Toxicology International

A Study on the Toxic Effects of Doxorubicin on the Histology of Certain Organs


Affiliations

  • College of Veterinary Science, Departments of Pharmacology and Toxicology, Hyderabad, Andhra Pradesh, India
  • College of Veterinary Science, Pathology, Hyderabad, Andhra Pradesh, India

Abstract

In the present study, effect of doxorubicin at 2 mg/kg b.wt. (i/p), alone, once in a wk for 4 wks and in combination with vitamin E at 250 and 500 mg/kg b.wt., orally, daily for 4 wks was evaluated on histological alterations, if any, on heart, liver, kidney, and testes of rats. Doxorubicin alone treated group showed marked congestion and degenerative changes in heart, kidney, liver, and testis. Treatment with vitamin E showed marked improvement in all the degenerative changes, though more protection was observed with the dose of 500 mg/kg.

Keywords

Doxorubicin, histopathology, vitamin-E Original Article on

Full Text:

References

Abullaev FI, Luna RR, Roitenburd BV, Espinosa AJ. Pattern of childhood cancer mortality in Mexico. Arch Med Res 2000;31:526-31.

Arcamone F, Cassinelli G, Fantini G. Adriamycin, 14hydroxydaunomycin, A new antitumor antibiotic from S.peucetius var. caesius. Biotechnol Bioeng 1969;11:1101-10.

Gianni L, Salvatorelli E, Minotti G. Anthracycline cardiotoxicity in breast cancer patients: Synergism with trastuzumab and taxanes. Cardiovasc Toxicol 2007;7:67-71.

Naiyara A, Abdul E, Ali AA, Ahmed RA. Simavastatin cardioprotective effect in doxorubicin induced cardiotoxicity in rats. J Basic Appl Sci 2010;6:29-38.

Bertani T, Poggi A, Pozzoni R, Delani F, Sacchi G, Thoua Y, et al.Adriamycin–induced nephritic syndrome in rats. Lab Invest 1982;46:16-23.

Kalender Y, Yel M, Kalender S. Doxorubicin hepatotoxicity and hepatic free radical metabolism in rats. Toxicology 2005;209: 39-45.

Patil RL, Balaraman R. Effect of melatonin on doxorubicin induced testicular damage in rats. Int J Pharma Tech Res 2009;1:879-84.

De Beer EL, Bottone AE, Voest EE. Doxorubicin and mechanical performance of cardiac trabeculae after acute and chronic treatment: A review. Eur J Pharmacol 2001;415:1-11.

Traber T, Atkinson J. Alpha tocopherol is a scavenger of peroxynitrile radicals. Free Radical Biol Med 2007;43:4-15.


Refbacks

  • There are currently no refbacks.