Indigenous Medicinal Plants Based Remedies in Management of Arthritis by Irula Tribals of Tamil Nadu – A Comprehensive Review
Authors
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Division of Biotechnology, School of Agricultural Sciences, Karunya Insitute of Technology and Sciences, Coimbatore – 641114, Tamil Nadu ,IN
S. Kavinila -
Department of Food Science and Technology, School of Life Science, Pondicherry University, Kalapet – 605014, Puducherry ,INA. Annamalai
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Division of Biotechnology and Biochemical Engineering, J.C.T. College of Engineering and Technology, Pichanur, Coimbatore – 641105, Tamil Nadu ,INP. Muthusamy
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Division of Biotechnology, School of Agricultural Sciences, Karunya Insitute of Technology and Sciences, Coimbatore – 641114, Tamil Nadu ,INR. S. David Paul Raj
DOI:
https://doi.org/10.18311/jnr/2024/35213Keywords:
Anti-inflammatory, Arthritis, Fabaceae, Painkiller, Phytochemicals,TherapiesAbstract
Arthritis is a chronic autoimmune illness that causes joint dysfunction, and antibodies directed against self-neoepitopes. Globally more than 350 million peoples have arthritis and it is the second most rheumatological problem with a prevalence of 22% to 39% in India reported by World Health Organization. Considering the numerous synthetic therapeutic strategies that target immune cells and cytokines but drug administration of allopathic anti-arthritic medicaments is still difficult because of the persistent hazardous consequences. Presently, the use of medicinal plants as a trustworthy source of new therapy has become more popular due to the numerous side effects of synthetic drugs. One of the most significant foes in modern medicine, non steroidal anti-inflammatory drugs creates huge impact on human health, high influence on living quality and has significant economic implications. National Biopharma Mission primarily focus on the development of Bio-Therapeutics to achieve the sustainable health. According to the estimations based on various literatures, Fabaceae is the most significant herbal family which includes a vast range of plants having biological and therapeutic uses. This study presents the extensive knowledge about arthritis, immunomodulatory mechanism and existing drugs and therapies. The analgesic activity, potential active chemicals from the Fabaceae genus, as well as potential mechanisms of action for these plants are studied. The scientific information and evidences presented in this review paper is crucial for determining the precise effects of Fabaceae plants on pain modulation especially for arthritic pain and anti-inflammatory properties. This could be used to separate potentially active compounds from some of these medicinal plants in the future and create synthetic therapeutics.
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Copyright (c) 2024 S. Kavinila, A. Annamalai, P. Muthusamy, R. S. David Paul Raj (Author)
This work is licensed under a Creative Commons Attribution 4.0 International License.
Accepted 2024-05-22
Published 2024-07-31
References
Basbaum AI, Bautista DM, Scherrer G, Julius D. Cellular and molecular mechanisms of pain. Cell. 2009; 139(2):267-84. https://doi.org/10.1016/j.cell.2009.09.028 PMid:19837031 PMCid:PMC2852643
Ameenudeen S, Kashif M, Banerjee S, Srinivasan H, Pandurangan AK, Waseem M. Cellular and molecular machinery of neuropathic pain: An emerging insight. Curr Pharmacol Reports. 2022; 8(4):227-35. https://doi.org/10.1007/s40495-022-00294-9 PMid:35646513 PMCid:PMC9125010
El-Tallawy SN, Nalamasu R, Salem GI, LeQuang JAK, Pergolizzi J V., Christo PJ. Management of musculoskeletal pain: An update with emphasis on chronic musculoskeletal pain. Pain Ther. 2021; 10(1):181-209. https://doi.org/10.1007/s40122-021-00235-2 PMid:33575952 PMCid:PMC8119532
Patel D, Deshmukh P. Herbal medicine − A natural cure to arthritis anti-neoplastic effects of Garcinol view project; 2013. https://www.researchgate.net/publication/274076263
Guo Q, Wang Y, Xu D, Nossent J, Pavlos NJ, Xu J. Rheumatoid arthritis: Pathological mechanisms and modern pharmacologic therapies. Bone Res. 2018; 6(1). https://doi.org/10.1038/s41413-018-0016-9 PMid:29736302 PMCid:PMC5920070
Hunter DJ, Bierma-Zeinstra S. Osteoarthritis. Lancet. 2019; 393(10182):1745-59. https://doi.org/10.1016/S0140-6736(19)30417-9 PMid:31034380
Sara BB, Sailaja AK. A review on polyherbal formulations used in the treatment of autoimmune disease like rheumatoid arthritis. J Herb Sci. 2019; 8(1):11-16.
