Anti-Diabetic Activity of Herbal Remedies

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Authors

  • Dhanya B. Sen
     Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara – 391760, Gujarat ,IN
  • Ramachandran Balaraman
     Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara – 391760, Gujarat ,IN
  • Ashim Kumar Sen
     Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara – 391760, Gujarat ,IN
  • Aarti S. Zanwar
     Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara – 391760, Gujarat ,IN
  • K. P. Greeshma
     Department of Chemistry, Sri Ramakrishna College of Arts and Science (SRCAS), Coimbatore – 641006, Tamil Nadu ,IN
  • Rajesh A. Maheshwari
     Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara – 391760, Gujarat ,IN

DOI:

https://doi.org/10.18311/jnr/2023/32182

Keywords:

Anti-Diabetic, Antioxidant, India, Side Effects, Traditional Medicines

Abstract

Herbal remedies, often known as herbal medicine or botanical medicine, are natural treatments that make use of the therapeutic capabilities of plants and plant-based extracts. Due to their apparent efficacy and lack of negative side effects, these treatments have been practiced for centuries in numerous civilizations all over the world. The usage of plant parts such as leaves, stems, flowers, roots, and seeds, as well as extracts made from plants, are just a few examples of the diverse practices that fall under the umbrella of herbal medicines. Numerous consequences are linked to diabetes, a long-term metabolic illness characterized by elevated blood sugar levels that affects millions of individuals worldwide. Many cultures have a long history of using herbal treatments to control diabetes, and this use is predicated on the idea that specific plants and plant extracts contain antidiabetic qualities. Garlic, neem, coriander, ivy gourd, papaya, jamun, tulsi, aloe vera, and many other plants are used in herbal therapies for diabetes. Since free radical damage is believed to have a part in the etiology of diabetes and its associated issues, an anti-diabetic drug having antioxidant qualities would be more successful. In conclusion, herbal remedies have shown promising anti-diabetic benefits and might be thought of as alternatives to or complements to current diabetes management strategies. To assess their efficacy, safety, and the best approach to use them in the management of diabetes, more research is needed. Before beginning therapy, it is crucial to consider the use of herbal products as diabetic therapies with a qualified medical expert due to the risk of interactions with other medications and the fact that every person’s health is different. To ensure its trustworthiness in terms of both efficacy and safety, herbal products must be subjected to standardization and quality control.

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Published

2023-06-13

How to Cite

Sen, D. B., Balaraman, R., Sen, A. K., Zanwar, A. S., Greeshma, K. P., & Maheshwari, R. A. (2023). Anti-Diabetic Activity of Herbal Remedies. Journal of Natural Remedies, 23(2), 373–381. https://doi.org/10.18311/jnr/2023/32182

Issue

Volume 23, Issue 2, April 2023

Section

Short Review

License

Copyright (c) 2023 Dhanya B. Sen, Ramachandran Balaraman, Ashim Kumar Sen, Aarti S. Zanwar, K. P. Greeshma, Rajesh A. Maheshwari (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

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Received 2022-12-15
Accepted 2023-04-21
Published 2023-06-13

 

References

Kumar A, Goel MK, Jain RB, Khanna P, Chaudhary V. India towards diabetes control: Key issues. Australas Med J. 2013; 6(10):524-31. https://doi.org/10.21767/AMJ.2013.1791 DOI: https://doi.org/10.4066/AMJ.2013.1791

Rahimi M. A Review: Anti Diabetic medicinal plants used for diabetes mellitus. Bull Env Pharmacol Life Sci. 2015; 4:163–80.

