Evaluation of Oxidative Stress and Genotoxicity in Battery Manufacturing Workers Occupationally Exposed to Lead

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Authors

  • Zorawar Singh
     ,IN
  • Pooja Chadha
     ,IN
  • Suman Sharma
     ,IN

Keywords:

Battery manufacturing workers, blood lead levels, buccal micronucleus test, genotoxicity, lead, lipid peroxidation, malondialdehyde

Abstract

Battery manufacturing workers are occupationally exposed to lead (Pb), which is a highly toxic heavy metal. The aim of this study was to investigate the blood lead levels (BLL) of 30 battery manufacturing workers and find the correlation between BLL, micronucleated cell (MNC) frequency, binucleated cell (BNC) frequency in buccal mucosal cells and malondialdehyde concentrations in serum. 30 subjects of the BMW group, exposed to lead, and 30 control subjects, matched with the exposed subjects with respect to age, socio"‘economic status, sex, diet, smoking and drinking habits, were monitored for this study. BLL was found to have highly significant difference between both the groups (P < 0.001). The serum MDA levels were observed at significantly higher levels (6.76 ± 3.26) for the exposed group as compared to the control group (2.10 ± 1.02; P < 0.001). Buccal micronucleus test showed that both MNC and BNC frequencies were higher among the workers, in comparison to the control subjects. A positive correlation has been found between BLL and all the parameters. Our results indicate an increased health associated risk for workers occupationally exposed to lead.

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Published

2018-08-09

How to Cite

Singh, Z., Chadha, P., & Sharma, S. (2018). Evaluation of Oxidative Stress and Genotoxicity in Battery Manufacturing Workers Occupationally Exposed to Lead. Toxicology International, 20(1), 95–100. Retrieved from https://informaticsjournals.com/index.php/toxi/article/view/21714

Issue

Volume 20, Issue 1, January - April 2013

Section

Original Research
Received 2018-08-09
Accepted 2018-08-09
Published 2018-08-09

 

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