Casale R, Symeonidou Z, Bartolo M. Topical treatments for localized neuropathic pain. Curr Pain Headache Rep. 2017; 21(3). https://doi.org/10.1007/s11916-017-0615-y PMid:28271334 PMCid:PMC5340828
Usman M, Khan WR, Yousaf N, Akram S, Murtaza G, Kudus KA, et al. Exploring the phytochemicals and anticancer potential of the members of Fabaceae family: A comprehensive review. Molecules. 2022; 27(12). https://doi.org/10.3390/molecules27123863 PMid:35744986 PMCid:PMC9230627
Wanda GJMK, Gamo FZ, Njamen D. Medicinal plants of the family of fabaceae used to treat various ailments. Fabaceae Classif Nutr Compos Heal Benefits. 2015; (January):1-19.
Figus FA, Piga M, Azzolin I, McConnell R, Iagnocco A. Rheumatoid arthritis: Extra-articular manifestations and comorbidities. Autoimmun Rev. 2021; 20(4):102776. https://doi.org/10.1016/j.autrev.2021.102776 PMid:33609792
Stavropoulos PG, Soura E, Kanelleas A, Katsambas A, Antoniou C. Reactive arthritis. J Eur Acad Dermatology Venereol. 2015; 29(3):415-24. https://doi.org/10.1111/jdv.12741 PMid:25199646
Weiss JE, Luca NJC, Boneparth A, Stinson J. Assessment and management of pain in juvenile idiopathic arthritis. Pediatr Drugs. 2014; 16(6):473-81. https://doi.org/10.1007/s40272-014-0094-0 PMid:25331986
Ragab G, Elshahaly M, Bardin T. Gout: An old disease in new perspective - A review. J Adv Res. 2017; 8(5):495-511. https://doi.org/10.1016/j.jare.2017.04.008 PMid:28748116 PMCid:PMC5512152
McKeon KP, Jiang SH. Treatment of systemic lupus erythematosus. Aust Prescr. 2020; 43(3):85-90. https://doi.org/10.18773/austprescr.2020.022 PMid:32675909 PMCid:PMC7358053
Finckh A, Gilbert B, Hodkinson B, Bae S-C, Thomas R, Deane KD, et al. Global epidemiology of rheumatoid arthritis. Nat Rev Rheumatol. 2022; 18:591-602. https://doi.org/10.1038/s41584-022-00827-y PMid:36068354
Scherer HU, Häupl T, Burmester GR. The etiology of rheumatoid arthritis. J Autoimmun. 2020; 110:102400. https://doi.org/10.1016/j.jaut.2019.102400 PMid:31980337
Iqbal J, Zaidi M. Understanding estrogen action during menopause. Endocrin. 2009; 150(8):3443-45. https://doi.org/10.1210/en.2009-0449 PMid:19622779 PMCid:PMC2717878
Petrelli F, Mariani FM, Alunno A, Puxeddu I. Pathogenesis of rheumatoid arthritis: One year in review 2022. Pathog Rheum Arthritis One Year Rev 2022. 2022; 40(3):475-82. https://doi.org/10.55563/clinexprheumatol/l9lyen PMid:35333708
Singh S, Singh TG, Mahajan K, Dhiman S. Medicinal plants used against various inflammatory biomarkers for the management of rheumatoid arthritis. J Pharm Pharmacol. 2020; 72(10):1306-27. https://doi.org/10.1111/jphp.13326 PMid:32812250
Aviña-Zubieta JA, Choi HK, Sadatsafavi M, Etminan M, Esdaile JM, Lacaille D. Risk of cardiovascular mortality in patients with rheumatoid arthritis: A meta-analysis of observational studies. Arthritis Rheum. 2008; 59(12):1690-7. PMid:19035419
Handa R, Rao URK, Lewis JFM, Rambhad G, Shiff S, Ghia CJ. Literature review of rheumatoid arthritis in India. Int J Rheum Dis. 2016; 19(5):440-51. https://doi.org/10.1111/1756-185X.12621 PMid:26171649
Choudhary M, Kumar V, Malhotra H, Singh S. Medicinal plants with potential anti-arthritic activity: J Intercult Ethnopharmacol. 2015; 4(2):147. https://doi.org/10.5455/jice.20150313021918 PMid:26401403 PMCid:PMC4566784