Matteucci, E, Giampietro O. Oxidative stress in families of Type 1 diabetic patients. Diabetes Care. 2000; 23:1182-6. https://doi.org/10.2337/diacare.23.8.1182 DOI: https://doi.org/10.2337/diacare.23.8.1182

Oberlay LW. Free radicals and diabetes. Free Radic Biol Med. 1988; 5:113-24. https://doi.org/10.1016/0891-5849(88)90036-6 DOI: https://doi.org/10.1016/0891-5849(88)90036-6

Baynes JW, Thorpe SR. The role of oxidative stress in diabetic complications. Curr Opin Endocrinol. 1997; 3:277-84. https://doi.org/10.1097/00060793-199608000-00001 DOI: https://doi.org/10.1097/00060793-199608000-00001

Lipinski B. Pathophysiology of oxidative stress in diabetes mellitus. J Diabet Complications. 2001; 15:203-10. https://doi.org/10.1016/S1056-8727(01)00143-X DOI: https://doi.org/10.1016/S1056-8727(01)00143-X

Kubish HM, Vang J, Bray TM, Phillips JP. Targeted over expression of Cu/Zn superoxide dismutase protects pancreatic beta cells against oxidative stress. Diabetes. 1997; 46:1563-66. https://doi.org/10.2337/diacare.46.10.1563 DOI: https://doi.org/10.2337/diabetes.46.10.1563

Naziroglu M, Cay M. Protective role of intraperitoneally administered vitamin E and selenium on the oxidative defense mechanisms in rats with diabetes induced by streptozotocin. Biol Stress Elem Res. 2001; 47:475–88.

Available from: https://timesofindia.indiatimes.com/india/why-india-is-diabetes-capital-of-the-world/articleshow/95509990.cms

Ozkum D. Akı O, Toklu HZ. Herbal medicine use among diabetes mellitus patients in Northern Cyprus. J Med Plant Res. 2013; 7:1652-64.

Narayan DS, Patra VJ, Dinda SC. Diabetes and Indian traditional medicines an overview. Int J Pharm Pharm Sci. 2012; 4(3):45-53.

Recent TP. Trends in therapeutic approaches for diabetes management: A comprehensive update. J Diabetes Res. 2015. https://doi.org/10.1155/2015/340838 DOI: https://doi.org/10.1155/2015/340838

Kumari MS, Lakshmi KN, Prasanna TVVNL, Swapna K, Jyothi AS, et al. Natural herbs vs allopathic drugs: To treat diabetes. Indo Am J Pharm Sci. 2016; (3):415-22.

Dey L, Anoja SA, Yuan CS. Alternative therapies for Type 2 diabetes. Alternative Med Rev. 2002; 7:45-58. https://doi.org/10.1211/fact.2002.00120 DOI: https://doi.org/10.1211/fact.2002.00120

Modak M, Dixit P, Londhe J, Ghaskadbi S, Devasagayam TP. Indian herbs and herbal drugs used for the treatment of diabetes. J Clin Biochem Nutr. 2007; 40(3):163-73. https://doi.org/10.3164/jcbn.40.163 DOI: https://doi.org/10.3164/jcbn.40.163

Gupta R, Bajpai KG, Johri S, Saxena AM. An overview of Indian novel traditional medicinal plants with anti-diabetic potentials. Afr J Tradit Complement Altern Med. 2008; 5(1):1-17.

Malvi R, Jain S, Khatri S, Patel A, Mishra S. A review on antidiabetic medicinal plants and marketed herbal formulations. Int J Pharm Biol Sci Arch. 2011; 2:1344-55.

Gebreyohannes G, Gebreyohannes M. Medicinal values of garlic: A review. Int J Med Med Sci. 2013; 5:401-8.

Lakshmi MS. Rani KSS, Reddy UKT. A review on diabetes mellitus and the herbal plants used for its treatment. Asian J Pharm Clin Res. 2012; 5:15–21.

Al-Awadi, FM, Gumaa KA. Studies on the activity of individual plants of an antidiabetic plant mixture. Acta Diabetologica. 1987; 24:37-41. https://doi.org/10.1007/BF02732051 DOI: https://doi.org/10.1007/BF02732051

Ajabnoor MA. Effect of aloes on blood glucose levels in normal and alloxan diabetic mice. J Ethnopharmacol. 1990; 28:215-20. https://doi.org/10.1016/0378-8741(90)90031-N DOI: https://doi.org/10.1016/0378-8741(90)90031-N

