca. Int J Adv Res. 2017; 5(1):2302–9. https://doi.org/10.21474/IJAR01/3012 DOI: https://doi.org/10.21474/IJAR01/3012
Buwono NR, Risjani Y, Arsad. S. Anti-inflammatory and analgesic activity from brown algae Sargassum polycystum. J Pharm Sci Res. 2018; 10(8):2092–6.
Dore CMPG, Alves MGDCF, Will LSEP, Costa TG, Sabry DA, de Souza Rêgo LAR, et al. A sulfated polysaccharide, fucans, isolated from brown algae Sargassum vulgare with anticoagulant, antithrombotic, antioxidant and anti-inflammatory effects. Carbohydr Polym. 2013; 91(1):467–75. https://doi.org/10.1016/j.carbpol.2012.07.075 DOI: https://doi.org/10.1016/j.carbpol.2012.07.075
Hwang JH, Oh YS, Lim SB. Anti-inflammatory activities of some brown marine algae in LPS-stimulated RAW 264.7 cells. Food Sci Biotechnol. 2014; 23(3):865–71. https://doi.org/10.1007/s10068-014-0116-2 DOI: https://doi.org/10.1007/s10068-014-0116-2
Ananthi S, Gayathri V, CHandronitha C, Lakshmisundaram R, Vasanthi HR. Free radical scavenging and anti-inflammatory potential of a marine brown alga Turbinaria Ornata (turner). Indian J Geo- Marine Sci. 2011; 40(5):664–70.
Simpi CC, Nagathan CV, Karajgi SR, Kalyane NV. Evaluation of marine brown algae Sargassum ilicifolium extract for analgesic and anti-inflammatory activity. Pharmacognosy Res. 2013; 5(3):146. https://doi.org/10.4103/0974-8490.112413 DOI: https://doi.org/10.4103/0974-8490.112413
Yoon WJ, Ham YM, Kim SS, Yoo BS, Moon JY, Baik JS, et al. Suppression of pro-inflammatory cytokines, iNOS, and COX-2 expression by brown algae Sargassum micracanthum in RAW 264.7 macrophages. Eur Asian J Biosci. 2009; 3:130–43. https://doi.org/10.5053/ejobios.2009.3.0.17 DOI: https://doi.org/10.5053/ejobios.2009.3.0.17
Álvarez-Gómez F, Korbee N, Casas-Arrojo V, Abdala-Díaz, R T, Figueroa FL. UV photoprotection, cytotoxicity and immunology capacity of red algae extracts. Molecules. 2019; 24:341. https://doi.org/10.3390/molecules24020341 DOI: https://doi.org/10.3390/molecules24020341
Coura CO, Souza RB, Rodrigues JAG, Vanderlei EDSO, de Araújo IWF, Ribeiro NA, et al. Mechanisms involved in the anti-inflammatory action of a polysulfated fraction from Gracilaria cornea in rats. PLoS One. 2015; 10(3). https://doi.org/10.1371/journal.pone.0119319 DOI: https://doi.org/10.1371/journal.pone.0119319
Abraham J, Sheeba DG, Gomathy S. Hepatoprotective and anti-inflammatory activity of marine red algae Gracillaria corticata. Biosci Discov. 2018; 9(2):232–6.
García Delgado N, Frías Vázquez AI, Cabrera Sánchez H, Soto del Valle RM, Sierra Gómez Y, Suárez Alfonso AM. Anti-inflammatory and antinociceptive activities of methanolic extract from red seaweed Dichotomaria obtusata. Brazilian J Pharm Sci. 2013; 49:65–74. https://doi.org/10.1590/S1984- 82502013000100008 DOI: https://doi.org/10.1590/S1984-82502013000100008
Alkhalaf MI. Chemical composition, antioxidant, anti-inflammatory and cytotoxic effects of Chondrus crispus species of red algae collected from the Red Sea along the shores of Jeddah city. J King Saud Univ – Sci. 2021; 33(1). https://doi.org/10.1016/j.jksus.2020.10.007 DOI: https://doi.org/10.1016/j.jksus.2020.10.007
Batista JA, Dias EG, Brito T V., Prudêncio RS, Silva RO, Ribeiro RA, et al. Polysaccharide isolated from Agardhiella ramosissima: Chemical structure and anti-inflammation activity. Carbohydr Polym. 2014; 99:59–67. https://doi.org/10.1016/j.carbpol.2013.08.071 DOI: https://doi.org/10.1016/j.carbpol.2013.08.071
Nabil-Adam A, Shreadah MA. Red algae natural products for prevention of lipopolysaccharides (LPS)- induced liver and kidney inflammation and injuries. Biosci Rep. 2021; 41(1):1–22. https://doi.org/10.1042/BSR20202022 DOI: https://doi.org/10.1042/BSR20202022
Cicinskas E, Begun MA, Tiasto VA, Belousov AS, Vikhareva V V., Mikhailova VA, et al. In vitro antitumor and immunotropic activity of carrageenans from red algae Chondrus armatus and their low‐molecular weight degradation products. J Biomed Mater Res Part A. 2020; 108(2):254–66. https://doi.org/10.1002/jbm.a.36812 DOI: https://doi.org/10.1002/jbm.a.36812