Chunxia C, Peng Z, Huifang P, Hanli R, Zehua H, Jizhou W. Extracts of Arisaema rhizomatum C.E.C. Fischer attenuate inflammatory response on collagen-induced arthritis in BALB/c mice. J Ethnopharmacol. 2011; 133(2):573-82. https://doi.org/10.1016/j.jep.2010.10.035 PMid:21029771
Choy EHS, Panayi GS. Cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med. 2001; 344(12):907-16. https://doi.org/10.1056/NEJM200103223441207 PMid:11259725
Mateen S, Zafar A, Moin S, Khan AQ, Zubair S. Understanding the role of cytokines in the pathogenesis of rheumatoid arthritis. Clin Chim Acta. 2016; 455:161-71. https://doi.org/10.1016/j.cca.2016.02.010 PMid:26883280
Jeong JW, Lee HH, Lee KW, Kim KY, Kim SG, Hong SH, et al. Mori folium inhibits interleukin-1β-induced expression of matrix metalloproteinases and inflammatory mediators by suppressing the activation of NF-κB and p38 MAPK in SW1353 human chondrocytes. Int J Mol Med. 2016; 37(2):452-60. https://doi.org/10.3892/ijmm.2015.2443 PMid:26707272
Asif Amin M, Fox DA, Ruth JH. Synovial cellular and molecular markers in rheumatoid arthritis. Semin Immunopathol. 2017; 39(4):385-93. https://doi.org/10.1007/s00281-017-0631-3 PMid:28497350 PMCid:PMC5521018
Araki Y, Mimura T. The mechanisms underlying chronic inflammation in rheumatoid arthritis from the perspective of the epigenetic landscape. J Immunol Res. 2016; 2016:1-10. https://doi.org/10.1155/2016/6290682 PMid:28116320 PMCid:PMC5225373
Kinne RW, Bräuer R, Stuhlmüller B, Palombo-Kinne E, Burmester GR. Macrophages in rheumatoid arthritis. Arthritis Research. Arthritis Res. 2000; 2(3):189. https://doi.org/10.1186/ar86 PMid:11094428 PMCid:PMC130001
Nevius E, Gomes AC, Pereira JP. Inflammatory cell migration in rheumatoid arthritis: A comprehensive review. Clin Rev Allergy Immunol. 2016; 51(1):59-78. https://doi.org/10.1007/s12016-015-8520-9 PMid:26511861 PMCid:PMC5785098
Yap HY, Tee S, Wong M, Chow SK, Peh SC, Teow SY. Pathogenic role of immune cells in rheumatoid arthritis: Implications in clinical treatment and biomarker development. Cells. 2018; 7(10):161. https://doi.org/10.3390/cells7100161 PMid:30304822 PMCid:PMC6211121
Papadaki M, Rinotas V, Violitzi F, Thireo T, Panayotu G, Samiotaki M, et al. New insights for RANKL as a proinflammatory modulator in modeled inflammatory arthritis. Front Immunol. 2019; 10. https://doi.org/10.3389/fimmu.2019.00097 PMid:30804932 PMCid:PMC6370657
Shcherbatenko SI. Treatment for rheumatoid arthritis. Kazan Med J. 2021; 43(5):53-5. https://doi.org/10.17816/kazmj87788
Badiu C. Harrison’s principles of internal medicine 16th ed. Acta Endocrinol. 2005; 1(4):499. https://doi.org/10.4183/ aeb.2005.499
Mazumder PM, Mondal A, Sasmal D, Arulmozhi S, Rathinavelusamy P. Evaluation of antiarthritic and immunomodulatory activity of Barleria lupulina. Asian Pac J Trop Biomed. 2012; 2(3):S1400-6. https://doi.org/10.1016/S2221-1691(12)60425-0
Keystone E, van der Heijde D, Mason D, Landewe R, van Vollenhoven R, Combe B, et al. Certolizumab pegol plus methotrexate is significantly more effective than placebo plus methotrexate in active rheumatoid arthritis: Findings of a fifty-two-week, phase III, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Arthritis Rheum. 2008; 58(11):3319-29. https://doi.org/10.1002/art.23964 PMid:18975346
Kostoglou-Athanassiou I, Athanassiou P, Lyraki A, Raftakis I, Antoniadis C. Vitamin D and rheumatoid arthritis. Ther Adv Endocrinol Metab. 2012; 3(6):181-7. https://doi.org/10.1177/2042018812471070 PMid:23323190 PMCid:PMC3539179