Davis RH, Maro NP. Aloe vera and gibberellin. Anti-inflammatory activity in diabetes. J Am Pediat Med Assoc. 1989; 79(1):24-6. https://doi.org/10.7547/87507315-79-1-24 DOI: https://doi.org/10.7547/87507315-79-1-24

Manjunath K, Subash KR, Tadvi NA, Manikanta M, Rao U. Effect of Aloe vera leaf extract on blood glucose levels in alloxan induced diabetic rats. Natl J Physiol Pharm Pharmacol. 1970; 6(5):471-4. https://doi.org/10.5455/njppp.2016.6.0718613072016 DOI: https://doi.org/10.5455/njppp.2016.6.0718613072016

Bordoloi R, Dutta KN. A review on herbs used in the treatment of Diabetes mellitus. J Pharm Chem Biol Sci. 2014; 2:86-92.

Wadood A, Wadood N, Shah SA. Effects of Acacia arabica and Caralluma edulis on blood glucose levels on normal and alloxan diabetic rabbits. J Pakistan Med Assoc. 1989; 39:208-12.

Chattopadhyay RR. Chattopadhyay RN, Nandy AK, Poddar G, Maitra SK. The effect of fresh leaves of Azadiracta indica on glucose uptake and glycogen content in the isolated rat hemidiaphragm. Bull Calcutta Sch Trop Med. 198; 35:8-12.

Biswas K, Chattopadhyay I, Banerjee RK, Bandyopadhyay U. Biological activities and medicinal properties of neem (Azadiracta indica). Curr Sci. 2002; 82:1336-45.

Rasineni K, Bellamkonda R, Singareddy SR, Desireddy S. Antihyperglycemic activity of Catharanthus roseus leaf powder in streptozotocin-induced diabetic rats. Pharmacognosy Res. 2010; 2(3):195-201. https://doi.org/10.4103/0974-8490.65523 DOI: https://doi.org/10.4103/0974-8490.65523

Das S, Chaware S, Narkar N, Tilak AV, Raveendran S, Rane P. Antidiabetic activity of Coriandrum sativum in streptozotocin induced diabetic rats. Int J Basic Clin Pharmacol. 2019; 8(5):925-9. https://doi.org/10.18203/2319-2003.ijbcp20191577 DOI: https://doi.org/10.18203/2319-2003.ijbcp20191577

Kamble SM, Kamlakar PL, Vaidya S, Bambole V.D. Influence of Coccinia indica on certain enzymes in glycolytic and lipolytic pathway in human diabetes. Indian J Med Sci. 1998; 52:143-6.

Giovannini P, Howes MJ, Edwards SE. Medicinal plants used in the traditional management of diabetes and its sequelae in Central America: A review. J Ethnopharmacol. 2016; 184:58-71. https://doi.org/10.1016/j.jep.2016.02.034 DOI: https://doi.org/10.1016/j.jep.2016.02.034

Achrekar S, Kaklij GS, Pote MS, Kelkar SM. Hypoglycemic activity of Eugenia jambolana and Ficus bengalensis: Mechanism of action. In vivo (Athens, Greece). 1991; 5(2):143-7.

Khanna P, Jain SC, Panagariya A, Dixit VP. Hypo- glycemic activity of polypeptide-p from a plant source. J Nat Prod. 1981; 44:648-55. https://doi.org/10.1021/np50018a002 DOI: https://doi.org/10.1021/np50018a002

Shibib BA, Khan LA, Rahman R. Hypoglycemic activity of Coccinia indica and Momordica charantia in diabetic rats: Depression of the hepatic gluconeo-genic enzymes glucose-6-phosphatase and fructose-1, 6-biphosphatase and elevation of liver and red-cell shunt enzyme glucose-6-phosphate dehydrogenase. Biochem J. 1993; 292:267-70. https://doi.org/10.1042/bj2920267 DOI: https://doi.org/10.1042/bj2920267

