Cadmium-induced Oxidative Stress and Evaluation of Embilica officinalis and Stressroak in Broilers

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Authors

  • G. Swapna
     Department of Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad - 30 ,IN
  • A. Gopala Reddy
     Department of Pharmacology and Toxicology, College of Veterinary Science, Rajendranagar, Hyderabad - 30 ,IN
  • A. Rajasekhar Reddy
     Department of Pharmacology and Toxicology, College of Veterinary Science, Korutla, Karimnagar (Dist), Andhra Pradesh ,IN

Keywords:

Cadmium, Emblica officinalis, oxidative stress, stressroak, vitamin E
Behavioral ecology

Abstract

Cadmium (Cd) toxicity was studied in broilers, and efficacy of Emblica officinalis (500 ppm in feed), vitamin E (300 ppm in feed), and stressroak (1 g/kg feed) were evaluated for prophylactic and therapeutic management of Cd toxicity. One-day-old male broiler chicks were randomly divided into eight groups consisting of 10 chicks in each. Groups 1 and 2 were maintained as plain control and Cd (100 ppm in feed) toxic control (for six weeks). Groups 3, 4, and 5 were maintained on a combination of Cd (100 ppm in feed) and Emblica officinalis, vitamin E, and stressroak for six weeks. Groups 6, 7, and 8 were maintained with Cd for the first four weeks and on Emblica officinalis, vitamin E, and stressroak during the subsequent two weeks without Cd. Body weights, feed consumed, Feed conversion ratio (FCR), and glulathione (GSH) were significantly (P<0.05) decreased, whereas the activities of antioxidant enzymes (catalase and Superoxide dismutase (SOD)) and concentration of Thiobarbituric acid reacting substances (TBARS) were significantly (P<0.05) increased in toxic control group. After treatment with Emblica officinalis, vitamin E, and stressroak in groups 6, 7, and 8 during last two weeks and discontinuation of Cd, the parameters revealed improvement. From this study, it is concluded that Cd induces toxicity by oxidative stress, and supplementing Emblica officinalis, vitamin E, and stressroak in feed is useful in preventing and treating the toxicity.

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Published

2018-05-16

How to Cite

Swapna, G., Reddy, A. G., & Reddy, A. R. (2018). Cadmium-induced Oxidative Stress and Evaluation of <i>Embilica officinalis</i> and Stressroak in Broilers. Toxicology International, 17(2), 49–51. Retrieved from https://informaticsjournals.com/index.php/toxi/article/view/21175

Issue

Volume 17, Issue 2, July-December 2010

Section

Original Research
Received 2018-05-15
Accepted 2018-05-15
Published 2018-05-16

 

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