Dubey GP. Herbs used in Siddha Medicine for arthritis-A review evaluation of heavy metal in 500 plants and pesticides residue in 300 plants under the sponsorship of Ayurvedic Pharmacopoeia Committee (APC) scheme view project Eugene Wilson central council for resear; 2007. https://www.researchgate.net/publication/237278253
Kadhim MJ, Kaizal AF, Hameed IH. Medicinal plants used for treatment of rheumatoid arthritis: A review. Int J Pharm Clin. 2016; 8(12); 1685-94.
Sharma K, Sahoo J, Sahu D, Chattopadhyay A, Kumar S, Mishra S. Therapeutic evaluation of Ayush Tulsi Jiwan Plus oil for chronic musculoskeletal pain relief. AYU 2015; 36(4):387-96. https://doi.org/10.4103/0974-8520.190687 PMid:27833366 PMCid:PMC5041386
Rawat N, Aggarwal V, Roushan R. Ayurvedic treatment of rheumatoid arthritis: A case study. Int J Res Ayurveda Pharm. 2021; 12(1):1-4. https://doi.org/10.7897/2277-4343.12011
Rahman MS, Mujahid M, Siddiqui MA, Rahman AM, Arif M, Eram S, et al. Ethnobotanical uses, phytochemistry and pharmacological activities of Pterocarpus marsupium: A review. Pharmacogn J. 2018; 10(6):S1-8. https://doi.org/10.5530/pj.2018.6s.1
Boddupally M, Rani SS, Thirupathi AT, Rao K, Vasanthi R. In vitro anti-arthritic effect of the leaves of Cassia fistula Linn. Eur J Pharm Med Res. 2017; 4(2):522-4.
Jain NK, Chhajed M. Effect of flavonoid fraction of Butea monosperma on rheumatoid arthritis: An in vivo study. Int J Pharm Clin. 2020.
Booth NL, Piersen CE, Banuvar S, Geller SE, Shulman LP, Farnsworth NR. Clinical studies of red clover (Trifolium pratense) dietary supplements in menopause: A literature review. Menopause. 2006; 13(2):251-64. https://doi.org/10.1097/01.gme.0000198297.40269.f7 PMid:16645539
Stohs SJ, Bagchi D. Antioxidant, anti-inflammatory, and chemoprotective properties of Acacia catechu heartwood extracts. Phyther Res. 2015; 29(6):818-24. https://doi.org/10.1002/ptr.5335 PMid:25802170 PMCid:PMC6680240
Al Muqarrabun LMR, Ahmat N, Ruzaina SAS, Ismail NH, Sahidin I. Medicinal uses, phytochemistry and pharmacology of Pongamia pinnata (L.) Pierre: A review. J Ethnopharmacol. 2013; 150(2):395-420. https://doi.org/10.1016/j.jep.2013.08.041 PMid:24016802
Lyß G, Knorre A, Schmidt TJ, Pahl HL, Merfort I. The antiinflammatory sesquiterpene Lactone Helenalin inhibits the transcription factor NF-κB by directly Targeting p65. J Biol Chem. 1998; 273(50):33508-16. https://doi.org/10.1074/jbc.273.50.33508 PMid:9837931
Bharti R, Chopra BS, Raut S, Khatri N. Pueraria tuberosa: A review on traditional uses, Pharmacology, and phytochemistry. Front Pharmacol. 2021; 11. https://doi.org/10.3389/fphar.2020.582506 PMid:33708108 PMCid:PMC7941752
Rather LJ, Shahid-ul-Islam, Mohammad F. Acacia nilotica (L.): A review of its traditional uses, phytochemistry, and pharmacology. Sustain Chem Pharm. 2015; 2:12-30. https://doi.org/10.1016/j.scp.2015.08.002
Prabhu S, Vijayakumar S, Ramasubbu R, Praseetha PK, Karthikeyan K, Thiyagarajan G, et al. Traditional uses, phytochemistry and pharmacology of Bauhinia racemosa Lam.: A comprehensive review. Futur J Pharm Sci. 2021; 7(1). https://doi.org/10.1186/s43094-021-00251-1
Oyebanji BO, Saba AB, Oridupa OA. Anti-nociceptive and anti-inflammatory activities of methanol extract of the leaves of Cajanus cajan. Niger J Physiol Sci. 2014; 29(2014):183-8.