Aderibigbe AO, Emudianughe TS, Lawal BA. Antihyperglycemic effect of Mangifera indica in rat. Phytother Res. 1999; 13:504-07. https://doi.org/10.1002/(SICI)1099-1573(199909)13:6<504::AID-PTR533>3.0.CO;2-9 DOI: https://doi.org/10.1002/(SICI)1099-1573(199909)13:6<504::AID-PTR533>3.0.CO;2-9

Vats V, Grover JK, Rathi SS. Evaluation of anti- hyperglycemic and hypoglycemic effect of Trigonella foenum graecum Linn, Ocimum sanctum Linn and Pterocarpus marsupium Linn in normal and alloxanized diabetic rats. J Ethnopharmacol. 2002; 79: 95-100. https://doi.org/10.1016/S0378-8741(01)00374-9 DOI: https://doi.org/10.1016/S0378-8741(01)00374-9

Rai V, Iyer, U, Mani UV. Effect of Tulasi (Ocimum sanctum) leaf powder supplementation on blood sugar levels, serum lipids and tissue lipid in diabetic rats. Plant Foods Hum Nutr. 1997; 50:9-16. https://doi.org/10.1007/BF02436038 DOI: https://doi.org/10.1007/BF02436038

Vats V, Yadav SP. Grover, Ethanolic extract of Ocimum sanctum leaves partially attenuates streptozotocin induced alteration in glycogen content and carbohydrate metabolism in rats. J Ethnopharmacol. 2001; 90:155-60. https://doi.org/10.1016/j.jep.2003.09.034 DOI: https://doi.org/10.1016/j.jep.2003.09.034

Jahromi MA, Ray AB, Chansouria JPN. Anti- hyperlipidemic effect of flavonoids from Pterocarpus marsupium. J Nat Prod. 1993; 56:989-94. https://doi.org/10.1021/np50097a001 DOI: https://doi.org/10.1021/np50097a001

Ahmad F, Khalid P, Khan MM, Rastogi AK, Kidwai JR. Insulin like activity in (−) epicatechin. Acta Diabetol Lat. 1989; 26:291-300. https://doi.org/10.1007/BF02624640 DOI: https://doi.org/10.1007/BF02624640

Sangeetha MK, Priya CM, Vasanthi HR. Anti-diabetic property of Tinospora cordifolia and its active compound is mediated through the expression of Glut-4 in L6 myotubes. Phytomedicine. 2013; 20(3-4):246-8. https://doi.org/10.1016/j.phymed.2012.11.006 DOI: https://doi.org/10.1016/j.phymed.2012.11.006

Sauvaire Y, Petit P, Broca C, Manteghetti M, Baissac Y, Fernandez-Alvarez J, et al. 4-hydroxyisoleucine: A novel amino acid potentiator of insulin secretion. Diabetes. 1998; 47:206-10. https://doi.org/10.2337/diab.47.2.206 DOI: https://doi.org/10.2337/diabetes.47.2.206

Khosla P, Gupta DD, Nagpal RK. Effect of Trigonella foenum graecum (fenugreek) on blood glucose in normal and diabetic rats. Indian J Physiol Pharmacol. 1995; 39:173-4.

Gupta D, Raju J, Baquer NZ. Modulation of some gluconeogenic enzyme activities in diabetic rat liver and kidney: Effect of antidiabetic compounds. Indian J Expt Biol. 1999; 137:196-9.

Elavarasi S, Saravanan K, Renuka C. A systematic review on medicinal plants used to treat diabetes mellitus. Int J Pharma Chem Biol Sci. 2013; 3:983-92.

World Health Organization. Traditional medicine: Report by the secretariat. 2002. Available from: https://apps.who.int/iris/bitstream/handle/10665/68358/a75606.pdf. https://doi.org/10.1186/s13020-016-0108-7

Chen SL, Yu H, Luo HM, WuQ, Li CF, Steinmetz, A. Conservation and sustainable use of medicinal plants: Problems, progress, and prospects. Chin Med. 2016; 11;1-10. DOI: https://doi.org/10.1186/s13020-016-0108-7

Rosalie IO, EL E. Antidiabetic potentials of common herbal plants and plant products: A glance. Int J Herb Med. 2016; 4:90-7.

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