de Brito TV, Prudêncio RDS, Sales AB, Vieira Júnior FDC, Candeira SJN, Franco ÁX, et al. Antiinflammatory effect of a sulphated polysaccharide fraction extracted from the red algae Hypnea musciformis via the suppression of neutrophil migration by the nitric oxide signalling pathway. J Pharm Pharmacol. 2013; 65(5):724–33. https://doi.org/10.1111/jphp.12024 DOI: https://doi.org/10.1111/jphp.12024
Makkar F, Chakraborty K. Antidiabetic and antiinflammatory potential of sulphated polygalactans from red seaweeds Kappaphycus alvarezii and Gracilaria opuntia. Int J Food Prop. 2017; 20(6):1326– 37. https://doi.org/10.1080/10942912.2016.1209216 DOI: https://doi.org/10.1080/10942912.2016.1209216
Chatter R, Ben Othman R, Rabhi S, Kladi M, Tarhouni S, Vagias C, et al. In vivo and in vitro anti-inflammatory activity of neorogioltriol, a new diterpene extracted from the red algae Laurencia glandulifera. Mar Drugs. 2011; 9(7):1293–306. https://doi.org/10.3390/md9071293 DOI: https://doi.org/10.3390/md9071293
Robertson RC, Guihéneuf F, Bahar B, Schmid M, Stengel DB, Fitzgerald GF, et al. The anti-inflammatory effect of algae-derived lipid extracts on lipopolysaccharide (LPS)-stimulated human THP-1 macrophages. Mar Drugs. 2015; 13(8):5402–24. https://doi.org/10.3390/md13085402 DOI: https://doi.org/10.3390/md13085402
Shu MH, Appleton D, Zandi K, AbuBakar S. Antiinflammatory, gastroprotective and anti-ulcerogenic effects of red algae Gracilaria changii (Gracilariales, Rhodophyta) extract. BMC Complement Altern Med. 2013; 13(1):1–13. https://doi.org/10.1186/1472-6882-13-61 DOI: https://doi.org/10.1186/1472-6882-13-61
Chalini K, Johnson M, Adaikalaraj G, Vidyarani G, Ramakrishnan P. Anti-Inflammatory Activity of Aqueous Extracts of Gracilaria. Int J Curr Pharm Res. 2017; 9(5):17–9. https://doi.org/10.22159/ijcpr.2017v9i5.22130 DOI: https://doi.org/10.22159/ijcpr.2017v9i5.22130
Ranganayaki P, Susmitha S, Vijayaraghavan R. Study on metabolic compounds of Kappaphycus alvarezii and its in vitro analysis of anti-inflammatory activity. Int J Curr Res Acad Rev. 2014; 2(10):157–66.
Hayashi L, Reis RP. Cultivation of the red algae Kappaphycus alvarezii in Brazil and its pharmacological potential. Rev Bras Farm. 2012; 22:748–52. https://doi.org/10.1590/S0102-695X2012005000055 DOI: https://doi.org/10.1590/S0102-695X2012005000055
Holdt SL, Kraan S. Bioactive compounds in seaweed: functional food applications and legislation. J Appl Phycol. 2011; 23(3):543–97. https://doi.org/10.1007/s10811-010-9632-5 DOI: https://doi.org/10.1007/s10811-010-9632-5
Dibha AF, Wahyuningsih S, Ansori ANM, Kharisma VD, Widyananda MH, Parikesit AA, et al. Utilization of secondary metabolites in algae Kappaphycus alvarezii as a breast cancer drug with a computational method. Pharmacogn J. 2022; 14(3):536–43. https://doi.org/10.5530/pj.2022.14.68 DOI: https://doi.org/10.5530/pj.2022.14.68
Prabha V, Prakash DJ, Sudha PN. Analysis of bioactive compounds and antimicrobial activity of marine algae Kappaphycus alvarezii using three solvent extracts. Int J Pharm Sci Res. 2013; 4(1):306.
Deepika RC. Phytochemical characterization of Sargassum wighitii, Kappaphycus alvarezii and Gracilaria corticata after phycocolloid extraction. Int J Pharm Chem Biol Sci. 2017;7(3).
Sumayya SS, Murugan K. Phytochemical screening, RP-HPLC and FTIR analysis of Kappaphycus alvarezii (Doty) Doty EX PC Silva: Macro red algae. J Pharmacogn Phytochem. 2017; 6(1):325–30.
Daisy A, Indra V, Geetha S, Seetharaman S, Selvamuthu B. Phytochemical profiling and antibacterial activity of seaweeds collected from pulicate lake, coramandal coast of south india. World J Pharm Pharm Sci. 2016; 5:740–55.
Kiruba NJM, Pradeep MA, Juliana SJB. 2015. Study of phytoconstituents and antibacterial activity of Kappaphycus alvarezii. Int J Curr Microbiol Appl Sci. 2015; 4:1209–17.
Seetharaman S, Indra V, Selva Muthu B, Daisy A, Geetha S. Phytochemical profiling and antibacterial potential of Kappaphycus alvarezii methanol extract against clinical isolated bacteria. World J Pharm Pharm Sci. 2016; 5(86):1328–37.
Makkar F, Chakraborty K. Antioxidant and antiinflammatory oxygenated meroterpenoids from the thalli of red seaweed Kappaphycus alvarezii. Med Chem Res. 2018; 27(8):2016–26. https://doi.org/10.1007/s00044-018-2210-0 DOI: https://doi.org/10.1007/s00044-018-2210-0
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