Al-Snafi PDAE. The pharmacology and medical importance of Dolichos lablab (Lablab purpureus) - A review. IOSR J Pharm. 2017; 7(2):22-30. https://doi.org/10.9790/3013-0702012230
Nanjwade BK. Anti-inflammatory and anti-arthritic activity of Sesbania grandiflora and Sesbania sesban Bark in Rats. Adv Pharmacol Toxicol. 2011; 12(1):61-70.
Akhitha N, Raghavendra M, Venkata M, Kumar K. Protective effect of Bauhinia tomentosa L. extract against gentamicin induced nephrotoxicity in Wistar male Albino rats. Int J Pharm Sci Res. 2019; 10(3):1412-19. https://doi.org/10.13040/IJPSR.0975-8232.10(3).1412-19
Kaushal A, Vishwavidyalaya GK, Sharma M, Vishwavidyalaya GK, Vishwavidyalaya GK, Sharma M. Ethnomedicinal, phytochemical, therapeutic and pharmacological review of the genus Erythrina. Int J Botany Stud. 2020; 5(6):642-8.
Ntshanka NM, Ejidike IP, Mthunzi FM, Moloto MJ, Mubiayi KP. Investigation into the phytochemical profile, antioxidant and antibacterial potentials of Combretum molle and Acacia mearnsii leaf parts. Biomed Pharmacol J. 2020; 13(4):1683-94. https://doi.org/10.13005/bpj/2043
Veronica SA, Cheruiyot KS, Bosibori MJ, Munene IM, Murugi NJ, Piero NM. Antiinflammatory, analgesic and antipyretic effects of dichloromethane stem bark extract of Acacia mellifera. 2017; 6(4):239-46. https://doi.org/10.31254/phyto.2017.6407
Magnini RD, Hilou A, Millogo-Koné H, Compaore S, Pagès J-M, Davin-Regli A. A review on ethnobotanical uses, biological activities and phytochemical aspects of Acacia senegal (L.) Willd. and Acacia seyal Delile. (Fabaceae). Int J Plant Sci Hortic. 2020:32-55. https://doi.org/10.36811/ijpsh.2020.110023
Umashankar DD. Plant secondary metabolites as regenerative medicine. J Phytopharm. 2020; 9(4):270-3. https://doi.org/10.31254/phyto.2020.9410
Tippani R, Porika M, Allenki V, Anreddy RNR, Yellu NR, Krishna DR, et al. Antioxidant and analgesic activities of Pterocarpus marsupium Roxb. J Herbs, Spices Med Plants. 2010; 16(1):63-8. https://doi.org/10.1080/10496475.2010.481942
Pant DR, Pant ND, Saru DB, Yadav UN, Khanal DP. Phytochemical screening and study of antioxidant, antimicrobial, antidiabetic, anti-inflammatory and analgesic activities of extracts from stem wood of Pterocarpus marsupium Roxburgh. J Intercult Ethnopharmacol. 2017; 6(2):170-6. https://doi.org/10.5455/jice.20170403094055 PMid:28512598 PMCid:PMC5429076
Rahman MS, Mujahid MM, Siddiqui MA, et al. Ethnobotanical uses, phytochemistry and pharmacological activities of Pterocarpus marsupium: A review. Pharmacogn J. 2018; 10(6s):s1-8. https://doi.org/10.5530/pj.2018.6s.1
Saeed M, Naseer S, Hussain S, Iqbal M. Phytochemical composition and pharmacological effects of Cassia fistula. Sci Inq Rev. 2020; 4(1):59-69. https://doi.org/10.32350/sir.41.05
Maqsood A, Munir A, Shahid S. A phytopharmacological evaluation of Cassia fistula. A comprehensive review. Int J Pharm Sci Rev Res. 2020; 62(2):45-53.
Farooq H, Piracha MI, Alam SS. Prophylactic anti-arthritic effect of Cassia fistula in murine rheumatoid arthritis model. Proc Shaikh Zayed Medic Compl Lahore. 2019; 32:667-99.
Wankhade MS, Mulani R. Preliminary phytochemical screening and chromatographic fingerprint analysis of Acacia leucopholea Roxb. methanolic leaf. 2015.
Win T. A study of phytochemical constituents and colouring matter from the bark of Acacia Leucophloea Willd. (Hta-Naun). Yadanabon University Res J. 2018; 9(1):1-6.
Thooyavan G, Karthikeyan J. Phytochemical profiling and GC-MS analysis of Butea monosperma seed methanol extract. J Pharmacogn Phytochem. 2016; 5(5):152-7.
Pandey Rani Durgavati Vishwavidyalaya P, Garg Rani Durgavati Vishwavidyalaya A, Kumar Shukla A, Pandey P, Garg A, Shukla A, et al. Preliminary phytochemical and physicochemical investigation and thin layer chromatography of Butea monosperma flower extract [Internet]. Journal of Medical Pharmaceutical and Allied Sciences. 2016. Available from: www.jmpas.com
Ahmad S, Zeb A. Phytochemical profile and pharmacological properties of Trifolium repens. J Basic Clin Physiol Pharmacol. 2021; 32(1). https://doi.org/10.1515/jbcpp-2020-0015 PMid:32776902
Antonescu AI, Miere F, Fritea L, Ganea M, Zdrinca M, Dobjanschi L, et al. Perspectives on the combined effects of Ocimum basilicum and Trifolium pratense extracts in terms of phytochemical profile and pharmacological effects. Plants. 2021; 10(7):1390. https://doi.org/10.3390/plants10071390 PMid:34371593 PMCid:PMC8309466
Thakur AV, Ambwani S, Ambwani T. Preliminary phytochemical screening and GC-MS analysis of leaf extract of Acacia catechu (L.f.) Willd. Int J Herb Med. 2018; 6(2):81-5.
Adhikari B, Aryal B, Bhattarai BR. A comprehensive review on the chemical composition and pharmacological activities of Acacia catechu (L.f.) Willd. J Chem. 2021; 2021. https://doi.org/10.1155/2021/2575598
Baranitharan M, Alarifi S, Alkahtani S, Ali D, Elumalai K, Pandiyan J, Krishnappa K, et al. Phytochemical analysis and fabrication of silver nanoparticles using Acacia catechu: An efficacious and ecofriendly control tool against selected polyphagous insect pests. Saudi J Biol Sci. 2021; 28(1):148-56. https://doi.org/10.1016/j.sjbs.2020.09.024 PMid:33424291 PMCid:PMC7785431
Deepthi VJ. Karanja leaf - A pharmacognostical and phytochemical analysis. J Pharm Phyto. 2016; 5(5):148-51.
Yadav RD, Jain S, Alok S, Prajapati S, Verma A. Pongamia pinnata: An overview. J Chem Inf Model. 2013; 53(3):1689-99.
Yadav RD, Jain SK, Alok S, Kailasiya D, Kanaujia VK, Kaur S. A study on phytochemical investigation of Pongamia pinnata Linn. leaves. Int J Pharm Sci Res. 2011; 2(8):2073-9.
Pastorino G, Cornara L, Soares S, Rodrigues F, Oliveira MBPP. Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review. Phyther Res. 2018; 32(12):2323-39. https://doi.org/10.1002/ptr.6178 PMid:30117204 PMCid:PMC7167772
Al-Snafi AE. Glycyrrhiza glabra: A phytochemical and pharmacological review. IOSR J Pharm. 2018; 8(6):1-17.
Hasan MK, Ara I, Mondal MSA, Kabir Y. Phytochemistry, pharmacological activity, and potential health benefits of Glycyrrhiza glabra. Heliyon. 2021; 7(6):E07240. https://doi.org/10.1016/j.heliyon.2021.e07240 PMid:34189299 PMCid:PMC8220166
Balaji RM, Shanthakumari D. Investigation on phytochemical and antimicrobial properties of Acorus calamus extract. Pal Arch’s J Archaeol Egypt/Egyptology.2020; 17(9):6744-55.
Jame R. Phytochemical and pharmacological uses of Acacia nilotica-A review. Artic Int J Biol Chem. 2019; 3(2):6-10.
Bhat PK, Byakod AS, Sushma GS. Phytochemical screening of Acacia nilotica extract: An in vitro study. Int J Community Med Public Heal. 2023; 10(4):1525-9. https://doi.org/10.18203/2394-6040.ijcmph20230935
Sharanabasappa GK, Santosh MK, Shaila D, Seetharam YN, Sanjeevarao I. Phytochemical studies on Bauhinia racemosa Lam. Bauhinia purpurea Linn. and Hardwickia binata Roxb. E-Journal Chem. 2007; 4(1):21-31. https://doi.org/10.1155/2007/874721
Fatima M, Ahmed S, Siddiqui MUA, ul Hasan MM. Medicinal uses, phytochemistry and pharmacology of Bauhinia racemosa Lam. J Pharmacogn Phytochem. 2021; 10(2):121-4. https://doi.org/10.22271/phyto.2021.v10.i2b.13972
Gerrano AS, Moalafi A, Seepe HA, Amoo S, Shimelis H. Nutritional and phytochemical compositions and their interrelationship in succulent pods of pigeonpea (Cajanus cajan [L.] Millsp.). Heliyon. 2022; 8(3). https://doi.org/10.1016/j.heliyon.2022.e09078 PMid:35284666 PMCid:PMC8914194
Verma AK, Singh S. Phytochemical analysis and in vitro cytostatic potential of ethnopharmacological important medicinal plants. Toxicol Reports. 2020; 7:443-52. https://doi.org/10.1016/j.toxrep.2020.02.016 PMid:32181145 PMCid:PMC7063129
Patil MS, Chittam KP, Patil SB. Phytochemical screening of Sesbania grandiflora L . bark. J Pharm Sci Technol. 2021; 10(4):153-8.
Moh M, Kyaw M. Investigation of phytochemical constituents and antimicrobial activities of flowers of Sesbania grandiflora (Linn) (Pauk pan phyu). Int J Innovat Res Multidiscipl Field. 2019; (5):37-43.
Mini R, Prabhu V, Vimaladevi K, Sowmiya J, Sibi G. GC-MS analysis, phytochemical screening and biological activity of Bauhinia tomentosa (Linn.). Asian J Chem. 2021; 33(11):2641-4. https://doi.org/10.14233/ajchem.2021.23363
Hussain MM. A further comprehensive review on the phytoconstituents from the genus erythrina. Bangladesh Pharm J. 2020; 23(1):65-77. https://doi.org/10.3329/bpj.v23i1.45321
Nair SS. Evaluation of anti-inflammatory activity of the plant extract Smithia sensitiva. Der Pharmacia Lettre. 2016; 8(4):310-14.
Pedro SI, Rosado T, Barroca C, Neiva D, Alonso-Herranz, Gradillas A, Garcia A, et al. Characterisation of the phenolic profile of Acacia retinodes and Acacia mearnsii flowers’ extracts. Plants. 2022; 11(11):1-17. https://doi.org/10.3390/plants11111442 PMid:35684215 PMCid:PMC9182983
Madjid O. A, Sanni A, Lagnika L. Chemical diversity and pharmacological properties of Genus Acacia. Asian J Appl Sci. 2020; 13(2):40-59. https://doi.org/10.3923/ajaps.2020.40.59
Elnour AAM, Mirghani MES, Kabbashi NA, Md Alam Z, Musa KH. Study of antioxidant and anti-inflammatory crude methanol extract and fractions of Acacia seyal Gum. Am J Pharmacol Pharmacother. 2018; 5(1):3. https://doi.org/10.21767/2393-8862.100013
Elmi A, Spina R, Risler A, Philippot S, Merito A, Duval RE, et al. Extracts and isolated compounds. Molecules. 2020; 25(2392):1-15. https://doi.org/10.3390/molecules25102392 PMid:32455580 PMCid:PMC7288156
Katiyar D, Singh Mahalwal V, Ali M. Phytochemical and pharmacological profile of Pterocarpus marsupium: A review [Internet]. 2016.
Sathasivampillai SV. Bulletin of biotechnology bioactivities of extracts and isolated compounds of Vachellia leucophloea (Roxb.). 2021; 2:16-22. https://doi.org/10.51539/biotech.948394
Avula M. In vitro and in vivo anti inflammatory activity of Butea monosperma stem bark extract. 2010; 1:44-51.
Vishali N, Kamakshi K, Suresh S, Prakash S. Red clover Trifolium pratense (Linn.) isoflavones extract on the pain threshold of normal and ovariectomized rats - a long-term study. Phyther Res. 2011; 25(1):53-58. https://doi. org/10.1002/ptr.3217 PMid:20623592
Wang X-S, Guan S-y, Liu A, Yie J, Hu L-n, Zhang K, et al. Anxiolytic effects of formononetin in an inflammatory pain mouse model. Mol Brain. 2019; 12(1):36. https://doi.org/10.1186/s13041-019-0453-4 PMid:30961625 PMCid:PMC6454770
Ghumare P, Jirekar DB, Farooqui M, Naikwade SD. A Review of Pongamia pinnata - An important medicinal plant [Internet]. Current Research in Pharmaceutical Sciences. 2014; 4. Available from: https://www.researchgate.net/publication/273374447
Bulugonda RK, Kumar KA, Gangappa D, Beeda H, Philip GH, Rao DM, et al. Mangiferin from Pueraria tuberosa reduces inflammation via inactivation of NLRP3 inflammasome. Sci Rep. 2017; 7:42683. https://doi.org/10.1038/srep42683 PMid:28218280 PMCid:PMC5316935
Sokeng S, Nkono BL, Nkono Y, Taiwe GS, Cherrah Y. Acute and chronic anti-inflammatory effects of the aqueous extract of Acacia nilotica (L.) Del. (Fabaceae) pods. Acad J Med Plants. 2013; 1(1):1-5.
Kumar KR, Divya J, Kumar YA, Rajyalakshmi G, Divya J. Evaluation of anti-inflammatory activity of Lalab purpureous methanolic leaves extract on Wister Albino rats. 2018; 2(5):74-7.
Kadhim MJ, Kaizal AF, Hameed IH. Medicinal plants used for treatment of rheumatoid arthritis: A review. Int J Pharm Clin. 2016; 8(12):1685-94.
Moore RA, Derry S, Simon LS, Emery P. Nonsteroidal anti‐inflammatory drugs, gastroprotection, and benefit-risk. Pain Pract. 2014; 14(4):378-95. https://doi.org/10.1111/papr.12100 PMid:23941628 PMCid:PMC4238833
Luchting B, Azad SC. Pain therapy for the elderly patient. Curr Opin Anaesthesiol. 2019; 32(1):86-91. https://doi.org/10.1097/ACO.0000000000000675 PMid:30520741
Boyd A, Bleakley C, Hurley DA, Gill C, Hannon-Fletcher M, Bell P, et al. Herbal medicinal products or preparations for neuropathic pain. Cochrane Database Syst Rev. 2019; 2021(5). https://doi.org/10.1002/14651858.CD010528.pub4 PMid:30938843 PMCid:PMC6445324
Jahromi B, Pirvulescu I, Candido KD, Knezevic NN. Herbal medicine for pain management: Efficacy and drug interactions. Pharmaceutics. 2021; 13(2):251. https://doi.org/10.3390/pharmaceutics13020251 PMid:33670393 PMCid:PMC7918078
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